oncogenic signaling
IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling
... STAT3 signaling is involved in promoting tumor cell proliferation, metastasis, invasion, angiogenesis and immunosuppression [36, ...TGF-β signaling pathways upon IL-37b ...STAT3 signaling and ...
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FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance
... cancer- signaling proteins including EGFR (FAM83B), PI3K (FAM83A-B), AKT (FAM83B), c-RAF (FAM83A-E) [22-25, ...of oncogenic signaling ...stabilize signaling complexes may suppress effector ...
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Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least Resistance
... alternate oncogenic signaling pathways in addition to FLT3 ...FLT3 signaling for treatment of AML, and suggest that monitoring FLT3 inhibition and ex vivo drug screening may help determine which FLT3 ...
35
Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
... downstream oncogenic signaling by activating PI3K in many tumors and escape various EGF receptors targeted ...HER3 oncogenic signaling [19, ...The signaling adaptor protein of Grb2 ...
15
FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer
... important oncogenic signaling molecules in human epithelial ovarian cancers ...the signaling molecules, and RNAi-mediated gene knock-down to uncover the molecular mechanisms of how these two ...
12
USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells
... and oncogenic signaling of mutant EGFR and indicates targeting USP17 could represent a viable therapeutic strategy in NSCLC tumours carrying either an EGFR activating mutation, or a resistance gatekeeper ...
12
Original Article CD47 is associated with the up-regulation of the PD-1 oncogenic signaling pathway
... (PD-1) signaling pathway were assessed by Western blot ...PD-L1 signaling pathway was found to be activated in TPC-1 and K1 cells, and the knockdown of CD47 significantly suppressed the activation of this ...
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Oncogenic Signaling Pathways in The Cancer Genome Atlas.
... potentially oncogenic alterations in SOS1 ...Ras signaling and results sug- gesting that multiple hits in the Ras pathway are capable of increasing overall Ras activity in RAS wild-type tumors (Way et ...
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Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells
... proteins, oncogenic Pim family kinases (Pim1-3) contribute to development of both hematopoietic malignancies and solid tumors [18-21] by supporting cell survival [22, 23], promoting cancer cell migration and ...
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Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes
... In all, our library was composed of 36 constructs capable of modulating 17 major signaling pathways. All constructs were fully sequenced to confirm fidelity to the original source and 86% (31/36) of constructs ...
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Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least Resistance
... 23. Jiang, J.; Paez, J. G.; Lee, J. C.; Bo, R.; Stone, R. M.; DeAngelo, D. J.; Galinsky, I.; Wolpin, B. M.; Jonasova, A.; Herman, P.; Fox, E. A.; Boggon, T. J.; Eck, M. J.; Weisberg, E.; Griffin, J. D.; Gilliland, D. G.; ...
7
Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma
... Cell-extracellular matrix interaction shows substantial impacts on cell fate because it is one of the major mechanical cues to regulate organ development and homeostasis [39, 40], and on the other hand, its pathological ...
13
Downregulation of the tumor suppressor miR 16 via progestin mediated oncogenic signaling contributes to breast cancer development
... Results: We found that nine miRNAs were upregulated and seven were downregulated by progestin in mammary tumor cells. miR-16, whose function as a tumor suppressor in leukemia has already been shown, was identified as one ...
21
TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling
... The specimens were paraffin embedded, and the tissue sections (3 μm) were dewaxed, rehydrated, blocked with 3% BSA and subjected to antigen retrieval. After being washed, the sections were incubated with antibodies ...
15
GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling
... PAK5 phosphorylates the transcription factor GATA1 mainly at Ser161 and Ser 187, phosphorylated GATA1 recruits more HDAC3/4 to the promoter of E-cadherin and consequently suppresses the [r] ...
12
LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients
... pre-BCR signaling is exerted together with the IL7R pathway, [21] which leads to Stat5 phosphorylation, and consequentially activation of cell cycle progression ...
13
Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
... Thus, oncogenic activation of the PI3K/PKB pathway and the PKB-dependent phosphoryla- tion of p27 is probably one of the mechanisms underlying the cytoplasmic mislocalization of p27 in human ...
9
CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins
... In the present study we have identified CPI-17 as a potent oncogene that is frequently misexpressed in different types of melanocytic tumors (Figure 3D- 3E, Figure 5, Table 1). Others have reported CPI-17 to be frequently ...
13
The Role of CYLD in Blocking Oncogenic Cell Signaling in Melanoma
... Dysregulation of components of the ubiqutin system has been linked to many diseases including melanoma. This is vital since the post-translational modification of different proteins via direct ubiquitin attachment is an ...
6
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF β signaling and metastasis
... of oncogenic β 3 integrin:TβR-II signaling ...abrogated oncogenic signaling by TGF-β and its ability to induce EMT, invasion, and systemic dissemination of breast cancer ...
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