Nuclear accumulation
DDB2 Induces Nuclear Accumulation of the Hepatitis B Virus X Protein Independently of Binding to DDB1
... located between residues 238 and 278. Extracts of the trans- fected cells were subjected to immunoprecipitation with a monoclonal antibody against T7 that was covalently linked to Sepharose beads. Immunoprecipitates were ...
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Nuclear accumulation of polyglutamine disease proteins and neuropathology
... the nuclear accumulation and aggregation of the disease ...Neuronal nuclear inclusions are considered to be a histopathological hallmark of the polyQ diseases and are even observed in disease brains ...
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Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation
... of nuclear localization signal (NLS) receptors, karyopherin ␣ 1 (importin ␣ 5) (45, 48, ...the nuclear accumulation of these STAT1-containing complexes (45, 48, ...and nuclear accumula- tion ...
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Predicting Adjuvant Chemotherapy Outcome by Simultaneous Analysis of Thymidylate Synthase Expression and p53 Nuclear Accumulation in Colorectal Cancer
... IHC stainings were assessed using anti-p53 and anti-TS antibodies (Figure 1(C)). In the entire cohort of 299 pa- tients (treated and untreated), 175 (58.5%) showed high TS expression (TS+) and 138 (46.2%) showed high p53 ...
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The N-Terminal Extension of the Influenza B Virus Nucleoprotein Is Not Required for Nuclear Accumulation or the Expression and Replication of a Model RNA
... that nuclear accumulation of the protein is ...the nuclear localization signal is not located at the extreme N terminus, as in influenza A virus ...
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Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP dependent nuclear accumulation of zyxin and Akt
... Nuclear accumulation of zyxin as a mediator of antiapoptotic signaling is an attractive candidate for participation in promotion of Akt activity based upon prior observations linking nuclear accu- ...
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Nuclear Accumulation of the GATA Factor AreA in Response to Complete Nitrogen Starvation by Regulation of Nuclear Export
... AreA nuclear export occurs via the CrmA exportin. The slow nuclear accumulation and rapid loss of AreA suggests that nuclear export is the major control of AreA nuclear accumu- ...for ...
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Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation
... predicted nuclear localization sequence (NLS) (Xiao et ...influencing nuclear localization of ...constitutively nuclear localization when they mutated the Erk phosphorylation sites in ...the ...
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CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer
... CAIPIN1 nuclear expression displayed shorter postoperative survival times than those with weak nuclear ...that nuclear ex- pression of CIAPIN1 is closely related to the poor prognosis of patients ...
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Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus
... slight accumulation of Smad2 homodimers in the nucleus of responding cells (b) and dramatic accumulation of Smad2-Smad4 heterodimers ...of nuclear BiFC fluorescence by late gastrula stage ...Strong ...
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Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage
... of nuclear DNA leakage activates nucleophagy Since doxorubicin (DOX) is known to cause DNA dam- age, we first examined the effects of doxorubicin on phos- phorylation of H2AX (Ser139), a key DNA damage signal, in ...
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Defective nuclear accumulation of androgen receptors in disorders of sexual differentiation
... Nuclear transfer of androgen receptors (AR) and glucocorticoid receptors (GR) was determined in cultured genital skin fibroblasts from 10 normal controls and eight patients with abnormalities of the external ...
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Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2
... across the limiting membrane, and nuclear accumulation of the L2/vDNA complex 255.. requires mitosis and is summarized in greater detail in latter sections of this review. For 256.. th[r] ...
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Interaction of the Influenza Virus Nucleoprotein with the Cellular CRM1-Mediated Nuclear Export Pathway
... creased nuclear accumulation after LMB ...increased nuclear accumula- tion of the polypeptide after CRM1 inhibition, no change in its distribution was observed ...the nuclear matrix (4, 22) ...
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Recent Advances in Nitrogen Regulation: a Comparison between Saccharomyces cerevisiae and Filamentous Fungi
... the nuclear localization of Gln3 in response to rapamycin treatment and growth on poor nitrogen sources may be controlled by different mechanisms inducing short- and long-term responses, respec- ...of ...
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X-Box Binding Protein 1 Contributes to Induction of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle under Hypoxic Conditions
... and nuclear HIF-1 ␣ , both of which can be rapidly activated by relevant stresses leading to lytic replication (6, ...why nuclear accumulation of HIF-1 ␣ fails to induce the KSHV lytic cycle in ...
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Role of nuclear pore complex in simian virus 40 nuclear targeting.
... The nuclear accumulation of virion protein components and large T antigen in nonpermissive NIH 3T3 cells was similar to that in the permissive host, indicating that the ability to use NP[r] ...
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Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation.
... We have examined the nuclear transport of the protein products of our v-myb deletion and truncation mutants and identified two indepen dent in nuclear accumulation of p48vmyb Mutants and[r] ...
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The Selective Inhibitor of Nuclear Export Compound, Selinexor, Inhibits NF-κb and Induces Anti-Non-Small Cell Lung Cancer Activity Regardless of p53 Status
... increase nuclear localization of NF-κB and IκB as well as inhibit NF-κB activity in many different types of cancers ...induced nuclear retention of NF-κB/IκB complexes and inhibited NF-κB activity which was ...
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Differential stability of β catenin along the animal vegetal axis of the sea urchin embryo mediated by dishevelled
... regulated nuclear import and/or export, possibly involving interactions with cytoplasmic or nuclear anchoring proteins (Henderson and Fagotto, 2002; Tolwinski et ...for nuclear import or ...regulate ...
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