nuclear export signal sequence
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein
... Previous studies identified two P-binding regions in the N sequence (Fig. 1a) and demonstrated that higher expression of P inhibits nuclear export of N by masking the NES, leading to the regulation ...
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Presence of a functional but dispensable Nuclear Export Signal in the HTLV 2 Tax protein
... GFP sequence (NES2-EGFP) using the pEGFP-N1 vector as previously reported ...Tax1 sequence was also fused to the N-terminus of the GFP ...NES sequence, the GFP protein is nearly equally distributed ...
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Detailed Mapping of the Nuclear Export Signal in the Rous Sarcoma Virus Gag Protein
... a nuclear import signal within the MA ...prevent nuclear ex- port, leading to the accumulation of Gag in the nucleus, sug- gesting that the presence of an intact p10 domain is necessary for ...
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Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase
... Defined Nuclear Export ...on sequence alignment with other previously characterized CRM1-dependent NESs (Figure 4-3C) and confirmed the functional consequences of truncating only the final 14 amino ...
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Nuclear Export Signal-Interacting Protein Forms Complexes with Lamin A/C-Nups To Mediate the CRM1-Independent Nuclear Export of Large Hepatitis Delta Antigen
... acid sequence analysis revealed the existence of putative N-glycosylation sites and transmembrane helices in the NESI ...potential signal pep- tide has been predicted for NESI, these results indicate that ...
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A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for Efficient Virus Replication
... the sequence encoding the Flu-A-M1 NES was artificially synthesized, and the WT and mutant M1 coding sequences were amplified by PCR and inserted be- tween the BamHI and XhoI sites in the pEGFP-C1 vector, ...The ...
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A Second CRM1-Dependent Nuclear Export Signal in the Influenza A Virus NS2 Protein Contributes to the Nuclear Export of Viral Ribonucleoproteins
... acid sequence positions 22 to 45 of the influenza A virus NEP can mediate the nuclear export of two tandem ...consensus sequence, “X” represents any amino acid and “ ⌽ ” represents any ...
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A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication
... a nuclear localization sequence (NLS) at its C-terminus, targeting Gag to the nucleus early after infection ...in nuclear import of pre-integra- tion complexes [12], it determines multiple ...
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Novel Nuclear Export Signal-Interacting Protein, NESI, Critical for the Assembly of Hepatitis Delta Virus
... transferable nuclear export signal capable of directing a heterologous protein from the nucleus to the ...the nuclear export of NES(HDAg-L) and the assembly of HDV ...an ...
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Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication
... putative nuclear export signal lead to nuclear retention of NS1 at late stages of infection In order to determine the key amino acids regulating the nuclear export of NS1 protein ...
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The Nuclear Export Signal within the E4orf6 Protein of Adenovirus Type 5 Supports Virus Replication and Cytoplasmic Accumulation of Viral mRNA
... a nuclear export signal (NES) within ...this signal sequence severely reduces the ability of the E1B-55 kDa–E4orf6 complex to leave the ...when nuclear export was blocked ...
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Characterization of Functional Domains of Equine Infectious Anemia Virus Rev Suggests a Bipartite RNA-Binding Domain
... specific sequence called the Rev-responsive element (RRE) (15, 48), multimerizes (37, 47), and facilitates export of incompletely spliced RNAs from the nucleus via a nucleoporin pathway distinct from that ...
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Retroviral Constitutive Transport Element Evolved from Cellular TAP(NXF1)-Binding Sequences
... active signal of RNA nuclear export, indicating a remark- able degree of functional ...conserved sequence motifs and their analogous arrangement in the secondary ...efficient export and ...
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Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export
... CRM1-dependent export promotes S-YFP nuclear ...CRM1-dependent nuclear export ...demarcate nuclear and cytoplasmic compartments (nuclear border labeled by white dotted ...The ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... acid sequence was an important step in the present ...protein sequence to predict the most likely locations, such as in the nucleus or in the ...acid sequence of VP1 (Taiwan CIA-89) ...
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Phosphorylation meets nuclear import: a review
... of nuclear import and nuclear availability of transcription factors and certain proteins that directly affect gene expression is vital for cell proliferation and linked to human ...of nuclear ...
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The Respiratory Syncytial Virus Matrix Protein Possesses a Crm1-Mediated Nuclear Export Mechanism
... shows nuclear and cytoplasmic localization during the RSV infection ...predominantly nuclear localization of M, a find- ing possibly indicative of secondary ...into nuclear and cytoplasmic extracts, ...
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Protection from Disulfide Stress by Inhibition of Pap1 Nuclear Export in Schizosaccharomyces pombe
... drug-resistance genes, we hypothesized that Oxs1 might activate these genes directly; indeed, we found that Oxs1 can bind these promoters except when in a pap1D back- ground. This suggests Oxs1 can act as a positive ...
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The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway
... It is known that luciferase-mRNA requires the CRM1- nuclear export pathway to be expressed [29]. Since the TZM-bl infection-assay is based on the luciferase ex- pression induced upon HIV infection [28], the ...
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A Novel Class of secA Alleles That Exert a Signal-Sequence-Dependent Effect on Protein Export in Escherichia coli
... the secA307 strain, we detected a 50% increase in SecA two selections is of the same order. Nevertheless, there level, even though this allele slightly accelerated DegP is no overlap between these two sets of secA ...
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