nucleos(t)ide analogs
3′-Azido-3′-Deoxythymidine (AZT) Mediates Cross-Resistance to Nucleoside Analogs in the Case of AZT-Resistant Human Immunodeficiency Virus Type 1 Variants
... Future studies on this AZT-mediated resistance will focus on the effects of altered AZT metabolism on cross-resistance by AZT-resistant HIV-1 to other nucleoside analogs. AZT metabolism will be manipulated ...
8
A Mammalian-Like DNA Damage Response of Fission Yeast to Nucleoside Analogs
... of nucleoside analogs such as BrdU, FdU, and IdU (Sivakumar et ...BrdU analogs show toxicity at much lower doses and may activate a Rad3 (ATR/Mec1)-dependent damage response pathway (Hodson et ...
21
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells
... Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of checkpoint kinase 1 (Chk1), a pivotal regulator of replication. ...
16
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA.
... of nucleoside ana- logs on HIV-1 reverse transcription in both quiescent and PHA-stimulated PBMC as well as in cell-free RT ...that nucleoside analogs (AZT, ddI, or 3TC) exerted major reductions in ...
9
<p>Assessment of microRNA expression in leukemic cells as predictors of sensitivity to purine nucleoside analogs, fludarabine and cladribine, in chronic lymphocytic leukemia patients</p>
... Background: Great progress has been achieved lately in the therapy for chronic lympho- cytic leukemia (CLL), one of the most frequently diagnosed adult leukemias. New classes of drugs, such as kinase inhibitors and BCL-2 ...
11
Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin A new strategy for cancer chemotherapy
... antineoplastic activity depends on their conversion to tiazofurin-adenine dinucleotide and selenazofurin-adenine dinucleotide which are analogs of NAD. The present study was conducted to determine whether these ...
9
The Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation I132M Confers Hypersensitivity to Nucleoside Analogs
... The I132M mutation in HIV-1 RT was identified in a phe- notypic screen of clinical HIV-1 isolates from patients for whom therapy containing an NNRTI was failing (6, 16), and we previously demonstrated that this mutation ...
8
Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
... N onnucleoside reverse transcriptase inhibitors (NNRTIs), which target the essential viral enzyme reverse transcriptase (RT), have been an integral part of human immunodeficiency virus type 1 (HIV-1) therapy since they ...
18
Diverse models for anti-HIV activity of purine nucleoside analogs
... Diverse techniques such as DT, RF, SVM, and MAA were successfully used to develop models for anti-HIV purine nucleoside analogs. Models based on DT, RF, and SVM statistical approaches show an accuracy of ...
10
Effective Lethal Mutagenesis of Influenza Virus by Three Nucleoside Analogs
... of lethal mutagenesis is a reduction in the specific infectivity of a viral population. As mutations induced by the drugs accumulate in progeny genomes, fewer of the corresponding virions maintain infectivity. We ...
14
Synergistic antitumor effect of adenovirus armed with <em>Drosophila melanogaster</em> deoxyribonucleoside kinase and nucleoside analogs for human breast carcinoma in vitro and in vivo
... tion and then infected with pZD55–dNK, pZD55, DL1520, or WtAd (MOI = 1). Virus inocula were gotten rid of after 2 hours. The cells were rinsed twice with PBS and incubated at 37 ° C for 3 days, and treated with ...
12
MUTATIONS INDUCED IN ARABIDOPSIS BY DNA NUCLEOSIDE ANALOGS
... I n addition to these clear mutants, about 10% of the analog treated families and about 5 % of the controls segregated abnormal plants in the progeny (M,).. These were char[r] ...
9
Nucleoside and Nucleobase Transporters in Parasitic Protozoa
... distinct nucleoside transporters with nonoverlapping substrate specificities that mediated the up- take of adenosine and the pyrimidine nucleosides in one case and of inosine and guanosine in the other ...
10
“Synthesis of Curcumin Analogs” by Ritmaleni, Indonesia.
... curcumin analogs 6 also have been successfully synthesized by using two different aldehydes with ...curcumin analogs as 1,3-diketone analogs 8 as anticancer agent have been synthesized by Amolin ...
6
Anti Plasmodium activity of ceramide analogs
... Interestingly, the absence of a fatty acyl carbonyl group (methylene linkage) in our ceramide analogs is a critical factor for the efficacy of their antiplasmodial activity. Sphingolipids preferentially interact ...
10
A review of the use of somatostatin analogs in oncology
... somatostatin analogs alone or in combination with other agents have limited antitumoral ...Somatostatin analogs have not been shown to induce an obvious decrease in tumor burden in SCLC, but could control ...
13
A Novel and Fast Purification Method for Nucleoside Transporters
... For a long time, the low yield of membrane proteins has presented a major obstacle for their structural and functional studies, especially for NTs. Many attempts have been made to overcome this problem using various ...
9
A novel and fast purification method for nucleoside transporters
... For a long time, the low yield of membrane proteins has presented a major obstacle for their structural and functional studies, especially for NTs. Many attempts have been made to overcome this problem using various ...
8
Nucleoside Lipid Based Nanocarriers for Sorafenib Delivery
... Although the application of sorafenib, a small inhibitor of tyrosine protein kinases, to cancer treatments remains a worldwide option in chemotherapy, novel strategies are needed to address the low water solubility (< ...
8
Benzimidazole nucleoside analogues as potential antiherpetic agents
... to nucleoside analogues in which the attachment to the benzimidazole (base) is via an N-C (natural) or an N-O-C (unnatural) linkage; both are theoretically ...
158