Nucleoside analog
Genotypic resistance profiles in Chinese patients with chronic hepatitis B virus infection and the efficacy of nucleoside analog rescue therapy
... Patients and methods: Patients with initial antiviral therapy failure were recruited between January 2011 and January 2013 from the Division of Infectious Disease, West China Hospital, Sichuan University, Chengdu, ...
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Identification of a nucleoside analog active against adenosine kinase–expressing plasma cell malignancies
... purine nucleoside biosynthesis, we can postulate a model whereby enhanced ADK expression levels in sensitive cells effectively carry out rapid drug activation, enabling it to reach its “true” target(s) within the ...
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Comparative Selection of the K65R and M184V/I Mutations in Human Immunodeficiency Virus Type 1-Infected Patients Enrolled in a Trial of First-Line Triple-Nucleoside Analog Therapy (Tonus IMEA 021)
... The treatment aim for human immunodeficiency virus (HIV) infection is to durably suppress viral replication, pre- venting morbidity and mortality. Despite the availability of several antiretroviral classes and of several ...
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Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein
... 20 Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein 2 ˜ SOLANGE PETERS,1 MIGUEL MUNOZ, SABINE YERLY,3 VICTOR SA[r] ...
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Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk
... Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zal- citabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically ...
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Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase.
... Nucleoside analog resistance in human immunodeficiency virus type 1 results from mutations in reverse transcriptase (RT) that allow the enzyme to discriminate against such ...
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Nucleoside Analog Resistance Caused by Insertions in the Fingers of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involves ATP-Mediated Excision
... volves an enhanced discrimination at the incorporation step and usually arises by either an M184I or M184V mutation in HIV-1 RT; both of these mutations selectively interfere with the incorporation of 3TCTP. The ...
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NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3
... DDX3 is a multifunctional protein that belongs to the aspartate-glutamate-alanine-aspartate (D-E- A-D) box RNA helicase family [10, 11]. The putative functions of DDX3 have been associated with a variety of cellular ...
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<p>Enhancing Antitumor Efficacy of Nucleoside Analog 5-Fluorodeoxyuridine on HER2-Overexpressing Breast Cancer by Affibody-Engineered DNA Nanoparticle</p>
... loading nucleoside analogue ...other nucleoside analogues, such as gemcitabine, decitabine and clofarabine, and utilizing other types of af fi body molecules as targeting ligand for this nanocarrier will ...
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Antiviral Drugs from the Nucleoside Analog Family Block Volume-Activated Chloride Channels
... AZT and acyclovir block the swelling-induced chloride current and regulatory volume decrease (RVD) in the human T cell lymphoma cell line H9.. (a) In H9 cells (puilse protocol see Fig. l[r] ...
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Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus
... Lassa fever has emerged as a worldwide concern among public health officials because of the ability of Lassa virus to spread from person to person, risk of its importation by international travel, and renewed threats ...
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Purine Transport and Metabolism in Microvascular Endothelial Cells
... equilibrative nucleoside transporters (SLC29; ENTs) and concentrative nucleoside transporters (SLC28; CNTs) (4; ...These nucleoside transporters (NTs) have roles in salvaging endogenous nucleosides, ...
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RECENT ADVANCES AND MANAGEMENT APPRAISAL FOR THE CHEMOTHERAPY OF AIDS
... The viral target sites at which current treatment strategies aimed are entry inhibitors, reverse transcriptase inhibitors represented by the nucleoside analog reverse [r] ...
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Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness
... particular, nucleoside/tide derivatives are a backbone of treatment for HIV/AIDS and for chronic hepatitis B virus (HBV) infection (3), with the nucleotide derivative sofosbuvir acting to revolutionize the ...
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Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... Increased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate wit[r] ...
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Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002
... inhibitors, nucleoside and non-nucleoside reverse transcriptase inhibitors were found in 10 (12%), 42 (48%) and 19 (21%) patients, ...to nucleoside reverse transcriptase inhibitors was prevalent in ...
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Analog and digital to analog tunable integrators
... of analog and digital-to-analog tunable integrators, especially their construction and operation, the definition of the uniqueness of each scheme, both in circuit engineering execution, and by the process ...
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Cytosine Arabinoside Influx and Nucleoside Transport Sites in Acute Leukemia
... of nucleoside transport sites was estimated for each cell type by measuring the equilibrium binding of [ 3 H]nitrobenzylthioinosine (NBMPR), which inhibits nucleoside fluxes by binding with high affinity to ...
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Characterization of Genotypic Mutations and Antiretroviral Resistance among Viremic HIV Infected Patients in a High HIV Prevalence Area: Treatment Challenge and Transmission Risk
... There have been few reports evaluating the prevalence of genotypic mutations and antiretroviral resistance among chronic HIV-infected Veterans within the United States. This retrospective cross-sectional study ...
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6 methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro
... Background: Canine distemper (CD) is a widespread infectious disease that can severely impact a variety of species in the order Carnivora, as well as non-carnivore species such as non-human primates. Despite large-scale ...
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