Once weekly
Comparison of different dosing regimens (once weekly vs twice weekly, and once weekly vs once every two weeks) with epoetin delta in patients with chronic kidney disease: a randomized controlled trial
... twice weekly and once weekly dosing of epoetin delta in previously naïve patients (assessed by haemoglobin at Week 24); 2) to demonstrate non-inferiority between once weekly and ...
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Once-weekly prophylactic dosing of recombinant factor IX improves adherence in hemophilia B
... of once-weekly ...IU/kg once-weekly prophylaxis with nonacog alfa, and this prophylaxis regimen was found to be associated with lower annual bleeding rate compared with on-demand treatment in ...
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A randomized, placebo-controlled clinical trial evaluating the safety and efficacy of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus inadequately controlled by glimepiride and metformin
... antihyperglycemic agents to achieve glycemic control with disease progression. Omarigliptin is a once-weekly dipeptidyl peptidase-4 inhibitor. The purpose of this trial was to assess the efficacy and safety ...
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Real-world glycemic outcomes in patients with type 2 diabetes initiating exenatide once weekly and liraglutide once daily: a retrospective cohort study
... Sample selection and attrition are detailed in Table 1; 29,745 patients with an initial prescription of exenatide QW or lira- glutide QD as of February 1, 2012 were initially identified from the database. After applying ...
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Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data
... Abstract: Dulaglutide is a once-weekly glucagon-like peptide-1 receptor agonist, which has been on the market in the USA since 2014. Dulaglutide has performed well in head-to-head studies against metformin, ...
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Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
... Abstract: Exenatide (also known as exendin-4) is a glucagon-like peptide-1 mimetic, which is indicated for the treatment of type 2 diabetes mellitus. The currently available formulation of this drug is a twice-daily ...
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Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis
... mg) once-weekly increased the BMD (in 6%) after 2 years of treatment ...mg once a month provided similar efficacy and safety at 2 years compared with risedronate at 5 mg daily, for the treatment of ...
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Adherence to GLP-1 receptor agonist therapy administered by once-daily or once-weekly injection in patients with type 2 diabetes in Germany
... (vs once-daily liraglutide), younger age, female sex, living in southern USA, and higher percentage of copayment from the claimant were all associ- ated with poor 12-month ...
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Frequency and change mechanisms of psychotherapy among depressed patients: study protocol for a multicenter randomized trial comparing twice weekly versus once weekly sessions of CBT and IPT
... of once a ...than once-weekly sessions. If we find twice-weekly sessions to be more effective or to lead to more rapid recovery, this could lead to treatment adaptations that have the ...
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A dose increased once-weekly bortezomib-based combination therapy for multiple myeloma
... once-weekly bortezomib (51% vs 36%, P < 0.003), which was mainly related to reduction of severe sensory peripheral neuropathy (16% vs 3%, P < 0.001) [18]. The occurrences of hematologic toxicity, ...
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Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers
... panel. Once-weekly exenatide reduced apolipoprotein B and the apolipoprotein B to apolipoprotein A1 ratio (P , ...Exenatide once weekly increased high-density lipoprotein-2 cholesterol, even ...
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Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity.
... Semaglutide is a human GLP-1 analogue currently in develop- ment for the treatment of T2D, with a similar structure to liraglutide. Semaglutide has 94% structural homology with native human GLP-1 13 with three important ...
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Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes
... exenatide once weekly across all body weight change quartiles, even in those patients with small reduc- tions in body weight or small weight gain, demonstrating that exenatide improved glycemic control ...
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Application of Adult-Learning Principles to Patient Instructions: A Usability Study for an Exenatide Once-Weekly Injection Device
... Although it is highly desirable for patients to be formally educated by diabetes educators when initiat- ing a new medication, practical constraints (e.g., insufficient time, limited insurance coverage) and lack of ...
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Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years
... The once-weekly (QW) formulation of the glucagon-like peptide-1 receptor agonist exenatide has been demonstrated to improve A1C, fasting plasma glucose (FPG), body weight, serum lipid profiles, and blood ...
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Exenatide once-weekly injection for the treatment of type 2 diabetes in Chinese patients: current perspectives
... Fortunately, a number of new drugs have been developed in recent years. Some of the most popular hypoglycemic drugs include the glucagon-like peptide-1 (GLP-1) analogs and dipeptidyl peptidase (DPP)-4 inhibitors, which ...
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Emerging utility of once-weekly exenatide in patients with type 2 diabetes
... administered weekly or 10 µ g administered twice ...exenatide weekly group had a significantly greater change in HbA 1c than exenatide daily ( − ...receiving once-weekly exenatide achieved ...
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Once-weekly albiglutide in the management of type 2 diabetes: patient considerations
... compared once-weekly albiglutide ver- sus prandial insulin lispro, both combined with titrated insulin glargine (Table ...mg once weekly or meal-time insulin lispro and continued on home ...
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Once-Weekly Glucose-Lowering Therapy for Type 2 Diabetes
... Exenatide once weekly (QW), a glucagon-like peptide-1 (GLP-1) receptor agonist, is the first and only glucose-lowering therapy indicated for once-weekly administration with diet and exercise ...
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Exenatide once weekly: clinical outcomes and patient satisfaction
... Exenatide once-weekly is an incretin mimetic that is currently undergoing phase 3 clinical trials, and has been shown to improve glycemic parameters (HbA 1c and fasting and postprandial glucose levels), ...
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