Nuclear export
Regulation of Stat3 nuclear export
... induces nuclear accumulation of endogenous ...(St3) nuclear export, two distinct cell types and signaling pathways were exam- ined: IL-6 stimulation in HepG2 cells and IFN- α stim- ulation in HEK293 ...
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Influenza polymerase encoding mRNAs utilize atypical mRNA nuclear export
... in nuclear trafficking is an assembly of nucleoporins located within the nuclear envelope termed the Nuclear Pore Complex ...require nuclear export signals to export through the ...
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Ltv1 Is Required for Efficient Nuclear Export of the Ribosomal Small Subunit in Saccharomyces cerevisiae
... subunit export (M oy and S ilver ...that export of the small subunit, unlike that of the large subunit, may involve multiple adapter proteins whose export functions are partially redun- ...a ...
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Protection from Disulfide Stress by Inhibition of Pap1 Nuclear Export in Schizosaccharomyces pombe
... the nuclear export signal of Oxs1, a conserved eukaryotic protein that, along with Pap1, regulates certain diamide responsive genes, can retain Pap1 in the nucleus before stress by competing for ...
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Identification and Characterization of Three Novel Nuclear Export Signals in the Influenza A Virus Nucleoprotein
... possess nuclear export ...If nuclear export occurs (if an NES exists), the shuttling protein would be able to enter the cyto- plasm of heterokaryon and be imported into the NIH 3T3 recip- ient ...
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Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus
... acquire nuclear export ...with export capacity and was cell type ...the nuclear import and export potential required to complete the infectious cycle of the karyophilic ...
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Influenza Virus-Induced Caspase-Dependent Enlargement of Nuclear Pores Promotes Nuclear Export of Viral Ribonucleoprotein Complexes
... the nuclear membrane to (i) import primary RNPs into the nucleus and (ii) export newly produced RNPs across the nuclear membrane to the cell membrane, where viral assembly takes place (2, ...the ...
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Exportin 1 Mediates Nuclear Export of the Kinetoplastid Spliced Leader RNA
... tarentolae nuclear extract is in the 3⬘-extended form, implying the lack of 3⬘-processing activity in the nucleus; these transcripts also lack cap 4 methylations ...the nuclear export machinery ...
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Polyuridylated mRNA Synthesized by a Recombinant Influenza Virus Is Defective in Nuclear Export
... Recently, by replacing the U track with an A track at the polyadenylation site of model vRNA templates, we demon- strated that the influenza virus polymerase was able to synthe- size polyuridylated mRNA in vitro and in ...
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Role of the Influenza Virus M1 Protein in Nuclear Export of Viral Ribonucleoproteins
... vRNP export, NS2 may play a role in nuclear export of the late viral ...the export of the unspliced M1 message in a manner analogous to that of HIV type 1 Rev, which is needed for ...
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Characteristics of Nucleocytoplasmic Transport of H1N1 Influenza A Virus Nuclear Export Protein
... NEP nuclear import ...the nuclear export process of influenza vRNPs, the nuclear import mecha- nism of NEP remains ...of nuclear localization signals (NLSs), suggesting that their ...
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Ubiquitination of HTLV I Tax in response to DNA damage regulates nuclear complex formation and nuclear export
... within nuclear foci that con- tain sc35, a splicing factor that was previously shown to be a component of TSS ...CRM1 nuclear export pathway resulted in an accumulation of UB-Tax in nuclear ...
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Characterization of the Nuclear Export Signal in the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein
... In many cases, the structural context of these leucine resi- dues is important, especially in binding to the partner protein complexes involved in export, and two defined characteristics of an active NES are ...
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Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1
... The hydrophobic residues in the NES are important for nuclear export of VP19C, and VP19C is exported from the nucleus through the NES via a CRM1-dependent pathway. However, CRM1-mediated transport is highly ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... an export sub- strate of CRM1 and identifies in HIV ...CRM1-mediated nuclear export has been reported to be involved in several viral infections, including the influenza A virus [40, 41], human ...
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Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase
... Figure 4-3. The carboxy-terminal tail of AMPKα functions as a nuclear export sequence (NES). (A) Schematic representation of the four constructs containing two tandem GFP molecules (2xGFP) with or without ...
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The Nuclear Export Receptors TbMex67 and TbMtr2 Are Required for Ribosome Biogenesis in Trypanosoma brucei
... TbMtr2 and TbMex67 are essential proteins in T. brucei. Previous studies in T. brucei have demonstrated that the depletion of the nuclear export proteins TbMtr2 and TbMex67 results in significant growth ...
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Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agents
... The nuclear export of proteins depends on the activity of transport proteins, ...sole nuclear exporter of several tumor suppressor (TSP), growth regulatory (GRP) ...the export of these pro- ...
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The Nuclear Export and Ubiquitin-Proteasome-Dependent Degradation of PPARγ Induced By Angiotensin II
... PPARγ nuclear export was prevented by pre-incubation with different concentrations of Tro (10 and 20 ...PPARγ nuclear translocation could be partially inhibited by further increasing the ...
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Presence of a functional but dispensable Nuclear Export Signal in the HTLV 2 Tax protein
... the nuclear envelope [20,21]. The nuclear envelope contains nuclear pore complexes (NPCs), which mediate the traffic of molecules between the two ...specific nuclear import and export ...
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