nuclear hormone receptor
The Xenopus ortholog of the nuclear hormone receptor Nr2e3 is primarily expressed in developing photoreceptors
... ABSTRACT Nr2e3 is a nuclear hormone receptor that is involved in rod photoreceptor differen- tiation. The Nr2e3 gene was previously identified in humans, mice, zebrafish and chicken. In all species, ...
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Molecular and Structural Insights into Nuclear Hormone Receptor Repression Mediated by the Corepressor NCOR
... [nuclear receptor (NR1H3) and LXRβ (NR1H2) are highly homologous members of the nuclear hormone receptor superfamily that are encoded by two distinct genes (Willy et ...orphan ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... liver-specific receptor that is required for HBV infection of ...hepatocyte nuclear factor 4 (HNF4) and the retinoid X receptor ␣ (RXR␣) plus the peroxisome proliferator-activated receptor ␣ ...
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Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein
... this receptor family share a number of structural ...termed hormone response ...the hormone (the ligand-binding domain), functions as a ligand-dependent transcriptional activation ...
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The Sf1 related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function
... When the genes that are highly regulated in reproductive tract (Table 4) were compared with those in the spermathecae (Table 3), additional evidence of an SF1-like mode of action was observed. Cyp4p2 is also ...
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Differential Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by the Small Heterodimer Partner
... Alternatively, the farnesoid X receptor (FXR) can directly activate SHP expression in the liver (Fig. 7B) (12, 21). FXR is activated by its ligands, bile acids (22, 29, 45). Conditions associated with elevated ...
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Replication of the Wild Type and a Natural Hepatitis B Virus Nucleocapsid Promoter Variant Is Differentially Regulated by Nuclear Hormone Receptors in Cell Culture
... these nuclear hormone recep- tors bound to the variant proximal nuclear hormone receptor binding site ...proximal nuclear hormone recep- tor binding sites in the ...
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The thyroid hormone nuclear receptor TRα1 controls the Notch signaling pathway and cell fate in murine intestine
... thyroid hormone nuclear receptors (TRs), which belong to the nuclear hormone receptor transcription factor superfamily (reviewed by Robinson-Rechavi et ...the hormone ...
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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA 1
... the Receptor: In accordance to the literature studies and the research carried out, the thyroid hormone receptor alpha-1(THRA1), a high affinity agonist receptor for triiodothyronine 20 , was ...
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Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat
... Quantitative reverse transcription PCR and immunohistochemistry show that there is no difference in inflamma- tion between EAT of cases and controls. We performed quantitative reverse transcription (qRT-PCR) to verify ...
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The Drosophila Eip78C Gene Is Not Vital But Has a Role in Regulating Chromosome Puffs
... Since Eip78C-B is a member of the nuclear hormone receptor superfamily that lacks a DNA binding domain, we presume that it interacts with other members of the superfami[r] ...
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Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation
... hyperactivated phenotype. In vitro T-cell proliferation and interleukin 2 signaling were impaired. CD4 ⫹ and CD25 ⫹ regulatory T cells were significantly diminished, and they probably contributed to the signs of ...
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Neuromodulators, stress and plasticity: a role for endocannabinoid signalling
... corticotropin-releasing hormone (CRH) along with other secretogogues including vasopressin (VP) into the hypophyseal portal ...adrenocorticotropic hormone (ACTH) into the general ...
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Thyroid hormone – triiodothyronine – has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) – role of E2F4, E2F5 and p107, p130
... nucleus in Caki-2 cells. In the presence of T3 there were no differences between Caki-2 and HK2 in the level of TRβ, which suggests that transport of TRs in Caki-2 is inde- pendent of T3, its known that in normal cells ...
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Chinese herb mix Tiáo Gēng Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats
... Abbreviation list E2 : estradiol; ERa: estrogen receptor alpha; ERb: estrogen receptor beta; ERs: estrogen receptors; FSH: folliclestimulating hormone; LH: luteinizing hormone; MDA: malo[r] ...
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microRNA and thyroid hormone signaling in cardiac and skeletal muscle
... Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological func‑ tion of all organs or tissues, including heart and skeletal ...
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Generation of GHR modified pigs as Laron syndrome models via a dual sgRNAs/Cas9 system and somatic cell nuclear transfer
... Methods: To further improve the GHR knockout (GHRKO) efficiency and explore the feasibility of precise DNA dele‑ tion at targeted sites, the dual‑sgRNAs/Cas9 system was designed to target GHR exon 3 in pig fetal ...
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Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ
... assessed receptor expression in subsequent invasive breast cancer following LCIS between black women and white women, identifying that black women had a signifi- cantly higher risk for ER−PR− invasive ...these ...
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Nuclear thyroid hormone receptors
... Isolation ofa cDNA encoding human Rev-ErbAa: transcription from the non-coding DNA strand of a thyroid hormone receptor gene results in a related protein which does not bind thyroid horm[r] ...
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Nuclear hormone receptors in podocytes
... The mechanisms by which aldosterone induces pro- teinuria are likely complex. However, the observation that podocytes express MR suggests a direct role of liganded MR in podocyte injury. In podocytes, aldoster- one ...
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