Nuclear factor-erythroid 2 related factor-2 (Nrf2) and bone
Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2
... counterstaining was performed with 4′,6- diamidino-2′-phenylindole dihydrochloride (DAPI). Finally, the stained sections were examined under fluorescence microscope by a researcher who was blinded to the ...
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Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis
... balance, nuclear Nrf2 expression, and fibroblast phenotype (a-smooth muscle actin and collagen I expression, proliferation, migration, and contraction) were studied under basal conditions and after Nrf2 knockdown ...
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Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) as a Therapeutical Target in Type-2 Diabetes Mellitus: a Review
... is related to its role in increasing the release of Nrf2 from its bond with Keap1 into the nucleus, to activate ...or 2 which binds to the ARE/EpRE will activate the genes of antioxidative enzymes which are ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... NF, nuclear factor; NQO1, NAD(P)H:- quinone oxidoreductase 1; Nrf2, nuclear factor erythroid 2-related factor ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... affected. 2–4 Serial magnetic resonance imaging disputes the notion of sharply defined relapses and remissions in MS, with mounting evidence that progressive changes can occur without clinical ...tion ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... pathways related to oxidative stress is likely to become potential targets for cancer ...transcription factor and plays a critical coordinator as regulating the re- dox balance and protecting cells against ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... transcription factor also found as HB in the NCPI, ubiquitously expressed in organs ...processes related to nickel-induced toxicity [102], and other biological pro- cesses such as the cell cycle, apoptosis, ...
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Nuclear Factor Erythroid 2 Related Factor 2 Deficiency Results in Amplification of the Liver Fat-Lowering Effect of Estrogen s
... Discussion These studies identified Nrf2 as a potent suppressor of estrogen signaling in the liver. We provided two pieces of evidence to support our notion. First, in a homeostasis condition, Nrf2 deficiency resulted in ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... the nuclear factor erythroid 2-related factor 2 (Nrf2) activates expression of cytoprotective genes to enable cell adaptation to protect against oxidative ...
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The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia
... Result and Discussion Morphologically the results of observations of the influence of nimodipine on Nrf2 activation in neuron cell cultures exposed to hyperglycemia at various concentrations are shown in Figures 1, ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... (COPD), Nuclear factor erythroid 2-related factor 2 (Nrf2), Oxidative stress, Apoptosis, Epithelial cell, N-acetyl cysteine (NAC), Cigarette smoke extract (CSE), ...
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Role of Nuclear Factor E2 Related Factor 2 (Nrf2) in Environmental Chemical Induced Steatosis and Adipogenesis
... type 2 diabetes, cirrhosis, and hepatocellular carcinoma along with difficulty in diagnosis and lack of exact therapeutic intervention for these conditions make NAFLD a serious public health ...
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Role of Nuclear Factor E2 Related Factor 2 (NRF2) in Development of Steatosis and Drug Transporter Alterations
... 4.1 Abstract: Obesity is a global pandemic, spanning over 35% of the US population. Various mouse models of obesity have been proposed and are used in the pharmacokinetic studies. Diet-induced obese (DIO) mice are diet ...
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The stress signalling pathway nuclear factor E2-related factor 2 is activated in the liver of sows during lactation
... Hillen 2 , Sabrina Becker 2 , Georg Erhardt 3 , Gerald Reiner 2 and Klaus Eder 1* Abstract Background: It has recently been shown that the lactation-induced inflammatory state in the liver of dairy ...
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Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles
... TBARS is well-established biological indicators of oxidative stress 26 . The extent of lipid peroxidation reflects key pathological and toxicological states related to oxidative stress 27 . A growing body of ...
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Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury
... Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America. *Current address: Department of Hepatobiliary-Pancreatic Surgery, Lihuili ...
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Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats
... Rats were anaesthetized with 10 % chloral hydrate (3 ml/kg, i.p) and then perfused transcardially with 0.9 % saline at 4 °C followed by 4 % paraformaldehyde in phos- phate buffered saline (PBS 0.1 mol/L, pH 7.4). Regions ...
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Radix puerariae extracts ameliorate paraquat induced pulmonary fibrosis by attenuating follistatin like 1 and nuclear factor erythroid 2p45 related factor 2 signalling pathways through downregulation of miRNA 21 expression
... growth factor- β 1 (TGF- β 1), connective tissue growth factor (CTGF), collagen-1 and collagen III were measured by real-time ...(HO-1), nuclear factor erythroid 2p45-related ...
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Donor variability may mask dimethyl fumarate’s effects on nuclear factor E2 related factor 2 in human peripheral blood mononuclear cells
... Moderate responders: Nrf2 increases modestly at 2 h but drops below UNT by 4 h. Sustained responders: Nrf2 robustly activated at 2 h, remains above UNT at 4 h. Center lines show the medians; box limits ...
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Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... Of note, activation of Nrf2 in T cells by tert - butylhydroquinone (tBHQ), inhibits production of the Th1 cytokine, IFN-γ [56]. Maicas et al. reported that deficiency of Nrf2 resulted in increased migration of ...
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