nuclear import
Nuclear Import of Bovine Papillomavirus Type 1 E1 Protein Is Mediated by Multiple Alpha Importins and Is Negatively Regulated by Phosphorylation near a Nuclear Localization Signal
... (48). Nuclear import assays were performed as reported previously (1, ...the nuclear import assay, a 10 M solution of the E1 protein was incubated with 50 M of Alexa-555 maleimide ...
10
Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
... IN import in our ...several import pathways have been ...one import receptor, for example, those that mediate the nuclear import of other basic cellular proteins, such as ribosomal ...
14
Nuclear import of influenza A viral ribonucleoprotein complexes is mediated by two nuclear localization sequences on viral nucleoprotein
... the nuclear import of influenza ...the nuclear import of in vitro-assembled NP- RNA complexes ...in nuclear accumulation of NP, suggesting the presence of a third NLS [32], whose ...
12
The Cargo-Binding Domain of Transportin 3 Is Required for Lentivirus Nuclear Import
... through nuclear pores to access the host genomic DNA. Several nuclear import and nuclear pore components have been implicated as playing a role in nuclear import, including ...
12
Nuclear Import of Epstein-Barr Virus Nuclear Antigen 1 Mediated by NPI-1 (Importin α5) Is Up- and Down-Regulated by Phosphorylation of the Nuclear Localization Signal for Which Lys379 and Arg380 Are Essential
... (EBV) nuclear antigen 1 (EBNA-1) is essential for replication of episomal EBV DNAs and maintenance of ...on nuclear translocation of Ser phosphorylation of the EBNA-1 nuclear localization signal ...
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Analysis of the Viral Elements Required in the Nuclear Import of HIV-1 DNA
... that nuclear entry defects were observed in viruses devoid of the same element in cycling and arrested cells may suggest that an active nuclear import through the NPC is required even in cycling ...
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Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22
... cise nuclear localization signal (NLS) and its key amino acids (aa) of P-ICP22 was identified and mapped to aa 41–60 and aa 49–50, ...of nuclear import, which are crucial for understanding ...
10
Importin alpha 1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons
... and nuclear targeting of ICP4, ICP0, ICP8 and the DNA polymerase subunit pUL42 impaired in the MEF cells lacking importin α1 or importin ...contrast, nuclear targeting of incoming capsids as well as ...
35
Baculovirus Transregulator IE1 Requires a Dimeric Nuclear Localization Element for Nuclear Import and Promoter Activation
... proper nuclear transport of IE1 is essential for productive ...IE1 nuclear import, we analyzed the effect of site-directed mutations on IE1 subcellular ...impaired nuclear import and ...
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Insertion of a Classical Nuclear Import Signal into the Matrix Domain of the Rous Sarcoma Virus Gag Protein Interferes with Virus Replication
... transient nuclear trafficking during virus assembly. Nuclear import is mediated by a nuclear targeting sequence within the MA ...of nuclear transport in replication, we investigated ...
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A role for transportin in the nuclear import of adenovirus core proteins and DNA
... either import pathway equally and evidently does not have a preference during nuclear ...V import in complete assays implies that this protein asso- ciates with additional import ...
10
Recombinant Adeno-Associated Virus Utilizes Host Cell Nuclear Import Machinery To Enter the Nucleus
... canonical nuclear entry by either directly binding to NLS-harboring cargo or interacting with cargo through an adapter importin-␣ ...in nuclear import for several viral infectious pathways, including ...
13
Inhibition of HIV 1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
... IN nuclear import is expected to result in the inhibition of virus replication, especially in cell-cycle arrested ...IN nuclear import inhibited the process of viral cDNA integration, reaching ...
16
Phosphorylation meets nuclear import: a review
... mediated nuclear export ...ERK5 nuclear accumulation ...the nuclear import of ERK5 by altering the balance between NLS/NES ...ERK5 nuclear transport, the N- and C-terminal domains are ...
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Inhibition of Nuclear Import and Alteration of Nuclear Pore Complex Composition by Rhinovirus
... mediate import in vitro ...of nuclear import induced by rhinovirus infection coin- cides with any other events in the viral life cycle, we examined the cleavage of the translation initiation factor ...
10
Nuclear import and export of influenza virus nucleoprotein.
... A nuclear localization signal (NLS) has been identified in NP at amino acids 327 to 345 ...nucleus. Nuclear localization of a protein containing amino acids 1 to 38 of NP fused to LacZ proved that these 38 ...
11
Inhibitors of the integrase–transportin SR2 interaction block HIV nuclear import
... of import factors have been implicated, most notably importin-α/β [25, 26], importin-α3 [27] and importin-7 ...HIV nuclear import, the exact mechanism of action remains a matter of ...in ...
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Nuclear import pathway of the cytokine interleukin-5 and its receptor subunits
... If it does, this should further contribute to the growing idea that polypeptide ligand/receptor nuclear import is a key means of activating specific growth factor and cytokine signalling[r] ...
196
Chikungunya virus capsid protein contains nuclear import and export signals
... control EGFP expression (1.59 ± 0.42 times nuclear). As in other alphaviruses, a substantial amount of CP was seen in nucleoli [4]. Karyopherins are known to directly interact in the cytoplasm with proteins ...
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On the role of the phosphatidylinositol transfer protein alpha in the nuclear import of phosphatidylinositol
... the nuclear matrix of mammalian cells is ...purified nuclear fractions, depleted of nuclear envelope and cellular debris using detergents (“endonuclear” ...the nuclear space, but also impact ...
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