O-linked N-acetylglucosamine
Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells.
... The miR-483-3p is upregulated in several tumors, including liver tumors, where it inhibits TP53-dependent apoptosis by targeting the pro-apoptotic gene BBC3/PUMA. The transcriptional regulation of the miR-483-3p could be ...
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Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus
... into N- and C-ter- minal subunits that remain stably associated (10, ...enzyme O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) (12–14), an essential glycosyltransferase ...
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O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes
... O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) increases O-GlcNAc modification (O-GlcNAcylation), and transcriptional co-regulator host cell factor 1 (HCF-1) is ...
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Two O-Linked N-Acetylglucosamine Transferase Genes of Arabidopsis thaliana L. Heynh. Have Overlapping Functions Necessary for Gamete and Seed Development
... animal O -linked N -acetylglucosamine transferases (OGTs; ski 1993; Jacobsen et ...transfer N-acetylglucosamine (GlcNAc) residues from signaling has come from the analysis of ...
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O linked N acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast like synoviocytes stimulated by tumor necrosis factor α and mice with collagen induced arthritis
... or O-GlcNAcylation of p65 and the aggravated severity of arthritis as follows: (i) upon initiation of RA, hyperplasia of the synovium may create localized hypoxia; (ii) in turn there might be a status of ...
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A structural polypeptide of the baculovirus Autographa californica nuclear polyhedrosis virus contains O-linked N-acetylglucosamine.
... We demonstrated that a 41K OV structural protein gp4l contains one or more 0 glycosidically linked GlcNAc residues and probably corresponds to a 42K OV glycoprotein identified by Stiles [r] ...
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Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4
... of O-linked N-acetylglucosamine ( O -GlcNAc). O - GlcNAc is linked to serine or threonine residues in pro- teins through a reaction catalyzed by ...
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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
... increases O- linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of hyperglycemia and the hexosamine ...
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A Poly N Acetylglucosamine−Shiga Toxin Broad Spectrum Conjugate Vaccine for Shiga Toxin Producing Escherichia coli
... to O-antigens, poly-N-acetylglucosamine (PNAG), a polymer of -(1⫺6)-linked N-acetylglucosamine units, is a widely conserved carbohydrate that has been detected on the sur- face ...
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Unique Microbial Catabolic Pathway for the Human Core N Glycan Constituent Fucosyl α 1,6 N Acetylglucosamine Asparagine
... through O-glycosidic or N-glycosidic bonds (7). O-Glycans are linked to a serine or threonine residue via an N-acetylgalactosamine, which is elongated by additional sugars ...(8). ...
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DYSREGULATION OF O-LINKED β-N-ACETYLGLUCOSAMINE (O-GLCNAC) CYCLING SUPPORTS TUMORIGENICITY OF CANCERS OF THE FEMALE REPRODUCTIVE TRACT, Nicole Jaskiewicz
... (Figure 4), despite the observation that K18 and β-actin expression were both diminished. Others have observed that α -tubulin and β -actin expression in colon cancer cells are unaffected by inhibition of OGT, yet the ...
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Simultaneous analyses of N-linked and O-linked glycans of ovarian cancer cells using solid-phase chemoenzymatic method
... labeled O-glycans were dissolved in 1% acetic ...labeled O-glycans were purified using an SPE C18 cartridge, which was pre- conditioned with 1 mL 100% acetonitrile (2×) and 1 mL water ...purified ...
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Bis(3 aminopyrazine 2 carboxylato κ2N1,O)diaquanickel(II) dihydrate
... In continuation of our search to enrich the variety of such kinds of hybrid compounds and to investigate the influence of hydrogen bonds on the structural features (Bouacida et al., 2007, 2009), we report here the ...
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Bis(μ N nitroso N phenylhydroxylaminato) κ3O,O′:O′;κ3O′:O,O′ bis[(N nitroso N phenylhydroxylaminato κ2O,O′)lead(II)]
... atoms; two of the four nitroso O atoms are also involved in bridging. The geometry of both five-coordinate Pb II atoms is distorted - octahedral; if another two longer intermolecular Pb O interactions [at ...
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Crystal structures of the Schiff base derivatives (E) N′ [(1H indol 3 yl)methylidene]isonicotinohydrazide ethanol monosolvate and (E) N methyl 2 [1 (2 oxo 2H chromen 3 yl)ethylidene]hydrazinecarbothioamide
... are linked by O— H O, N—H O and N—H N hydrogen bonds, forming a tape structure running along the b-axis ...weakly linked via a C—H N ...are linked via ...
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Aqua(N,N′ disalicylideneethylenediamino N,N′,O,O′)(4,5 imidazoledicarboxylato O)manganese(III) monohydrate
... The imidazole N atom of histidine has been described as a functional group (Wieghardt, 1989) in the oxygen-evolving complex (EOC) of photosystem II (PS II). 4,5-Imidazoledi- carboxylate was suggested as a bridging ...
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Covalent Modifications of the Ebola Virus Glycoprotein
... peptide N-glycosi- dase F from Chryseobacterium meningosepticum (PNGase F), which removes N-linked glycosylation, and additionally with sialidase A and endo-O-glycosidase, ...
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Crystal structures of N (pyridin 2 ylmethyl)pyrazine 2 carboxamide (monoclinic polymorph) and N (pyridin 4 ylmethyl)pyrazine 2 carboxamide1
... are linked by N—H N and C—H N hydrogen bonds to form chains propagating along [010], as shown in Table 2 and ...are linked via C—H O hydrogen bonds, forming sheets lying parallel ...
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N,N Dibenzyl O,O′ dimethyl thiophosphate
... The structure determination of the title compound (Fig. 1) was performed as a part of a project on the synthesis of a new phosphoramidothioate (Sabbaghi et al. , 2012). The P═S (1.9299 (6) Å), P—O (1.5796 (12) and ...
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Crystal structure of 7′ (4 chlorophenyl) 2′′ (4 methoxyphenyl) 7′,7a',7′′,8′′ tetrahydro 1′H,3′H,5′′H dispiro[indoline 3,5′ pyrrolo[1,2 c]thiazole 6′,6′′ quinoline] 2,5′′ dione and an unknown solvent
... an N—H N hydrogen bond and a series of C—H O hydrogen bonds, forming layers lying parallel to the (101) ...are linked by C—H interactions and offset – interactions [intercentroid distance = ...
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