NS1 Protein
NS1-Binding Protein (NS1-BP): a Novel Human Protein That Interacts with the Influenza A Virus Nonstructural NS1 Protein Is Relocalized in the Nuclei of Infected Cells
... ICP27 protein (46, ...the NS1 protein is localized throughout the nucleus in a diffuse ...of NS1-BP in pre-mRNA splicing and the role of the NS1– NS1-BP interaction in ...
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Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein
... influenza NS1 protein in RBM14 nucleolar ...IAV protein was responsible for RBM14 relocalization, individual influenza A/PR/8/34 (H1N1) virus Flag-tagged protein expression plasmids were trans- ...
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Attenuation of Equine Influenza Viruses through Truncations of the NS1 Protein
... the NS1 gene (delNS1) could only replicate in interferon (IFN)-incompetent systems, suggesting that the NS1 protein is responsible for IFN antagonist ...the NS1 protein did not ...
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Multiple Anti-Interferon Actions of the Influenza A Virus NS1 Protein
... viral NS1 gene product of FLUAV mediates resistance to the IFN system so that the virus is able to replicate even in the presence of a functional IFN ...of NS1 proteins of various FLUAV strains to confer an ...
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Influenza C virus NS1 protein counteracts RIG I mediated IFN signalling
... virus NS1 protein has IFN antagonistic prop- erties like the respective proteins from influenza A and B ...the NS1 regions involved in inhibi- tion of the IFN-b promoter showed that proteins devoid ...
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Interaction of influenza virus NS1 protein with growth arrest specific protein 8
... NS1 protein is the only non-structural protein encoded by the influenza A virus, and it contributes significantly to disease pathogenesis by modulating many virus and host cell ...with NS1 ...
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NS1 Protein of Influenza A Virus Down-Regulates Apoptosis
... designated NS1. NS1 is expressed together with the nucleocapsid protein NP soon after virus entry into the cell and acts at an early stage of infection (for a review, see reference ...addition, ...
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The NS1 Protein of Influenza A Virus Interacts with Cellular Processing Bodies and Stress Granules through RNA-Associated Protein 55 (RAP55) during Virus Infection
... between NS1 and the cel- lular factor RAP55 and further characterized the relationship be- tween NS1 and the formation of RAP55-associated stress granules and P-bodies during influenza virus ...binding ...
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Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein
... of NS1 to bind CPSF30 is a human-adaptive phenotype that is selected against in ...Cal/09 NS1 protein negatively affect another of the multiple NS1 functions independently of their clear ...
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Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells
... the NS1 RNA-binding domain induces ...the NS1 protein is required for NS-induced apoptosis in MDCK ...whose NS1 proteins have mutations that abolish RNA-binding/dimerization ...for ...
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Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA.
... To determine whether the NS1 loss-of-function mutants in the second domain exhibited a dominant negative phenotype, increasing amounts of a plasmid expressing the NS1 protein with an L-t[r] ...
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The NS1 protein of influenza a virus interacts with heat shock protein Hsp90 in human alveolar basal epithelial cells: Implication for virus induced apoptosis
... the NS1 and hsp90 by using a mammalian two-hybrid system. The NS1 (H5N1 or H3N2) and Hsp90 genes were cloned into the pBIND and pACT vectors to generate fusion proteins with the GAL4 DNA-binding domain ...
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Influenza Virus Evades Innate and Adaptive Immunity via the NS1 Protein
... the NS1 protein was shown to be a potent IFN antagonist in epithelial cells through its N-terminal double-stranded RNA- binding domain, which prevents the induction of type I IFN synthesis during viral ...
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Influenza C Virus NS1 Protein Upregulates the Splicing of Viral mRNAs
... the NS1 protein of the influenza A virus PR/8/34 strain demonstrated that the splicing rate of influenza C virus NS mRNA ...virus NS1 protein on mRNA splicing, which has been reported (6, 7, ...
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Cloning and overexpression of influenza a H1N1 NS1 protein in escherichia coli
... The NS1 recombinant protein of influenza A H1N1 was successfully cloned into pET-32c(+) vector and this led to subsequent expression of the recombinant protein in ...of protein separation and ...
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The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication
... Individual NS1 protein expression and PARP10 knock- down did not have significant effect on cell cycle in A549 cells, but the NS1 protein expression and PARP10 knock-down together would ...
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Influenza A Virus NS1 Protein Activates the PI3K/Akt Pathway To Mediate Antiapoptotic Signaling Responses
... viral NS1 protein (delNS1) failed to activate the PI3K/Akt pathway ...binding NS1 protein, recent analyses have shown that a major in vivo function is to antagonize the antiviral type I ...
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Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA
... adaptor protein to interact with Aly and thus recruit the TREX complex components needed for export ...IAV NS1 protein has been hypothesized to perform an analogous function, based on its known ...
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The multifunctional NS1 protein of influenza A viruses
... the NS1 proteins of avian, but not human, influenza viruses hyperactivate PI3K by binding the N-terminal SH3 domains of Crk and/or CrkL, two highly related human signalling proteins (Heikkinen et ...in NS1 ...
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Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection
... significant NS1 expression differ- ences were seen by ELISA, but not by PCR, we assume that the observed effect occurs at the level of translation, not ...decreased NS1 protein expression in plasmid ...
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