Nucleotide Exchange Factor
Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte intrinsic signaling to maintain skin homeostasis
... guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic ...
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New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia
... guanine nucleotide exchange factor (RhoGEF), has been studied primarily in tissue culture, where it exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates ...
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Role of the Guanine Nucleotide Exchange Factor Rom2 in Cell Wall Integrity Maintenance of Aspergillus fumigatus
... Aspergillus fumigatus is a mold and the causal agent of invasive aspergillosis, a systemic disease with high lethality. Recently, we identified and functionally characterized three stress sensors implicated in the cell ...
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The Putative Guanine Nucleotide Exchange Factor RicA Mediates Upstream Signaling for Growth and Development in Aspergillus
... guanine nucleotide exchange caused by ligand-bound (sensitized) GPCRs, causing the dissociation of the GTP-bound G ␣ subunit and the G ␥ heterodimer, which then transduce signals by interacting with ...
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Molecular Determinants of the Interaction between Coxsackievirus Protein 3A and Guanine Nucleotide Exchange Factor GBF1
... The 3A protein of coxsackievirus B3 (CVB3), a small membrane protein that forms homodimers, inhibits endoplasmic reticulum-to-Golgi complex transport. Recently, we described the underlying mechanism by showing that the ...
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A Nucleotide Exchange Factor Promotes Endoplasmic Reticulum-to-Cytosol Membrane Penetration of the Nonenveloped Virus Simian Virus 40
... that nucleotide exchange factor (NEF) Grp170 induces nucleotide exchange of BiP and releases SV40 from ...a nucleotide exchange activity essential for catalyzing the most ...
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9-24-2014 12:00 AM The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response
... observed include: mutant copper/zinc superoxide dismutase (mtSOD1) (Rosen et al., 1993), TAR DNA-binding protein of 43 kDa (TDP-43) (Neumann et al., 2006), fused in sarcoma/translocated in liposarcoma (FUS) (Kwiatkowski, ...
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Original Article Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma
... guanine nucleotide exchange factor (GEF) family, which is highly expressed in excitable tissues such as the brain, heart, and muscle ...the exchange of bound guanosine diphosphates (GDP) for ...
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Guanine Nucleotide Exchange Factor OSG-1 Confers Functional Aging via Dysregulated Rho Signaling in Caenorhabditis elegans Neurons
... ABSTRACT Rho signaling regulates a variety of biological processes, but whether it is implicated in aging remains an open question. Here we show that a guanine nucleotide exchange factor of the Dbl ...
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A Role for the Noncatalytic N Terminus in the Function of Cdc25, a Saccharomyces cerevisiae Ras-Guanine Nucleotide Exchange Factor
... The Saccharomyces cerevisiae CDC25 gene encodes a guanine nucleotide exchange factor (GEF) for Ras proteins. Its catalytic domain is highly homologous to Ras-GEFs from all eukaryotes. Even though ...
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Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
... Guanine nucleotide exchange factor H1 (GEF-H1), which couples microtubule dynamics to RhoA activation, is a microtubule-regulated exchange ...
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Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22
... guanine-nucleotide exchange factor (GEF) of Rab1 [6,7] and whose N-terminal domain exhibits adenosine monophosphorylation (AMPylation) activity toward Rab1 ...
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Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans
... The AVG axon pioneers the right axon tract of the VNC in C. elegans and is critical for the navigation of follower axons (Durbin 1987; Hutter 2003). We isolated an allele of aex-3 in an enhancer screen for AVG axon ...
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The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH
... nine nucleotide exchange factors (GEFs), which promote dissoci- ation of GDP and subsequent binding of GTP and GTPase- activating proteins (GAPs), which enhance the rate of GTP hydrolysis to GDP, while ...
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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
... Scheme S1. CRISPR/Cas9 directed mutagenesis of the hamster Eif2b2 gene at the locus encoding ISRIB contact sites on the eIF2B β subunit revealed by the structure: N162, H188 or I190. Hamster Eif2b2 exon 3 with the two ...
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Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells
... Bone marrow cells obtained from C57/BL6 mouse were maintained in RPMI1640 supplemented with 10% X63- GM cell culture supernatants as a source of granulocyte macrophage colony-stimulating factor (GM-CSF) or 50 ...
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Guanine Nucleotide Exchange Factor 7B (RopGEF7B) is involved in floral organ development in Oryza sativa
... of both osropgef7b-1 mutant (Additional file 1 : Figure S4D-F, M) and RNAi L31 plant (Additional file 1 : Figure S4J-M) were not different from those of the wild type (Add- itional file [r] ...
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Essential Role of the NH2-Terminal Region of Cdc24 Guanine Nucleotide Exchange Factor in Its Initial Polarized Localization in Saccharomyces cerevisiae
... At 120 min after release, wild-type GFP-Cdc24 localized to the site of FIG 3 Cdc24-ts proteins are defective in their initial polarized localization in the absence of Bem1.. Cells grown [r] ...
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The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase 3 production in rheumatoid arthritis synovial tissue
... otide exchange factors (GEFs), which catalyze the exchange of GDP on inactive GTPase for ...guanine nucleotide-releasing factor 1 (RasGRF) coupling to G protein- coupled receptors – achieve ...
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Guanyl Nucleotide Exchange Factor Sql2 and Ras2 Regulate Filamentous Growth in Ustilago maydis
... active b heterodimer (64). The pheromone-induced transcrip- tion, as well as the basal transcription of the a and b genes, is mediated by the HMG domain transcription factor Prf1 (30). Prf1 is presumed to be ...
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