nuclear factor of activated T cell
Nuclear factor of activated T-cell isoform expression and regulation in human myometrium
... for cell studies, Figures 1, 2, 4 and 5 were expressed relative to the geometric mean of a panel of housekeepers (glycer- aldehyde 3-phosphate dehydrogenase (GAPDH), β-actin and β-2 microglobulin) as determined by ...
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HYPOXIA INDUCIBLE FACTOR AND OSMOREGULATORY MOLECULES AFFECT CELL BLEBBING; IMPLICATIONS FOR SENESCENCE AND AGEING PROCESS
... transcription factor for ORE/TonE was identified as TonE-binding protein (TonEBP)/ORE- binding protein (OREBP), which shows sequence homology to a family of transcription factors called the Nuclear ...
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Human T-Cell Lymphotropic Virus Type 1 p12I Expression Increases Cytoplasmic Calcium To Enhance the Activation of Nuclear Factor of Activated T Cells
... Jurkat T cells were transfected with increasing amounts of pcDNA-CRT plus 10 g of NFAT-Luc, and the NFAT luciferase activities were analyzed 18 h post-ionomycin ...Jurkat T cells were transfected with ...
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Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T cells 5 in vitro
... As our initial studies concerned adult HACs obtained from OA knee joints, we aimed at eliminating interpreta- tion bias due to the pathological state of these cells. Using identically challenged NHACs, we showed that ...
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Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus Infection
... the cell type and stimulus (10, 22, 27, 29, ...transcription factor, NFATp, to regulate TNF- ␣ expression in activated T cells by binding of two NFATp molecules to the kappa 3 element in ...
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Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML
... the nuclear factor of activated T-cells ...physiologically activated by the calcium-activated serine/threonine phosphatase calcine- urin, which dephosphorylates NFAT, thereby ...
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Investigation of the Role of Nuclear Factor of Activated T Cells (NFAT2) in T Regulatory Cell-induced Immune Suppression in Feline Immunodeficiency Virus Infection.
... The NFAT family has five members: NFAT1 (also named as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3 (NFATc4), NFAT4 (NFATx or NFATc3) and NFAT5. NFAT proteins are ubiquitously expressed by almost all types of immune ...
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Calcium sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor β signaling to promote breast cancer metastasis
... cancer cell inoculation by measuring tumor length and width with a sliding ...injection. T tests or one-way ANOVA were used to compare independent ...
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Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion
... Using cell-specific antibodies, the presence of a large num- ber of smooth muscle cells and macrophages and to a lesser ex- tent T cells was identified in the advanced atherosclerotic le- sions which we ...
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Activation of Nuclear Factor of Activated T Cells by Human T-Lymphotropic Virus Type 1 Accessory Protein p12I
... 16B12), and Flag tag (clone M2) were purchased from Covance Research Prod- ucts (Richmond, Calif.) and Sigma Chemical Corporation (St. Louis, Mo.), respectively. Monoclonal antibodies specific for phospho-ERK1/2 (clone ...
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Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-γ stimulated macrophages
... of T-helper-1 re- sponses, which is associated with the pathogenesis of chronic inflammatory ...macrophage cell line was pre-treated with vehicle or AZM, followed by the stimulation with LPS/IFN- γ ...AP-1, ...
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Aberrant Activation of the Interleukin-2 Autocrine Loop through the Nuclear Factor of Activated T Cells by Nonleukemogenic Human T-Cell Leukemia Virus Type 2 but Not by Leukemogenic Type 1 Virus
... Human T-cell leukemia virus type 1 (HTLV-1) but not HTLV-2 is associated with adult T-cell ...the nuclear factor of activated T cells (NFAT) in a human ...
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Regulation of the Transcriptional Response to Oxidative Stress in Fungi: Similarities and Differences
... oxidant-regulated nuclear localization of Yap1p has been most intensively studied, homologues of this tran- scription factor from ...regulated nuclear localization of Pap1 in ...transcription ...
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Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
... Th e transmembrane or the soluble IL-6 receptor forms a complex with two gp130 molecules after binding IL-6. Th is leads to phosphorylation of Janus protein-tyrosine kinase, which causes the activation of intracellular ...
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The role of nuclear factor of activated T cells during phorbol myristate acetate-induced cardiac differentiation of mesenchymal stem cells
... p38 mitogen-activated protein kinase (MAPK) inhibitor [4] and a bone morphogenetic protein (BMP) inhibitor [5] induced the cardiac differentiation of embryonic stem cells. Furthermore, several studies have demon- ...
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The HTLV 1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)
... visualize nuclear-cytoplasmic shuttling of molecules, co-expression of Urm1 and Tax by the UAS/GAL4-sys- tem caused a marked export of Tax out from the nucleus ...of nuclear Tax, as compared to expressing ...
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Transcriptional regulation of the mouse and human interleukin-5 genes in T-lymphocytes
... Naive T helper cells, in contrast, like Thl cells, possessed only one of the five HS ...transcription factor GATA-3 produced the same changes when transduced into differentiated Thl cells or STAT6-deficient ...
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Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy
... epithelium-derived factor (PEDF) and thrombospondin-1 (TSP-1) are secreted by RPE ...growth factor (VEGF; acts on the choroidal endothelium) and, on the apical side, PEDF (acts on neurons and ...growth ...
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(−) Epicatechin 3 O β d allopyranoside prevent ovariectomy induced bone loss in mice by suppressing RANKL induced NF κB and NFATc 1 signaling pathways
... The enzymatic activity of MMP-9 was determined using gelatin zymography. Briefly, RAW 264.7 cells were seeded and allowed to grow to confluence for 24 h, and then maintained in 1% FBS-supplemented medium with different ...
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Renal cell carcinoma–derived gangliosides suppress nuclear factor κB activation in T cells
... the nuclear translocation of Rel family ...from nuclear extracts of normal T cells was not degraded by either nuclear or cytoplasmic extracts from ganglioside-treated T ...
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