Oligoadenylate synthetase
Extracellular 2′-5′ Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity
... The 2 ⴕ -5 ⴕ oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely ...
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Activation of the Interferon-Inducible 2′-5′-Oligoadenylate Synthetase Gene by Hepatitis C Virus Core Protein
... -oligoadenylate synthetase (2 ⴕ -5 ⴕ -OAS) gene promoter in a dose-dependent man- ner in different human hepatocyte cell lines (PH5CH8, HepG2, and ...
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A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines
... Results: Here we propose a modified coupled spectrophotometric assay to detect 2-5 oligoadenylate synthetase (OAS) enzyme activity in prostate cell lines as a model system. The OAS enzyme from prostate ...
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Original Article Low expression of 2’-5’ oligoadenylate synthetase 1 predicted poor prognosis in colorectal cancer
... Abstract: 2’-5’ oligoadenylate synthetase 1 (OAS1) is an IFN inducible enzyme and can activate RNaseL, degrade cellular RNA and inhibit protein synthesis. Except anti-virus infection, OAS1 is involved in ...
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Rotavirus Controls Activation of the 2′-5′-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms
... The innate immune response is the first line of defense of the host cell against a viral infection. In turn, viruses have evolved a wide variety of strategies to hide from, and to directly antagonize, the host innate ...
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The 2′-5′-Oligoadenylate Synthetase 3 Enzyme Potently Synthesizes the 2′-5′-Oligoadenylates Required for RNase L Activation
... The members of the oligoadenylate synthetase (OAS) family of proteins are antiviral restriction factors that target a wide range of RNA and DNA viruses. They function as intracellular double-stranded RNA ...
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Inhibition of 2′,5′-Oligoadenylate Synthetase Expression and Function by the Human Cytomegalovirus ORF94 Gene Product
... -oligoadenylate synthetase (OAS)/RNase L path- way is an important innate immune response which acts to block viral ...-linked oligoadenylate products (2-5A) (2, 8), which activate latent ...
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Clinical significance of serum 2,5-oligoadenylate synthetase and soluble interleukin-2 receptor in hemophiliacs positive and negative for human immunodeficiency virus type 1.
... We measured serum 2,5-oligoadenylate synthetase (2,5-AS) levels and soluble interleukin-2 receptor (sIL-2R) levels in human immune deficiency virus type 1 (HIV-1)-positive and HIV-1-nega[r] ...
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Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway
... ABSTRACT Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which poses a serious threat to the global pig industry. Interferons (IFNs) and IFN-stimulated genes (ISGs) play a key ...
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Cell-Type-Specific Activation of the Oligoadenylate Synthetase–RNase L Pathway by a Murine Coronavirus
... Previous studies have demonstrated that the murine coronavirus mouse hepatitis virus (MHV) nonstructural protein 2 (ns2) is a 2=,5=-phosphodiesterase that inhibits activation of the interferon-induced ...
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2′-5′-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1
... (10). Oligoadenylate synthetases (OAS) are a family of ISGs character- ized by their ability to synthesize 2=-5=-oligoadenylate (2-5A), which induces RNA degradation by activating RNase L (11, ...Human ...
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Immune interferon inhibits proliferation and induces 2' 5' oligoadenylate synthetase gene expression in human vascular smooth muscle cells
... stimulated with the well-defined mitogens IL 1 (from 15.3 +/- 0.7 to 6.2 +/- 0.7 dpm X 10(- 3)/24 h) or platelet-derived growth factor (PDGF) (from 18.5 +/- 1.0 to 7.3 +/- 0.7 dpm X 10(- 3)/24 h). Kinetic and nuclear ...
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The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is one of the few oncogenic human viruses known to date. Its large genome encodes more than 85 proteins and includes both unique viral proteins as well as proteins conserved ...
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2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells.
... To elucidate the mechanism leading to this IFN sensitivity, the expression of the 2'-5'-oligoadenylate synthetase 2-5A synthetase gene, the presence of the 2-5A synthetase protein, and t[r] ...
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Injection of mice with antibody to mouse interferon alpha/beta decreases the level of 2'-5' oligoadenylate synthetase in peritoneal macrophages.
... TOVEY,' AND MARIE-THERESE MAUNOURY' Institut de Recherches Scientifiques le Cancer, 94802 Villejuif, France,' and Department of Virology, Istituto Superiore di Sanita, 00161 Rome, Italy2[r] ...
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Activation of 2′ 5′ oligoadenylate synthetase by stem loops at the 5′ end of the West Nile virus genome
... unusual oligoadenylate chains [29-59 (A)] where the 29 carbon of ribose sugar of an adenosine mono-phosphate is linked to the 59 carbon of the next ...These oligoadenylate chains bind to and activate the ...
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Inhibition of Cellular 2′-5′ Oligoadenylate Synthetase by the Herpes Simplex Virus Type 1 Us11 Protein
... OAS lack a canonical dsRNA-binding motif but recognize dsRNA through a positively charged groove in the molecule (17). Although the precise function of each isoform is not completely understood, each displays a ...
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Protein binding to the interferon response enhancer correlates with interferon induction of 2'-5'-oligoadenylate synthetase in normal and interferon-resistant Friend cells.
... Conversely, the presence of only one specific IRS complex Fg correlates with the transcription of the 2-5A synthetase gene and the appearance of the corresponding mRNA and proteins after[r] ...
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Induction and measurement of 2',5' oligoadenylate synthetase in Madin Darby bovine kidney cells and in cattle
... We have, therefore, examined 2',5'-oligoA synthetase activity in Madin-Darby bovine kidney cells and in PBML of cattle to test its potential value as an indicator of viral infection or r[r] ...
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Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
... JOURNAL OF VIROLOGY, Dec 2007, p 12720–12729 0022 538X/07/$08 00⫹0 doi 10 1128/JVI 01471 07 Copyright © 2007, American Society for Microbiology All Rights Reserved Vol 81, No 23 MINIREVIEW Viral Encou[.] ...
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