O-glycosylation
A conserved major facilitator superfamily member orchestrates a subset of O glycosylation to aid macrophage tissue invasion
... of O-glycosylation is particularly relevant for cancer (Fu et ...truncated O-glycans called T and Tn antigen are not normally found on most mature human cells (Cao et ...T O-glycan structure ...
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Role of O-Glycosylation and Expression of CD43 and CD45 on the Surfaces of Effector T Cells in Human T Cell Leukemia Virus Type 1 Cell-to-Cell Infection
... of O-glycosylation in Jurkat-Cosmc cells enhanced the surface expression of CD43 3 to 4 times and slightly lowered the level of CD45 expression compared with that in control Jurkat ...and ...
12
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension
... Gene expression was assessed by quantitative polymerase chain reaction (qPCR) under normoxia, hypoxia and Dfx exposure. This included a group of genes associated with stem cells (NANOG, LIN28A, POU5F1, KLF9, KLF4, SOX2); ...
20
<p>Cosmc Disruption-Mediated Aberrant O-glycosylation Suppresses Breast Cancer Cell Growth via Impairment of CD44</p>
... The O-glycosylation process is normally initiated by the addition of N-acetyl galactosamine (GalNAc) to a serine or threonine residue in proteins and is branched by other sugars to produce more complex ...
12
Transient co-expression with three O-glycosylation enzymes allows production of GalNAc-O-glycosylated Granulocyte-Colony Stimulating Factor in N. benthamiana
... mucin-type O-gly- cosylated. Instead, the O-glycosylation Thr site used in mammalian cells was mannose O-glycosylated ...protein, glycosylation was apparently absent ...where ...
14
IgA N and O glycosylation profiling reveals no association with the pregnancy related improvement in rheumatoid arthritis
... and O-glycosylation traits of patients with RA in the non- pregnant state, multivariable linear regression analysis was performed on the samples obtained at 26 weeks ...
8
A Knowledge Based System for Display and Prediction of O Glycosylation Network Behaviour in Response to Enzyme Knockouts
... of glycosylation which have now appeared, most have considered N-glycosylation rather than O-glycosylation ...of O-glycosylation ...of O-glycan biosynthesis that was used ...
24
Claudin 1 required for HCV virus entry has high potential for phosphorylation and O glycosylation
... and O- b -GlcNAc modification is believed to be functional switch, but it is very difficult to monitor these functional and vibrant changes in ...possible O-glycosylation ...for O-b-GlcNAc and ...
8
O glycosylation of glycoprotein G of human respiratory syncytial virus is specified within the divergent ectodomain.
... The HN and HN19 proteins were each reduced in mass by approximately 8 kDa when 4007 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest cDNAs encoding the G glycoprotein of[r] ...
6
N-acetylgalactosaminyltransferase activity involved in O-glycosylation of herpes simplex virus type 1 glycoproteins.
... To determine the nature of the linkage of GalNAc added via GalNAc transferase to the immature forms of HSV glycoproteins, we subjected [14C]GaINAc-labeled glycoproteins to a mild alkalin[r] ...
5
Characterisation of the Streptomyces coelicolor glycoproteome reveals glycoproteins important for cell wall biogenesis
... protein O-glycosylation in prokaryotes is poorly understood due to our limited knowledge of the extent of their glycopro- ...protein O-mannosyl transferase (Pmt)-mediated protein ...
13
A novel O linked glycan modulates Campylobacter jejuni major outer membrane protein mediated adhesion to human histo blood group antigens and chicken colonization
... Although Gram-negative bacterial porins show considerable diversity in their primary sequences, they are remarkably similar in their secondary and tertiary structure, in which beta strands combine to form a ...
15
O -mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer
... Protein O-mannosylation is a posttranslational process initiated at the ER by the covalent attachment of mannose structures to serine (Ser) or threonine (Thr) amino acids of secretory and/or membrane proteins, ...
16
Logic minimization and rule extraction for identification of functional sites in molecular sequences
... the O-glycosylation problem, there are several major differ- ences in the approaches, mainly that in [50] there is no effort to extract information from the data, ...T O-glycosylated sites, which ...
21
Synthesis of Vildagliptin β O Glucuronide
... O-glycosylation methodologies have been well docu- mented [4,5]. Reactivity of the glycosyl donor can be tuned by putting on a different leaving group (X) to meet the needs for O-glycosylation ...
5
Rapid and sensitive methods for the analysis and identification of O-glycans from glycoproteins
... its glycosylation. There are two previously reported N-glycosylation sites on APP but the authors focused on O- glycosylation plus the identification of their attachment sites: for the first ...
197
Isolation and elucidation of some chemical constituents of Lavandula officinalis
... The dried powered leaves of L. officinalis (500g) was extracted by shaking with 80 % aqueous methanol (3 x 1.5 liter) for three days at room temperature. The crude methanol extract was filtered and concentrated using ...
8
Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment
... formic acid in water and (B) 0.1% formic acid in acetonitrile. Following a 4-μL injection, peptides were trapped for 3 minutes on a 5 μm Symmetry C 18 180 μm I.D. × 20 mm column at 5 μL/min in 99.9% A. The analytical ...
22
Synthesis of glycoconjugates affecting cell adhesion
... use o f a donor with a participating, acyl-type group at ...donors^^’. O f these, thioglycosides are relatively cheap to prepare and have excellent stability to protective group m ...during ...
170
Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance
... important parameter for the efficacy of glycan-reactive bnAbs. This is an important consideration for vaccine design, since any elicited bnAb response will likely require a degree of plasticity in glycan recognition in ...
8