nude-mice
Characteristics of Viruses Derived from Nude Mice with Persistent Measles Virus Infection
... the nude mouse brain in this study, the viral titers of the persistent viruses in the superna- tant of cell cultures were approximately 100-fold lower than those of the Edmonston strain before inoculation, and the ...
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TRIP Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors
... soft agar. We also demonstrated that overexpression of TRIP-Br2 induced tumors in athymic nude mice (nu/nu). Transformed cellular phenotypes were associated with dysregulation of the E2F/DP-transcriptional ...
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Experimental infection of Balb/c nude mice with Hepatitis E virus
... HEV antigens were observed by indirect immunofluores- cence in liver, spleen, kidney, jejunum, ileum and colon in the inoculated group on days 4 and 7, and in one of member of contact-exposed group on day 7 using appro- ...
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Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice
... in nude mice after in vitro culture, however, we examined whether or not a shorter in vitro steroid exposure could be used to regulate en- dometrial MMP ...
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Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90 Y-labeled anti-α
... To assess the toxicity, body weight of each mouse was measured every 3-4 days. At 27 days after the first administration, all mice were euthanized. Their blood samples were collected through cardiac puncture, and ...
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DR5 mAb-conjugated, DTIC-loaded immuno-nanoparticles effectively and specifically kill malignant melanoma cells in vivo
... We combined chemo- and immunotherapies by constructing dual therapeutic function immuno-nanoparticles (NPs) consisting of death receptor 5 monoclonal antibody (DR5 mAb)-conjugated nanoparticles loaded with dacarbazine ...
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Original Article Homing of SPIO-MSCs to liver metastasis in nude mice
... Abstract: Objective: This study aims to investigate the feasibility of delivering SPIO (full name?) to tumor metastases through homing of mesenchymal stem cells (MSCs). Methods: The effect on MSCs activity by various ...
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Original Article Effects of lentiviral-mediated Wnt5a overexpression on biological functions of hepatoma cells and expression of Gli1 transcription factor
... The nude mouse tumorigenesis experiment indirectly reflected the effect of Wnt5a on ...the nude mice infected with Wnt5a-overexpressing cells was significantly lower than that in the control group, ...
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Beta protein 1 homeoprotein induces cell growth and estrogen- independent tumorigenesis by binding to the estrogen receptor in breast cancer
... Beta Protein 1(BP1), an isoform of DLX4, belongs to the homeobox family of genes, master regulatory genes implicated in early development and cell differentiation that are frequently deregulated in cancer [1, 2]. ...
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Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice
... Background: Advanced hepatocellular carcinoma (HCC) patients undergo significant tumor growth and metastasis. Here, we investigated bufalin for treating HCC, which exhibits anti-tumor activities in many tumor cell lines. ...
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The Chinese medicine JC 001 enhances the chemosensitivity of Lewis lung tumors to cisplatin by modulating the immune response
... BALB/c mice are T-cell deficient, they retain functional innate immun- ...immunocompetent mice compared with the 61% reduction of tumor mass in BALB/c nude mice sug- gests that approximately ...
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Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo
... when nude mice and BALB/c mice were pre-injected with nanogram levels of a synthetic Zfra1–31 or truncated Zfra4–10 peptide via tail veins, these mice became resistant to the growth, ...
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Original Article Small interfering RNA survivin and GRIM-19 co-expression salmonella plasmid inhibited the growth of laryngeal cancer cells in vitro and in vivo
... the nude mice were killed, and the tumor, heart, liver, lung, kidney and spleen were collection for the detection of bacterial colo- ...in nude mice, in the psi-survivin group, p-GRIM-19 group ...
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Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway
... Male nude mice around 4~8 weeks old and weights from 20 ~ 25 g were applied for orthotopic and subcutaneous xenograft nude mice ...and nude mice were housed in a standard ...
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Experimental Therapeutic Trial of an Antibody against the Cell Adhesion Molecule Gicerin for Lymphomas Using a Murine Cell Line
... of nude mice was measured every day after injection with anti-gicerin antibody or pre-immune IgG (control) in- ...in mice receiving control IgG in- ...in mice implanted with YAC1 cells (Figure ...
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The herbal compound Songyou Yin (SYY) inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells
... a nude mouse model with liver fibrosis bearing orthotopic xenograft was established and we found that SYY could reduce associated fibrosis, inhibit tumor growth and improve ...in nude mice models ...
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Stromelysin 3 expression promotes tumor take in nude mice
... Tumors that are obtained by S.C. injection of malignant cells into nude mice should be regarded as a model for meta- static implantation rather than for primary tumor development (45). Indeed, S.C. injected ...
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Vaccinia Virus Vectors with an Inactivated Gamma Interferon Receptor Homolog Gene (B8R) Are Attenuated In Vivo without a Concomitant Reduction in Immunogenicity
... Knockout mice with an inactivated IFN-␥ receptor gene were found to be more susceptible to infection with VV or herpesvirus than were mice with an inactivated IFN-␥ gene (11), although one would assume that ...
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Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models Martina D’Aronzo 1,* Manlio Vinciguerra 1,2,3,* Tommaso Mazza 4Concetta Panebianco 1, Chiara Saracino1 , Stephen P. Pereira 2, Paolo Graziano5 and Valerio Pazienza 1
... the nude mice allocated in the four treatment ...PC mice subjected to combined fasting and gemcitabine treatment as compared to control ...(83%) mice subjected to 24h of complete fasting prior ...
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Autonomy of growth and of iodine metabolism in hyperthyroid feline goiters transplanted onto nude mice
... Hyperthyroidism caused by nodular goiters is a common disease of aging cats. Growth and iodine metabolism were studied by autoradiography in normal and hyperfunctioning thyroid tissue obtained from cats injected with ...
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