Nuclear localization signal
Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition
... a nuclear localization ...a nuclear localization signal (NLS) and in template binding is also involved in nucleo- tide recognition and can affect the incorporation of nucleotide ...
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Nuclear Import of Bovine Papillomavirus Type 1 E1 Protein Is Mediated by Multiple Alpha Importins and Is Negatively Regulated by Phosphorylation near a Nuclear Localization Signal
... its nuclear localization signal but not to importins ␣ 1 and ␣ ...the nuclear import of BPV1 E1 has been ...E1 nuclear import (28, ...
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Characterization of the Nuclear Localization Signal of the Borna Disease Virus Polymerase
... specific nuclear localization signal(s) (NLS[s]) within the primary amino acid sequence of the karyophilic protein ...the nuclear pore complex and is im- ported into the nucleus through a ...
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Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin
... here, nuclear localization signal (NLS)- modified polymeric micelles were studied with the aim of improving nuclear drug ...proton nuclear magnetic resonance spectroscopy, dynamic light ...
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A Nuclear Localization Signal in Herpesvirus Protein VP1-2 Is Essential for Infection via Capsid Routing to the Nuclear Pore
... Growth characteristics of K.VP1-2 ⌬ NLS. We previously identi- fied a short, highly conserved basic motif in VP1-2, embedded within an otherwise poorly conserved region at the N terminus of the protein (Fig. 1a). We ...
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Biologic and Immunologic Effects of Knockout of Human Cytomegalovirus pp65 Nuclear Localization Signal
... prototypic nuclear localization signal (NLS) in which arginine and lysine predominate within a bipartite motif in which short regions of basic amino acids are separated by 10 or more nonconserved ...
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The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.
... Functionally important domains in the SV40 large TAg sequence are identified, including the nuclear localization signal and several phosphorylation sites, among them the site for p34cdc2[r] ...
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Analysis of a nuclear localization signal of simian virus 40 major capsid protein Vp1.
... The nuclear localization signal of the major structural protein, Vp1, of simian virus 40 was further defined by ...Vp1 nuclear localization signal functioned autonomously without ...
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Nuclear Import of Epstein-Barr Virus Nuclear Antigen 1 Mediated by NPI-1 (Importin α5) Is Up- and Down-Regulated by Phosphorylation of the Nuclear Localization Signal for Which Lys379 and Arg380 Are Essential
... (EBV) nuclear antigen 1 (EBNA-1) is essential for replication of episomal EBV DNAs and maintenance of ...on nuclear translocation of Ser phosphorylation of the EBNA-1 nuclear localization ...
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Inhibition of Human Cytomegalovirus Replication via Peptide Aptamers Directed against the Nonconventional Nuclear Localization Signal of the Essential Viral Replication Factor pUL84
... replication. Nuclear trafficking of pUL84 is facilitated by a complex nonconventional nuclear localization signal (NLS) that mediates its inter- action with the cellular importin- ␣ /  ...the ...
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Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS
... non-classical signal sequences of experimentally proven nuclear ...a nuclear localization signal, we constructed two different fusion proteins using the vector enhanced green ...
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Functional exchangeability of the nuclear localization signal (NLS) of capsid protein between PCV1 and PCV2 in vitro: Implications for the role of NLS in viral replication
... the nuclear accumu- lation of PCV1 and PCV2 capsid protein are properly mediated by their distinct NLS motifs ...to nuclear accumulation of capsid ...the nuclear localization signal ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... subcellular localization of viral proteins, especially in the nucleus, may contribute to cell apoptosis, viral replication or host cell proliferation [9, ...the nuclear localization signal ...
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Oxadiazols: a New Class of Rationally Designed Anti-Human Immunodeficiency Virus Compounds Targeting the Nuclear Localization Signal of the Viral Matrix Protein
... of nuclear translo- cation of the HIV preintegration ...HIV-1 nuclear import by targeting the nuclear localization signal (NLS) in the matrix protein ...inhibited nuclear import ...
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The role of nuclear localization signal in parvovirus life cycle
... for nuclear targeting of VP2 ...the nuclear localization signal of B19 VP2 capsid protein, the localization of full-length VP2 (aa VP 228-781) protein and a C-terminal, truncated form ...
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Functional Characterization of the Nuclear Localization Signal for a Suppressor of Posttranscriptional Gene Silencing
... these mutant viruses retained the ability to replicate in proto- plasts (18). TYLCV-C infection, and indeed transient expres- sion of the C2 protein via agroinfiltration, effectively overcame the local and systemic ...
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Nuclear Localization Signal of HIV-1 as a Novel Target for Therapeutic Intervention
... (1992) Active nuclear import of human immunodeficiency virus type 1 preintegra- tion complex. Stevenson M, Bukrinsky M, Haggerty S[r] ...
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Interaction of the Vp3 Nuclear Localization Signal with the Importin α2/β Heterodimer Directs Nuclear Entry of Infecting Simian Virus 40
... the nuclear entry of a nucleopro- tein complex involves a dynamic interplay among distinct res- ident NLSs residing in the ...The nuclear entry signal of the infecting SV40, which is a multisubunit ...
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Inhibition of HIV 1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
... 5). Nuclear fluorescence was also detected following transfor- mation with either GN-180-IN or GN-NLS-IN and GC- Impα ...fluorescent signal (Fig. 5). It has been well established that nuclear import ...
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Differential Intracellular Compartmentalization of Herpetic Thymidine Kinases (TKs) in TK Gene-Transfected Tumor Cells: Molecular Characterization of the Nuclear Localization Signal of Herpes Simplex Virus Type 1 TK
... the nuclear localization of HSV-1 TK is crucial for reactivation and also that changing the intracellular localization of HSV-1 TK from the nucleus to the cytosol (by deleting the NLS) would affect ...
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