Obese Zucker rats
Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats
... in obese Zucker rats is acquired and not inherited [14] and could be ameliorated by inhibition of reactive oxygen species production by tem- pol and insulin sensitization by rosiglitazone ...of ...
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Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
... from obese rats increased two- to threefold compared with lean rats (Table ...in obese rats ...of obese rats resulted in a 50% decrease in the number of large adipocytes ...
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Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese Zucker rats
... though obese Zucker rats had lower heart rate and weight, and higher systolic and pulse pressure than lean rats, these measures were unaffected by diet ...that rats consuming ...
10
Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle
... to obese Zucker rats counteracts the obesity-induced muscle fiber transition from type I to type II and, thereby, improves fatty acid utilization in skeletal ...the rats related to 156 to 216 ...
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Feeding Soy with Probiotic Attenuates Obesity Related Metabolic Syndrome Traits in Obese Zucker Rats
... The present study was conducted to evaluate the single and combinational effect of soybean and B. longum against obesity induced traits associated with metabolic syndrome in Zucker rats. A cluster of ...
10
Pulmonary arterial dysfunction in insulin resistant obese Zucker rats
... male obese Zucker rats (fa/fa) and their littermates, lean Zucker rats (fa/-) (17- 18 weeks old) were weighed and sacrificed by cervical dislocation and ...
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Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats
... to obese Zucker rats is able to improve the carnitine status of obese Zucker rats through PPAR- stimulated expression of genes involved in carnitine uptake and ...to obese ...
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Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats
... The incorporation of dietary n3PUFA had no effect on glucose homeostasis in the polygenic OZR rat. However, previous studies have shown improved insulin sensitivity with increased dietary n3PUFA intake in obese ...
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Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
... the obese Zucker rats are ...the obese Zucker rats also contribute to the decline in PI 3-kinase ...the obese rats, compared with lean ...
12
The interleukin-6 and noradrenaline mediated inflammation-stress feedback mechanism is dysregulated in metabolic syndrome: Effect of exercise
... the obese Zucker rats, lends support to a recent suggestion that IL-6 plays a role as a systemic regulator of body weight and lipid metabolism ...the obese Zucker rats: Training- ...
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Receptor mediated regional sympathetic nerve activation by leptin
... in obese Zucker rats and humans, respectively (24, ...in obese Zucker rats, leptin appears unlikely to un- derlie the renal sympathoactivation observed in these ...in ...
10
Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress.
... The obese Zucker rat is an established model of T2D mellitus and displays the hallmark biochemical characteris- tics of the disease including hyperinsulinemia, hypergly- cemia and hyperlipidemia, in ...
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Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
... ZDF rats are inbred from a colony of obese Zucker rats with a hyperglycemic ...control rats due to pancreatic beta cell failure and renal injury develops ...
8
Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice
... Female obese Zucker rats, on the other hand, showed high severity of the disease but less effects of MCT-induced ...MCT Zucker rats in comparison to their lean con- ...in obese ...
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Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist
... and obese Zucker rats were implanted subcutaneously with osmotic mini-pumps, infusing either saline or CL (1 mg/kg body weight/day) for 4 ...and obese rats increased by 55% and 96% per ...
8
Obesity promotes 7,12 dimethylbenz(a)anthracene induced mammary tumor development in female zucker rats
... to Zucker rats as a model. The Zucker rat (fa/fa) is the best known, most widely used rat model of genetic ...the Zucker rat is inherited as an autosomal-recessive trait caused by a mutation ...
7
Modeling of free fatty acid dynamics : insulin and nicotinic acid resistance under acute and chronic treatments
... In this study, we sought to further develop the concepts used in previous analyses to develop a more general NiAc- FFA interaction model—applicable to a large set of dosing regimens and NiAc exposure durations. The model ...
21
Blueberry as a source of bioactive compounds for the treatment of obesity, type 2 diabetes and chronic inflammation
... Supplementation of 2% freeze-dried blueberry powder for 13 weeks in Obese Zucker rats have 385.. demonstrated significant reductions in glucose, fasting insulin and insulin resistance, [r] ...
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Differential regulation of adipose tissue glucose transporters in genetic obesity (fatty rat) Selective increase in the adipose cell/muscle glucose transporter (GLUT 4) expression
... young obese Zucker rats exhibit a hyperresponsive insulin-mediated glucose transport, together with a marked increase in cytochalasin B binding as compared with lean rat ...in rats aged 16 or ...
6
Lovastatin inhibits proliferation of rat mesangial cells
... We chose to study mesangial cells of obese Zucker rats because previous experiments demonstrated a significant action of lovastatin in vivo to reduce mesangial cellularity and matrix exp[r] ...
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