Nucleoside transporter 1 (NT1)
Persistent Hepatitis C Virus Infection Impairs Ribavirin Antiviral Activity through Clathrin-Mediated Trafficking of Equilibrative Nucleoside Transporter 1
... through nucleoside transporters, such as equilibrative nucleoside transporter 1 (ENT1), that are expressed on the plasma membrane of many cell types ...
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FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia
... a nucleoside analog that requires membrane transport proteins of the human nucleoside transporters (hNT) gene families SLC28 and SLC29 to be internalized into target ...Concentrative Nucleoside ...
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Ectopic Mineralization of Spinal Tissues in Mice Lacking Equilibrative Nucleoside Transporter 1
... Equilibrative nucleoside transporter 1 (ENT1) regulates the bi-directional transfer of hydrophilic nucleosides, such as adenosine, across the plasma ...pyrophosphatase/phosphodiesterase 1 ...
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High expression of the human equilibrative nucleoside transporter 1 gene predicts a good response to decitabine in patients with myelodysplastic syndrome
... Decitabine is administered to patients without knowl- edge of their genetic background, which may affect drug efficacy. The primary mechanism for insufficient intra- cellular concentrations of decitabine may result from ...
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A novel RNA variant of human concentrative nucleoside transporter 1 (hCNT1) that is a potential cancer biomarker
... cation transporter OCTN2 in which a 72-base- pair sequence located in the first intron of OCTN2 gene was spliced between exons 1 and 2, was retained in the endoplasmic reticulum, and did not transport ...
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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
... control, 1 hour before renal ischemia) and subsequently exposed to 30 minutes of renal ischemia, and renal function was assessed by measurement of GFR following 1 hour of reperfusion (n = ...400; 1 ...
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Gene expression of <em>hENT1</em>, <em>dCK</em>, <em>CDA</em>, <em>dCMPD </em>and <em>topoisomerase </em>IIα as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin
... equilibrative nucleoside transporter 1, deoxycytidine kinase, cytidine deaminase (CDA), deoxycytidine monophosphate deaminase (dCMPD) and topoisomerase IIα ...
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ENT1 and ENT1 mice during both normoxic and hypoxic conditions. Gene expression was
... Adenosine is important in the regulation of vascular tone and the Equilibrative Nucleoside Transporter 1 (ENT1) is a regulator of adenosine concentrations. Thus, changes in ENT1 expression and ...
134
Ormanns, Steffen (2018): Molekulare Dysregulationen und ihre Biomarker im Pankreaskarzinom. Habilitationsschrift, LMU München: Medizinische Fakultät
... Obgleich die große Mehrheit der PDAC aktivierende KRAS-Gen Mutationen aufweist, was auf eine konstitutive Aktivierung des MAPK-Signalweges schließen lässt, zeigen wir im fortgeschrittenen Pankreaskarzinom eine heterogene ...
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Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance
... equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most ...
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Impact of Y181C and/or H221Y mutation patterns of HIV 1 reverse transcriptase on phenotypic resistance to available non nucleoside and nucleoside inhibitors in China
... First-generation NNRTIs have a low genetic barrier for resistance. Only a single-nucleotide change can result in high-level resistance with little impact on the replication [10]. Moreover, mutations are stable and hardly ...
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Uptake of purines in Plasmodium falciparum infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
... The data presented in this manuscript clearly show that hypoxanthine enters P. falciparum-infected human erythrocytes overwhelmingly through a saturable, ade- nine-sensitive transport mechanism, which is compatible with ...
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Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
... In vitro, the barrier function in brain endothelial cells is promoted by astroglia cocultures. Coculture BBB models were set up with hiPSC-derived astroglia and hiPSC-derived brain endothelial cells (r-iBECs). Bar- rier ...
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Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese
... Concentrative nucleoside transporter; Ctrl: Control; F: Frequency; GWAS: Genome-wide association study; HCB: Han Chinese in Beijing; HUA: Hyperuricemia; HWE: Hardy- Weinberg equilibrium; OR: Odds ratio; P: ...
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Expression and functional activity of nucleoside transporters in human choroid plexus
... mitochondrial transporter [4], which can also transport several nucleoside reverse tran- scriptase inhibitors, including AZT, ddI and ddC ...This transporter is relatively insensitive to NBMPR and is ...
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Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002
... December 1, 2001, the Thai Government Pharmaceu- tical Organization (GPO) reduced the monthly cost of their ARV medications from 5,000 Baht (US$112) to 2,500 Baht (US$ ...
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Modified SureSelectQXT Target Enrichment Protocol for Illumina Multiplexed Sequencing of FFPE Samples
... (Pool 1), we used all library preparation product for the lower concen- trations and then we adjusted the rest of the samples to an equal concentration (Additional file 4: Table ...
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Marriages, Polygamous, Early Fertility and Development in Congo
... DOI: 10.4236/jhrss.2017.53018 197 Journal of Human Resource and Sustainability Studies Because the both men agents have the opportunity to have 1 to 4 wives, men fertility increases, which decreases his per-capita ...
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Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma
... pyrimidine nucleoside monophosphate kinase were not different between any of the leukemic cell ...of nucleoside transport sites on blasts was estimated by measuring the ...
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Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd Ameliorates hyperuricemia and acute gouty arthritis in animal model
... ICR mice were divided into 6 groups, and each group including 10 animals. They were blank, model, colchicine (1 mg/kg/day), the GPE (100, 200 and 400 mg/kg/day) groups. Drugs were intragastricly feed once daily ...
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