oestrogen receptor
The Role of Oestrogen Receptor Beta (ERβ) in the Aetiology and Treatment of Type 2 Diabetes Mellitus
... of oestrogen receptors (ERs) and its significant role in regulating the expression of these receptors is well established ...the oestrogen receptor ...the receptor to interact with ...
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Phytoestrogen (+) pinoresinol exerts antitumor activity in breast cancer cells with different oestrogen receptor statuses
... the oestrogen receptor status is a key factor to consider in breast cancer ...in oestrogen receptor-positive breast cancer [17, ...different oestrogen and progesterone receptor ...
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In silico discovery and validation of potent small molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α
... We evaluated the ERα transcriptional inhibitory potential of VPC-16225 and VPC-16230 by measuring the mRNA expression levels of the oestrogen-responsive genes pS2, cathepsin D (CTSD) and CDC2 [49,50]. MCF7 cells ...
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Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen Receptor Positive Breast Cancer Cells
... Cases of hormone-dependent carcinoma are significantly lower in regions with a traditional diet high in phy- toestrogens than in regions with minor intake. The outstanding constituents in the group of phytoestrogens are ...
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Oestrogen receptor β (ERβ) regulates osteogenic differentiation of human dental pulp cells
... press oestrogen receptor (ER) isoforms ER , ER 1 and ER 2, as well as a 7-transmembrane G protein-coupled receptor, GPR30, that mediates rapid oestrogen signalling ...main receptor ...
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Recruitment of insulin receptor substrate 1 by erbB3 impacts on IGF IR signalling in oestrogen receptor positive breast cancer cells
... both oestrogen-responsive and non-oestrogen- responsive breast cancer cell lines contain SP, exhibit multidrug resistance and express elevated levels of ABCG2, the non-oestrogen-responsive more ...
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Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling
... Figure 4 Systemic oestrogen signalling is mediated by EGFR and Notch. (A) Representative Western blot showing expression of cleaved (active) Notch1 (N1-ICD) following culture ± 1 nM 17 b -estradiol ± 10 μ M GSI. ...
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Understanding the mechanisms of aromatase inhibitor resistance
... with oestrogen receptor (ER)-positive advanced breast cancer reported that patients who received the combination therapy experienced signifi - cantly longer progression-free survival (PFS) and an improvement ...
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Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers
... Approximately 70% of patients have breast cancers that are oestrogen receptor alpha positive (ER+) and are therefore candidates for endocrine treatment. Many of these patients relapse in the years during or ...
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Hypersensitive K303R oestrogen receptor α variant not found in invasive carcinomas
... Most breast cancers overexpress oestrogen receptor-α (ER-α), and this molecule is the major target of the anti- estrogens, such as tamoxifen, used to treat the disease. Not all patients respond to ...
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Oestrogen receptor negative breast cancers exhibit high cytokine content
... inversely correlated to oestrogen receptor and progesterone receptor status. Most cytokines were not correlated with age at cancer diagnosis, tumour size, histological type, or lymph node status. ...
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Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway
... both oestrogen-induced and EGF-induced ...either oestrogen-modu- lated or EGF-modulated genes is limited, making it highly unlikely that the BCAR genes use major parts of these sig- nalling ...to ...
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Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1
... globulin receptor can mediate oestrogen-induced activation of ade- nylate cyclase via the Gs protein ...II receptor AT1 is another attractive oestrogen-signalling GPCR ...coupled ...
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Oestrogen receptor negative early operable primary breast cancer in older women—biological characteristics and long term clinical outcome
... in oestrogen receptor (ER) positivity, where over 80% of older (70 years) women tend to develop ER-positive tumours [3], which are also considered as a less aggressive ...
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Male breast carcinoma: increased awareness needed
... Th e discovery that oestrogens are produced locally in breast tissues, by aromatisation of other sex steroid hormones [36], led to concerted eff orts to exploit this pathway as a potential therapeutic target. Unlike ...
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PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer
... Given the difference in the estimates of the effects of hor- mone therapy from the ECRIC dataset compared to pub- lished clinical trial data, we also fit models (constrained models) with the relative hazard of hormone ...
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... the oestrogen- influenced target organs of animals, and also in human breast ...an oestrogen receptor (ER) was ...upon oestrogen and/or progesterone for growth, and that this effect is ...
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Distinct expression patterns of ER alpha and ER beta in normal human mammary gland
... Using serial sections, the expression and distribution of ERα and ERβ were analysed and compared. In accordance with previous reports, ERα was restricted to the cell nuclei of lumi- nal epithelial cells lining ducts and ...
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Oestrogen receptor alpha in pulmonary hypertension
... G-protein-coupled receptor, GPER, which mediates rapid, non-genomic effects of ...of oestrogen in the human vasculature. Figure 3 Estrogen-receptor expression is reduced in female SERT + mouse ...
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Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas
... Estrogen receptor; GWAS: Genome- wide association study; HCRCOH: Hereditary cancer registry of City of Hope; IRB: Institutional review board; LD: Linkage disequilibrium; MAF: Minor allele frequency; Mb: Megabases; ...
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