Nuclear factor kappa B inhibitor
Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain
... post-translation inhibitor of NF- κ B action may constitute a new approach that will not only increase the efficacy of hormonal treatment in inducing long-lasting amenorrhea but will also reduce ...
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Arenavirus Nucleoproteins Prevent Activation of Nuclear Factor Kappa B
... B converge on the IKK kinase complex, which acts as a master reg- ulator of NF- B ... B is initiated by binding of TNF-␣ to its receptors, TNFR1 and TNFR2, which results in activation of IKK ␣ ...
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Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... an inhibitor of nuclear factor kappa light chain en- hancer of activated B cells (NF-κB), on the radiosensitivity of human pancreatic cancer cell line Sw1990, and to explore the ...
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IAP proteins as targets for drug development in oncology
... IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; IAPs, inhibitors of apoptosis; IL, interleukin; IKK, IκB kinase complex; LUBAC, linear ...
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A new piece of an old puzzle: lack of association between C-Rel (rs13031237-rs842647) single nucleotide polymorphisms and non-segmental vitiligo
... : Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; IKKb: Inhibitor of nuclear factor kappa-B kinase; IL: ...
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Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis.
... and nuclear fractions were immunoblotted for p65-NF-jB, nucleoporing-p62 (a nuclear marker), and b-actin (a cytoplasmic ...an inhibitor of NF-jB activation, was ...NOX inhibitor, ...
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The expression of inhibitor of nuclear factor kappa-B kinase epsilon (IKKe) in human aortic aneurysm
... Background: Aortic aneurysm (AA) is one of the most common causes of sud- den death among elderly people. Although AA can be detected by non-invasive imaging techniques, there are no pharmacological treatments currently ...
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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
... k B/Rel family are critical for inducible expression of multiple genes involved in in- flammatory ...scription factor NF- k B is a target of sulfasalazine-mediated ...k B activation. NF- k ...
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Targeting nuclear factor kappa B to overcome resistance to chemotherapy
... NF-κB inhibitor, Bay 11-7085, completely abrogated the apop- totic effects of cisplatin, indicating a pro-apoptotic role for NF-κB in this cell line (Chung et ...
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Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells
... can significantly suppress the proliferation, colony forma- tion, and invasion of gastric cancer cells in a dose-dependent manner (Figures 5 and 6) as well as arrest the cell cycle at the G 2 /M phase (Figure 7) and ...
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Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion
... k B dimer is present in the cytosol bound to an inhibitory protein, I k B (5, ...k B by a multitude of stimuli, in- cluding inflammatory cytokines, reactive oxygen intermedi- ates, and microorganisms ...
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Inhibition of osteoclastogenesis by RNA interference targeting RANK
... NF-kappa B: Nuclear factor `kappa-light-chain-enhancer` of activated B-cells; RANK: Receptor activator of NF- kappa B; RANKL: Receptor activator of NF- kappa ...
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The control of human immunodeficiency virus type 1 long terminal repeat promoter activity by retinoic acid
... The third group of factors comprises the coactivator proteins. These proteins are functionally described as factors that are required for activator function but do not affect activator-independent basal transcription. ...
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Effects of cannabinoids on IL 1alpha induced bovine chrondrocyte metabolism and cartilage resorption
... cysteine protease known as Interleukin 1-Converting Enzyme (ICE also known as caspase-1) is highly specific for cleaving prolL-1 p but does not cleave the IL-la precursor. Other enzymes have been found that do cleave the ...
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Cold shock proteins: from cellular mechanisms to pathophysiology and disease
... For inflammatory and fibrotic diseases, the data for the role of cold shock proteins appears more associative. The initial data came from animal studies on Ybx1 heterozy- gous mice, which express only half the amount of ...
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The role of A20 in the pathogenesis of lymphocytic malignancy
... The cloning and characterization of the A20 promoter revealed two NF-κB DNA binding elements, which are recognition sequences for NF-κB transcription factors. It was also found that multiple NF-κB activating stimuli in- ...
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Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model
... necrosis factor (TNF)α, and nuclear factor (NF)-κB), apoptotic biomarkers (caspase 3 and Bax), endoplasmic reticulum stress (ERS) and autophagy- related proteins (GRP78, LC3A/B, and Beclin1), ...
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PubMedCentral-PMC5655742.pdf
... We identified involvement of TNF first using the H/R stressed NY1DD mice that developed increased expression of both TF and VCAM-1 (Figure 2A,B, bars 2), compared to baseline expression in unstressed control NY1DD ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... correlation factor R > ...and B lymphocyte growth factor interleukin 2 (IL2), leukocyte modulator chemok- ine ligand 20 (CCL20) and cell adhesion molecule sialyl- transferase 8A ...regulatory ...
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An Update on Pathophysiology and Medical Management of Endometriosis
... growth factor inhibitor ,which have been shown to exert anti-angiogenic effects on endometriotic lesions, ...growth factor, FGFR, fibroblast growth factor receptor; HIF, hypoxia inducible ...
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