NSCLC cells
<p>miRNA-101-5p inhibits the growth and aggressiveness of NSCLC cells through targeting CXCL6</p>
... in NSCLC. The levels of miR-101-5p in 55 pairs of NSCLC tissues and corre- sponding normal tissues were evaluated using qRT-PCR ...in NSCLC when compared with the corresponding normal lung samples ...
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Sulforaphane attenuates EGFR signaling in NSCLC cells
... TKI-resistant NSCLC cells harboring mutant EGFR (H1975 and PC9/gef ) than wild-type EGFR (A549) ...PC9/gef cells with sulforaphane (0 – 20 μM) and exam- ined EGFR-related ...PC9/gef cells, and ...
9
Specific inhibitor of Notch‑3 enhances the sensitivity of NSCLC cells to gemcitabine
... that cells with long-term exposure to GEM have enhanced expression of Notch-3 and increased resistance to ...A549 cells were exposed to GEM to induce overexpression of Notch-3 and to avoid the ...
10
USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells
... EGFRMT NSCLC cells upon USP17 depletion ...EGFR-dependent NSCLC cell lines has previously been shown to induce apoptosis [29], we hypothesized that the observed reduction in Src activa- tion ...H1975 ...
12
Non-small-cell lung carcinoma: role of the Notch signaling pathway
... of cells that express both Notch receptors and ligands, can still bind Notch receptors but this association prevents ...endothelial cells, through aug- mented expression of Delta-4, prevent the ...
11
SOSTDC1 is down-regulated in non-small cell lung cancer and contributes to cancer cell proliferation
... in NSCLC implicates that SOSTDC1 is likely to be bio- logically involved in the development and progression of the ...of NSCLC cells, and that such an anti-prolifer- ative function is associated with ...
10
Original Article The role of Axl in drug resistance and epithelial-to-mesenchymal transition of non-small cell lung carcinoma
... in NSCLC cell sur- vival, we chose two NSCLC cells for our research: the EGFR wild type A549 cell and H460 ...H460 cells with high endogenous Axl expression to stably or transiently ...
9
Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade
... that NSCLC cells carrying an oncogenic KRAS mutation exhibit primary resistance to anti-EGFR therapy with small molecule inhibitors such as erlotinib, and propose that these KRAS-addicted cells ...
13
Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer with T790M mutations
... including NSCLC, regulates many cell cycle events, including mitotic entry, centrosome maturation, kinetochore assembly, and bipolar spindle ...in NSCLC with acquired EGFR TKI resistance has been ...
13
Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
... Other studies have reported that simvastatin augmented apoptosis in NSCLC cells [12, 14, 24]. Pyroptosis can be distinguished from apoptosis by three characteristics. First, pyroptosis is accompanied by ...
12
<p>Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway</p>
... dissociative anti-apoptotic protein Bcl-2 and blocks the activation of pro-apoptotic proteins caspase-9 and caspase-3. 23,24 The activation of PI3K/AKT/mTOR path- way can also promote cell proliferation. For example, AKT ...
8
Original Article MicroRNA-630 acts as a prognostic marker in gastric cancer and its role in cell migration and invasion
... arrest cells in G0-G1 phase and reduce proliferation rates in non- small cell lung cancer cells ...A549 cells [23]. Similarly, Song et al. assessed 22 patients with NSCLC and found that ...
10
Original Article B7-H3 in combination with regulatory T cell is associated with tumor progression in primary human non-small cell lung cancer
... In summary, this study showed that expression of B7-H3 in NSCLC cells and tumor-infiltrating FOXP3+ Tregs predict worsened prognosis. A significant correlation between B7-H3 and FOXP3+ Tregs was detected ...
9
Original Article MicroRNA-146 inhibits epithelial-mesenchymal transition by regulating FOXM1 in lung cancer cells
... in NSCLC cells, we next detected the effects of ectopic transfection of miR-146 on express- ions of two important EMT molecular markers E-cadherin and vimentin in H1299 cell ...H1299 cells raised ...
8
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion
... in NSCLC cells, the expression level of ALDH1L1 in lung cancer cell lines was measured by liquid chromatography multiple reaction monitoring mass spectrometry (MRM-MS) (Figure ...in NSCLC were higher ...
14
Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44
... in NSCLC cells, which revealed high levels of ΔCS-0S, ΔCS-4S, ΔCS-6S, ΔHS-0S and ΔHS-NS disaccharides related to SRGN expressed by both H1299/SRGN and H460/sh- CTRL ...from NSCLC cells was ...
18
<p>LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1</p>
... in NSCLC tissues in the downloaded pro fi les from GEO database were analyzed and further veri fi ed in 100 pairs of NSCLC samples collected in our ...of NSCLC patients was ...of NSCLC ...
12
Original Article Adenanthin induces G2/M arrest and apoptosis in human non-small-cell lung cancer cells
... healthy cells and tumor cells (Figure ...carcinoma cells at IC50 values ranging between 20 μmol/L to 200 μmol/L. NSCLC cells were noted to be exqui- sitely vulnerable to the deleterious ...
11
Original Article MiR-199b-5p suppresses proliferation and invasion of non-small cell lung cancer (NSCLC) via HER2/PI3K/ Akt pathway
... in NSCLC and to explore its molecular mechanism in NSCLC ...human NSCLC specimens compared to that in NC ...H460 cells inhibited NSCLC proliferation and ...in NSCLC cells. ...
7
<p>Long Non-Coding RNA SPRY4-IT1 Reverses Cisplatin Resistance by Downregulating MPZL-1 via Suppressing EMT in NSCLC</p>
... of NSCLC, and promotes cell proliferation and metastasis by affecting the epithelial – mesenchymal transition ...in NSCLC remains ...of NSCLC cells to cisplatin both in vitro and in ...
11