Nuclear β-catenin
Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent
... of β-catenin. In Caenorhabditis elegans, there appear distinct β-catenin homologues for adhesion and signalling functions [11, 57] and in Xenopus laevis embryos, over-expression of cadherins ...
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c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors
... of β-catenin and c-Cbl expression in the full cohort of 83 CRC ...of nuclear β-catenin and ...and nuclear β-catenin was observed in 83 CRC patients (p < ...and ...
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Original Article The expression of S100P increases and promotes cellular proliferation by increasing nuclear translocation of β-catenin in endometrial cancer
... kit-8. Nuclear β-catenin protein level was detected by western ...by β-catenin was detected by real-time quantitative ...ability, nuclear β-catenin protein level, ...
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Revitalising the rudimentary replacement dentition in the mouse
... by nuclear localisation of β -catenin in both the epithelium and surrounding mesenchyme when viewed at high power ...with nuclear β -catenin, indicating absence of canonical Wnt ...
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Aberrant nuclear localization of β catenin without genetic alterations in β catenin or Axin genes in esophageal cancer
... with nuclear β -catenin ...for β-catenin were ini- tial denaturation for 5 min at 95°C, followed by 38 cycles of denaturation at 94°C for 30 sec, annealing at 56°C for 30 sec, extension ...
9
Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer
... cytoskeleton. β-catenin is an integral member of adherens junctions that regulates the cellular dynamics of cell attachment or detachment ...[19]. β-catenin has dual roles within the cell - as ...
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Localization of planarian β CATENIN 1 reveals multiple roles during anterior posterior regeneration and organogenesis
... of β -catenin-1 itself (Adell et ...after β -catenin-1(RNAi) depends on the time and dose of inhibition (Adell et ...Although β -CATENIN-1 is widely present in specific organs of ...
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Simplet/Fam53b is required for Wnt signal transduction by regulating β catenin nuclear localization
... stabilized β -catenin; pBAR, stabilized β -catenin and full-length SMP; or pBAR, stabilized β -catenin and SMP lacking the first homology domain (SMP- Δ ...shows nuclear ...
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Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP- PNET4 clinical trial
... for β-catenin nuclear accumulation, with CTNNB1 status also ...(nuclear β-catenin accumulation) and non-MB WNT medulloblastoma ...
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Case Report Squamous cell carcinoma of the lung with highly proliferating fibromatosis-like stroma: a rare phenomenon
... of β-catenin, TGF-β, Smad, several types of chemokine ligands, and MMPs plays an important role [16, ...First, β-catenin is often expressed at least focally in deep and superficial ...
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The role of WNT /β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines
... of β-catenin expression and higher nuclear distribution in proliferative cells, as assessed by both immunofluorescence and western blot analyses (Figure 3 and Supplementary Figure ...abundant ...
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Differential stability of β catenin along the animal vegetal axis of the sea urchin embryo mediated by dishevelled
... regions, respectively. Localized degradation of GSK3β has been proposed as a mechanism for regulating nuclear accumulation of β-catenin in the early Xenopus embryo (Dominguez and Green, 2000). We ...
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NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation
... Immunostaining was performed on paraffin-embedded 4 μm sections, which were deparaffinized in xylene and rehydrated. Antigen retrieval was performed by submerging the sections in a 10 μmol/L citrate buffer solution (pH ...
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Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy
... survivin, β- catenin, p-β-catenin (Ser675) (CST, USA), Bcl-2, Bax (Proteintech, China), cleaved Caspase-3 (BioWorld, USA), FoxP3 (Abcam, ...
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Maternal β catenin and E cadherin in mouse development
... truncated β-catenin undergo normal maturation, fertilization and early 2-cell stage development, we suggest that the WNT/β-catenin signaling pathway is not functional at this time in ...that ...
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Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance
... An important goal of ongoing research is to predict the response of HCC tumors to embolization therapies. It has been demonstrated that there is no statistically significant difference in the overall survival of HCC ...
13
Original Article FAT1 inhibits the proliferation and metastasis of cervical cancer cells by binding β-catenin
... the β-catenin-mediated transcription of target ...phosphorylated β-catenin and E-cadherin protein and inhibited the expression of vimentin, TWIST, and several downstream targets of ...
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Inactivation of nuclear Wnt β catenin signaling limits blastocyst competency for implantation
... to nuclear translocation and stabilization of  -catenin, which then interacts with T-cell/lymphoid enhancer-binding (Tcf/Lef) transcription factors to influence transcription of target genes (Gordon and ...
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RhoA/ROCK Signaling Regulates TGFβ-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through MRTF-A
... Transforming growth factor (TGF)-β has been implicated in ASC and PCO, and both its active and latent forms have been detected in the aqueous humor of the anterior chamber of the eye (14,15) in response to ...
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<p>Wnt3a Inhibitor Attenuates Remifentanil-Induced Hyperalgesia via Downregulating Spinal NMDA Receptor in Rats</p>
... sion in animals. 33 In this research, both wnt antagonist iwp-2 and NMDA antagonist were found to enhance the phosphor- ylation of GSK-3 β (Ser9) and subsequently lessen the expres- sion of c-fos, NR2B and NF- κ B ...
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