Nuclear factor 1-A
Searching for transcriptional regulators of Ang II–induced vascular pathology
... involving nuclear factor of activated T cells, PI3K, AKT, RhoA, or myocardin, acting in concert with or independently of Ets-1, have begun to be characterized ...response factor (SRF) to the ...
5
The control of human immunodeficiency virus type 1 long terminal repeat promoter activity by retinoic acid
... 5 nuclear orphan receptors with unknown ligands, apolipoprotein A1 regulatory protein (ARP-1), v-erbA-related proteins -2 and -3 (EAR-2 and EAR-3), hepatocyte nuclear factor-4 (HNF-4), and ...
171
Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... fumarate, nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), laquinimod, and teriflunomide linked to MS, experimental autoimmune encephalomyelitis (EAE), immune system, immune function, ...
14
Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin 6 in bone infection
... osteoblast TNFR-1 induces activation of NFkB. Either deleting SpA from S. aureus or reducing TNFR-1 expression by osteoblasts prevented activation of NFkB. This is an important observation, as NFkB is a ...
8
Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
... and nuclear run-on assays demonstrated a marked reduction in ntcp gene ...treatment, nuclear binding activities of two key factors that transactivate the ntcp promoter, hepatocyte nuclear ...
10
Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.
... induces nuclear NF- k B binding activity in HL3T1 ...later nuclear extracts were prepared and assayed for binding to a labeled NF- k B-specific oligonucleotide by mobility shift ...with nuclear ...
11
Inhibitory effect of phytol on cellular senescence
... necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase ...(nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase 1), 14-3-3σ ...
9
Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... 3, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GFAP, NGFR, BDNF, NTRK1, and NTRK2 expression were assessed in the ischemic mouse ...
10
OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D
... Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and ...of nuclear factor kappa-B ligand (RANKL), receptor activator of nuclear ...
6
Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... protein 1 (Keap1) in the cytosol under un- stressed ...increased nuclear staining of Nr-f2 in surviving neurons of postmortem Parkinson's disease (PD) ...oxygenase 1 (HO-1). Nrf-2 and ...
6
An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... diseases. Nuclear factor erythroid-2-related factor 2 is a master transcription factor belonging to the leucine zipper ...protein 1 is a repressor of nuclear factor ...
9
Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening
... synthase 1; CDCFDA: 5(6)-carboxy-2’: 7’-dichlorofluorescein diacetate; DAPI: 4’:6-diamidino-2-phenylindole; DMET: drug metabolizing enzymes and transport; DMSO: dimethyl sulfoxide; DILI: drug-induced liver injury; ...
16
Calcium sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor β signaling to promote breast cancer metastasis
... Fig. 1 In vivo effects of STIM2 gain or loss on tumor growth and metastasis. a Western blots (left) and quantification of protein expression (right) showing knockdown (SH) or overexpression (OE) of STIM1 and STIM2 ...
12
Successful Allogeneic Hemopoietic Stem Cell Transplantation in a Child Who Had Anhidrotic Ectodermal Dysplasia With Immunodeficiency
... in nuclear factor B essential modulator (NEMO)/I B kinase complex and a hypermorphic mutation in inhibitor ␣ of nuclear factor B (I B ␣ ) both result in impaired nuclear ...
9
Insulin promoter factor 1 gene mutation linked to early onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
... In our earlier report we described the Pro63fsdelC muta- tion as an inactivating mutation resulting in the premature termination of the translation of IPF-1 (7). This premature ter- mination prevented the ...
11
Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients
... Table 1 shows that several patients had their last seizure several days before the sur- gery, suggesting that the high TNF expression levels were frequent, signaling that chronic hippocampal inflammation could be ...
7
Nuclear Accumulation of the GATA Factor AreA in Response to Complete Nitrogen Starvation by Regulation of Nuclear Export
... transcription factor inside the nucleus may result in high-level expression of target genes, although we cannot exclude the possibility that additional changes to AreA upon nitrogen star- vation act to enhance its ...
8
Changes in Monocyte Chemoattractive Protein, Nuclear Respiratory Factor 2, B-Cell Leukemia/Lymphoma 2 and Cholinesterase in Serum of Autistic Children
... transcription factor nuclear respiratory factor 2 (NRF-2), the antiapoptotic factor -cell leukemia/lymphoma 2 (Bcl2) as well as cholinesterase activity were measured in serum of autistic ...
8
A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
... de-SUMOylation seems important for the architecture and function of the nuclear bodies. In fact, manipula- tions of SENPs show distinct effects on PML-NBs. It has been shown that IL6 cytokine induces the ...
17
Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts
... In order to evaluate the activity of ethanol on collagen syn- thesis in human skin fibroblasts, the cells were incubated for 24 hours in 25, 50, and 100 mM of ethanol as well as in ethanol with HA at concentration of 500 ...
9