Nucleotide Excision Repair
Posttranslational Inhibition of Ty1 Retrotransposition by Nucleotide Excision Repair/Transcription Factor TFIIH Subunits Ssl2p and Rad3p
... rtt4-1 (r egulator of Ty t ransposition) is a cellular mutation that permits a high level of spontaneous Ty1 retrotransposition in Saccharomyces cerevisiae. The RTT4 gene is allelic with SSL2 (RAD25), which encodes a DNA ...
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Catalytic sites for 3'- and 5' incision of Escherichia coli nucleotide excision repair are both located in UvrC.
... eukaryotic nucleotide excision repair system, the 3 ⬘ and 5 ⬘ incisions are made by different proteins (20, ...bacterial repair system the two incisions were induced by two different proteins ...
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Mechanism and regulation of DNA damage recognition in nucleotide excision repair
... Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the ...the repair reaction by recognizing sites of DNA ...
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Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... Nucleotide excision repair (NER) is a versatile DNA repair pathway that removes a broad spectrum of DNA lesions that tend to distort the double helix, and is well known for its role in the ...
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The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway
... superfamily 2 helicase and the founding member of a family of DNA helicases with iron–sulphur cluster domains. As a component of transcription factor II H (TFIIH), XPD is involved in DNA unwinding during ...
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Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents
... Effective treatment of cancers usually requires the use of genotoxic chemotherapy. In most cases, multiple drugs are used, as resistance to single agents occurs almost universally. However, this causes many side effects ...
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The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition
... DNA repair pathways, limits L1 retrotransposition (Gasior et ...damage repair, notably in the removal of the DNA flap structures during single-strand annealing (SSA) repair of DSBs (Sargent et ...the ...
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Genetic variants in the nucleotide excision repair pathway genes and gastric cancer susceptibility in a southern Chinese population
... Methods: Here, we systematically analyzed the associations between nine polymorphisms in four key genes (XPA, ERCC1, ERCC2, and ERCC4) in the nucleotide excision repair pathway and gastric cancer ...
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The Mechanism of Nucleotide Excision Repair-Mediated UV-Induced Mutagenesis in Nonproliferating Cells
... functional nucleotide excision repair (NER), but the molecular mechanism of this unique type of mutagenesis has not been further ...mismatch repair nor interstrand crosslink repair ...
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Nucleotide excision repair deficiency in melanoma in response to UVA
... damage. Repair of UVA-induced DNA damage is thought to occur primarily through the Nucleotide Excision Repair (NER) pathway, which recognises and repairs damage either coupled to transcription ...
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Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes
... mismatch repair proteins MutS and MutL correct replication errors and prevent recombination between homeologous (nonidentical) ...the nucleotide excision repair proteins Rad1p and Rad10p were ...
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Base flipping in nucleotide excision repair
... several repair mechanisms have evolved to avoid these ...mechanisms, nucleotide excision repair (NER) 2 is characterized by the unique feature that it is able to recognize and repair a ...
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Nucleotide excision repair pathway gene polymorphisms are linked to breast cancer risk in a Chinese population
... including nucleotide excision repair (NER), mismatch repair (MMR), bases excision repair (BER), transcription-coupled repair (TCR), and double-strand DNA break ...
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Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts
... the nucleotide excision repair (NER) pathway ...genomic repair (GGR), which removes lesions genome-wide, and transcription-coupled repair (TCR), which removes lesions specifically from ...
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Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing
... Nucleotide excision repair (NER) is a multistep DNA repair process in which a broad spectrum of DNA lesions are re- moved in two stages - one acting genome-wide (GG-NER) and the other on ...
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Nucleotide excision repair : a multi-step mechanism required to maintain genome integrity
... multiple repair pathways and various checkpoint signal transduction and effectors systems (hoeijmakers, ...dNa repair. several different dNa repair pathways have been identified which are activated ...
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Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli
... first nucleotide after lacI termination codon through the coding sequence for ami- noacid 65 of the ...last nucleotide of the 54-nucleotide deletion of the polylinker region; (2) first and last ...
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Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein
... or cloned rat embryo fibroblasts (CREF) were transfected with 4 mg of a UV- damaged or a control nonirradiated pMSV-Luc plasmid together with 4 mg of pSV2-CAT (to control for transfection efficiency). Certain plates also ...
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A combined structural and biochemical approach reveals translocation and stalling of UvrB on the DNA lesion as a mechanism of damage verification in bacterial nucleotide excision repair
... the nucleotide on the 3 ′ side of the modi fi ed residue will reside near Tyr298 of Tm-UvrB and, after base rotation around the glycosidic bond, near Ile112 ...
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Specificity of the yeast rev3 delta antimutator and REV3 dependency of the mutator resulting from a defect (rad1 delta) in nucleotide excision repair.
... RADl is required for the incision step of excision repair (FRIEDBERG 1988) and its inactivation specifically increases the rates of spontaneous single base-pair substitution[r] ...
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