nuclear translocation
Nuclear Translocation Sequence and Region in Autographa californica Multiple Nucleopolyhedrovirus ME53 That Are Important for Optimal Baculovirus Production
... Protein nuclear import typically requires a nuclear localization signal (NLS), which normally consists of a short cluster of posi- tively charged arginine and/or lysine residues or a short sequence of basic ...
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COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization
... As nuclear localization proteins, EGFR/ EGFRvIII can activate STAT3 and STAT5 through its tyrosine kinase function during nuclear translocation and can act as transcription factors in the nucleus, ...
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Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
... the nuclear localization of IRF3 and NF- B by ...the nuclear transport proteins KPNA2, KPNA3, and KPNA4, which competitively blocked the in- teraction of KPNA3 and KPNA4 with their cargo molecules, IRF3 ...
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Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
... for nuclear import of HIV-1, we solved new crystal structures of hexameric HIV-1 capsid in complex with a Nup153- derived peptide containing a phenylalanine-glycine repeat (FG repeat), which we used to guide ...
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Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation.
... Airway epithelial cells represent the principal initiators of pulmonary host defense mechanisms by their ability to synthe- size and secrete inflammatory mediators upon injury or infec- tion. The immunomodulatory ...
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Basic Residues of the Helix Six Domain of Influenza Virus M1 Involved in Nuclear Translocation of M1 Can Be Replaced by PTAP and YPDL Late Assembly Domain Motifs
... if nuclear translocation of M1 provided by the NLS is a critical functional requirement for virus growth and ...in, nuclear entry of M1. However, NLS may aid in nuclear retention of M1 by ...
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Glucocorticoid Receptor Nuclear Translocation in CD4 T Cells from Severe and Moderate Asthmatic Patients Treated with Fluticasone/Vilanterol
... (GR) nuclear translocation in CD4 T cells treated with fluticasone furoate (FF), vilanterol (V) and FF/V combination in severe asthmatic patients compare to patients with moderate asthma and healthy ...
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Adenovirus-Facilitated Nuclear Translocation of Adeno-Associated Virus Type 2
... AAV translocation into the nucleus by changing the function of the ...the nuclear pore when cells are maintained in calcium free medium (12, ...the nuclear move- ment of 10-kDa dextran fluorescently ...
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DNA damage induces nuclear translocation of parkin
... damage. Nuclear translocation of parkin appears to be required to promote DNA ...induces nuclear translocation of parkin leading to the PCNA interaction and possibly other nuclear ...
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Potential of new anti cancer agents targeting the nuclear translocation signaling of HB EGF C terminal fragments during the development of colitis associated cancer
... Angiotensin II, a GPCR agonist, also induces EGFR transactivation [32]. Both telmisartan and candesartan are antagonists of AT1R (a GPCR), raising the possibi- lity that the TPA-induced nuclear ...
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Original Article Hyperthermia induced the apoptosis of esophageal squamous cell carcinoma cells and affected the nuclear translocation of Nrf2
... that nuclear pro- teins were most sensitive and a high degree of correlation between nuclear protein aggrega- tion and heat-induced cell kill ...some nuclear proteins and make them out of the ...the ...
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Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway
... the nuclear translocation of NF-κB p65 and the expression of IκBα, whose degradation and phosphorylation makes NF-κB p65 release and transfer into the nuclear ...
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Kaposi's Sarcoma-Associated Herpesvirus-Induced Angiogenin Plays Roles in Latency via the Phospholipase Cγ Pathway: Blocking Angiogenin Inhibits Latent Gene Expression and Induces the Lytic Cycle
... The viral and host factors dictating KSHV latency mainte- nance, lytic cycle control, and the switch to the lytic cycle are the most sought after questions in the KSHV field and remain to be fully understood (13). Since ...
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Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling
... Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and ...
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RHCG Suppresses Tumorigenicity and Metastasis in Esophageal Squamous Cell Carcinoma via Inhibiting NF-κB Signaling and MMP1 Expression
... the nuclear translocation of p65 ...the nuclear import of p65, was applied to block this ...p65 nuclear translocation was significantly blocked in RHCG-silenced cells after treatment ...
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TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer
... nuclear translocation. When TBC1D8 was overexpressed in OVCAR cells, the nuclear PKM2 signal was increased (Figure 6A), whereas silencing TBC1D8 expression markedly decreased the nuclear PKM2 ...
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Central Role of the NF-κB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation
... RelA nuclear translocation, an ⬃ 16-fold increase in phospho-Ser2 RNA Pol II formation, and a 12-fold increase in H3K122 Ac ...RelA nuclear translocation and phospho-Ser2 RNA Pol II and H3K122 ...
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Original Article Morphoproteomic confirmation of an activated nuclear factor- Bp65 pathway in follicular thyroid carcinoma
... of nuclear factor (NF)-кBp65 pathway in the pathogenesis of follicular thyroid carcinoma (FTC) has not been fully ...Both nuclear and cytoplasmic immunoreactivities with p-NF-кBp65 (Ser 536) antibodies were ...
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Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus
... the nuclear translocation of signal transducer and activator of transcription protein 1 (STAT1) in interferon (IFN)-stimulated gene expres- sion (9, 10); KPNA1 and KPNA6 transport STAT3 (11) to activate the ...
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Original Article Paricalcitol prevents glucose induced-podocyte injury by inhibiting Wnt/β-catenin pathway
... Abstract: Previous reports found that vitamin D analog Paricalcitol can inhibit β-catenin, we tested whether parcial- citol could ameliorate glucose-induced podocyte injury. The podocytes MPC5 cells were treated and ...
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