Nucleoside-diphosphate kinase
Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotype
... In the absence of effective vaccine against leishmaniasis, the only way to treat and control all forms of the disease is through the use of chemotherapy. Pentavalent antimo- nials are considered one of the main options ...
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Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase
... tein kinase (AMPK) binds to and phosphorylates CFTR, attenu- ating PKA-activated CFTR ...that nucleoside diphosphate kinase A (NDPK-A) interacts with both AMPK and CFTR in overlay blots of ...
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Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue
... Results: The two groups with poor prognosis (n = 4) and with better prognosis (n = 4) had been carefully chosen among 96 resected cases of pancreatic cancer during 1998 to 2007 in Tohoku University Hospital. Although ...
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Dissecting the Unique Nucleotide Specificity of Mimivirus Nucleoside Diphosphate Kinase
... virus-encoded nucleoside diphosphate kinase (NDK), an enzyme that is central to the synthesis of RNA and DNA, ubiquitous in cellular organisms, and well conserved among the three domains of ...
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Proliferation related expression of p19/nm23 nucleoside diphosphate kinase
... High level expression of the nm23-H1 gene, which encodes for a nucleoside diphosphate kinase, has been found to correlate with diminished metastasis in some tumors but not in others. We have ...
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Escherichia coli Strains (ndk) Lacking Nucleoside Diphosphate Kinase Are Powerful Mutators for Base Substitutions and Frameshifts in Mismatch-Repair-Deficient Strains
... Hamby, C. V., C. E. Mendola, L. Potla, G. Stafford and J. M. colorectal carcinoma syndrome. Cancer Res. 53: 5853–5855. Backer, 1995 Differential expression and mutation of NME Postel, E. H., S. J. Berberich, S. J. Flint ...
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SwoHp, a Nucleoside Diphosphate Kinase, Is Essential in Aspergillus nidulans
... a nucleoside diphosphate kinase ...a nucleoside triphosphate to a nucleoside diphosphate and are important in nucleotide metabolism (2, ...
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Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A
... protein kinase A (PKA) and ATP-regulated chloride ...that nucleoside diphosphate kinase B (NDPK-B, NM23-H2) forms a functional complex with ...
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Sharma, Rita (2006): Phosphorylation of chloroplast preproteins and the characterisation of nucleoside diphosphate kinase 2. Dissertation, LMU München: Fakultät für Biologie
... NM23-H2, a presumed regulator of tumor metastasis in humans, is a hexameric protein with both enzymatic (NDP kinase) and regulatory (transcriptional activation) activity. Within the sequence of this protein, ...
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Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity
... (NDP kinase activity), or (iii) a serine or threonine residue of a different protein (phosphotransferase activity) attacks the P atom of the phosphohistidine intermediate, assisted again by His221 ...NDP ...
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Syndromes associated with mitochondrial DNA depletion
... mitochondrial nucleoside diphosphate kinase, resulting in mitochondrial dNTP pool imbalance and, eventually, low levels of mtDNA in muscle ...
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CSGID solves structures and identifies phenotypes for five enzymes in Toxoplasma gondii
... putative nucleoside diphosphate kinase (TgNDK) (residues 1– 155), ribulose phosphate 3-epimerase (TgRPE) (residues 1– 230), a putative ribose 5-phosphate isomerase (TgRPI) (residues 1–259), and a ...
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The influence of HAART on the efficacy and safety of pegylated interferon and ribavirin therapy for the treatment of chronic HCV infection in HIV-positive individuals
... In Europe up to 33% of the HIv-positive patients are co-infected with hepatitis c virus (Hcv) [1, 2]. In Hcv/HIv co-infected patients liver-related disease has emerged as a leading cause of morbidity and mor- tality [3]. ...
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Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages
... of nucleoside analogues on wild-type HIV-1, there had been no previous reports on HIV resistance to nucleoside analogues in ...to nucleoside ana- logues conferred by TAMs did not significantly differ ...
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Enhancing solubility of deoxyxylulose phosphate pathway enzymes for microbial isoprenoid production
... A : Metabolites and enzymes related to the mevalonate (MVA) pathway; MVA: Mevalonate, MVAP: Mevalonate phosphate, MVAPP: Mevalonate diphosphate, IPP: Isopentenyl diphosphate, DMAPP: Dime[r] ...
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Elucidation of the secoiridoid pathway in Catharanthus roseus
... The GES gene from Valeriana officinalis (VoGES) encodes a protein which shares 37-67 % identity with GES proteins from other plant species (Table 1, Figure 1). Previous characterized GES gene from Lippia dulcis (LdGES) ...
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Synthesis of DNA and Poly(Adenosine Diphosphate Ribose) in Normal and Chronic Lymphocytic Leukemia Lymphocytes
... leukemia (CLL) and 12 normal control donors. The cells were assayed for synthesis of DNA and poly-(adenosine diphosphate ribose) (poly[ADPR]) immediately after isolation and on successive days following their ...
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Reinvestigation of cadmium diphosphate
... Bond-valence sums (Brown, 2002) were computed at the end of the refinement using the softBV applet (Adams, 2004): Cd1 (six neighbours) 1.80 v.u., Cd2 (six) 2.12 v.u., P1 (four) 4.91 v.u. and P2 (four) 4.95 v.u., and a ...
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Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy
... isopentenyl diphosphate (IPP) and dimethyl- ally diphosphate (DMAPP), two intermediates of the mevalonate pathway (MVA) that presents within the cytoplasm and mitochondria of all plant ...
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Cytosine Arabinoside Influx and Nucleoside Transport Sites in Acute Leukemia
... of nucleoside transport sites was estimated for each cell type by measuring the equilibrium binding of [ 3 H]nitrobenzylthioinosine (NBMPR), which inhibits nucleoside fluxes by binding with high affinity to ...
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