nuclear factor kappa light chain enhancer of B cells
Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... growth factor receptor; FOXO, forkhead box; iGF1R, insulin like growth factor 1 receptor; HMGB1, high mobility group protein B1; iKK, ikB kinase; iL, interleukin; iR, insulin receptor; MAPK, mitogen ...
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Significance of glioma associated oncogene homolog 1 (GLI1)expression in claudin low breast cancer and crosstalk with the nuclear factor kappa light chain enhancer of activated B cells (NFκB) pathway
... The nuclear factor kappa-light-chain-enhancer of acti- vated B cells (NFκB) pathway plays a role in inflamma- tion, cell survival, and transformation in response to ...
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Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model
... as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/ hemeoxygenase-1 (HO-1), ...
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Inhibition of osteoclastogenesis by RNA interference targeting RANK
... NF-kappa B: Nuclear factor `kappa-light-chain-enhancer` of activated B-cells; RANK: Receptor activator of NF- kappa B; RANKL: Receptor ...
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A new piece of an old puzzle: lack of association between C-Rel (rs13031237-rs842647) single nucleotide polymorphisms and non-segmental vitiligo
... : Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; IKKb: Inhibitor of nuclear factor kappa-B kinase; IL: ...
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Anti-inflammatory effects of prunin on UVB-irradiated human keratinocytes
... of nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B), which is associated with the inflammatory response, and mRNA expression of ...
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Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... [4] nuclear factor kappa light chain enhancer of activated B cells (NF-κB) plays an important role in the development of resistance to radio- therapy in pancreatic ...
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Original Article EGCG suppresses NF- B activation induced by gastroesophageal reflux contents in human esophageal epithelial cells
... the nuclear factor kappa-light-chain- enhancer of activated B cells (NF-κB) signaling pathway in normal human esophageal epithelial cells (HEECs) and the ...
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IAP proteins as targets for drug development in oncology
... IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; IAPs, inhibitors of apoptosis; IL, interleukin; IKK, IκB kinase complex; LUBAC, ...
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Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis Via Inhibition of XIAP/NF-kB and Activation of Caspases and Death Receptor 4
... H1299 cells compared to LA or TRAIL ...as B-cell lymphoma 2 (Bcl-2), Fas-like inhibitor protein (FLIP) and X-linked inhibitor of apoptosis protein (XIAP) and enhanced the activation of pro-apoptotic ...
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Salubrinal abrogates palmitate-induced leptin resistance and endoplasmic reticulum stress via nuclear factor kappa-light-chain-enhancer of activated B cell pathway in mHypoE-44 hypothalamic neurons
... Cells were collected, and the whole cell lysates were prepared by sonication in CelLytic MT buffer from Sigma-Aldrich Co. Samples consisting of 50 µg of protein were loaded on a denaturing 4%–20% precast SDS-PAGE ...
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Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients
... growth factor 1 (somatomedin C); IML: Instituto Médico Legal; KL: Klotho; Kl −/− : Klotho knockout; LTG: lamotrigine; MRI: magnetic resonance imaging; NFkB: nuclear factor kappa B; ...
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Effects of cannabinoids on IL 1alpha induced bovine chrondrocyte metabolism and cartilage resorption
... and cells stimulated with IL-1, LPS, or TNF-a for 24 and 48 hours were shown to produce, significantly, more NO than did deep explants and cells treated the same (Hayashi et ...
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Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment Strategies
... NB4 cells, proposing a metabolic rewiring hypothesis as ATO-resistance mechanism in APL cells ...APL cells, there is evidence that after relapse and in therapy resistant NB4 cell subclones MDR and ...
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PubMedCentral-PMC5655742.pdf
... We tested the impact of drugs, transcription factor knockouts, or trans- fusion of PBMC using animals at 3.5 – 4 months of age, unless other- wise indicated. Experiments used pooled animals from multiple litters, ...
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Deubiquitinases in cancer
... [81], B-cell CLL/lymphoma 3 (Bcl-3) [82] and mitogen- activated protein kinases [83], whereas A20 promotes the degradation of TRAF2 in lysosomes by means of its own E3 ligase activity ...ubiquitin chain ...
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Non enzymatic upregulation of tissue factor expression by gamma-glutamyl transferase in human peripheral blood mononuclear cells
... Gamma-glutamyltransferase [GGT; (5-l-glutamyl)-pep- tide⁄amino acid 5-glutamyl transferase; EC 2.3.2.2], a member of the structural superfamily of the N-terminal nucleophilic hydrolases expressed by a wide number of cell ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... mitochondrial dysfunction. It has been recognized that mitochondrial deficiency accompanies the aging process, albeit the exact mechanisms for mitochondrial dysfunc- tion discussed, for example mtDNA mutations in verte- ...
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Arenavirus Nucleoproteins Prevent Activation of Nuclear Factor Kappa B
... 293T cells with the pNF- B-Fluc reporter plasmid, the pSV40-RL control vector, and LCMV-NP wild type or mutants containing alanine (A) substitutions at positions D382, I383, E384, G385, R386, D459, H517, ...
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Targeting nuclear factor kappa B to overcome resistance to chemotherapy
... The efficacy of targeted therapy is based on the oncogenic dependence of cancer cells on mutated survival and apoptotic pathways, such as NF-κB, which renders them more susceptible to inhibitors. NF-κB is a master ...
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