Oncolytic adenovirus
CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth
... expressing oncolytic adenovirus ...the oncolytic adenoviruses as well as other therapeutic agents induced apoptosis signaling, pending further ...
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Oncolytic adenovirus armed with IL-24 Inhibits the growth of breast cancer in vitro and in vivo
... or adenovirus can specif- ically inhibit growth of tumor cells and induce tumor- specific apoptosis ...replication-defective adenovirus cannot target tumor cells, which limits its therapeutic ...the ...
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<p>Efficacy of a new oncolytic adenovirus armed with IL-13 against oral carcinoma models</p>
... of adenovirus and release of virus genome into the cancer cell ...ed adenovirus (MMAD) vector to enhance the antitumor ef fi cacy of oncolytic ...of adenovirus penton that facilitates virus ...
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In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus
... an oncolytic adenovirus that specifically kills prostate cells via restricted replication by a prostate-specific regulatory ...of oncolytic adenoviruses would have serious clinical ...coxsackie ...
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<p>Preclinical And Clinical Development Of Oncolytic Adenovirus For The Treatment Of Malignant Glioma</p>
... conditional oncolytic human adenovirus has long been considered a promising biological therapeutic to target high-grade gliomas (HGG), a group of essentially lethal primary brain ...of oncolytic ...
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Original Article Triple-controlled oncolytic adenovirus expressing melittin to exert inhibitory efficacy on hepatocellular carcinoma
... cancer-selective oncolytic adenovirus, QG511-HA- Melittin, carrying melittin gene, in which the hybrid promoter, hypoxia-response element (HRE)-AFP promoter, was used to control viral E1a expression ...
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Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy
... The association of the alpha defensin HD5 with cancer is less studied. HD5 is predominantly produced by and secreted from Paneth cells, specialized epithelial cells in the gastrointestinal (GI) tract (5). In Paneth ...
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Fc gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment
... on oncolytic virotherapy and therefore on the therapy ...to oncolytic virotherapy are poorly under- ...for oncolytic adenovirus therapies could eventually enable selection of patients ...
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Oncolytic adenovirus Ad657 for systemic virotherapy against prostate cancer
... effective oncolytic adenovirus, ...an oncolytic against human prostate ...C oncolytic virus called Ad657 for this ...systemic oncolytic therapies by single ...
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A novel Golgi protein (GOLPH2)-regulated oncolytic adenovirus exhibits potent antitumor efficacy in hepatocellular carcinoma
... by oncolytic adenovirus-mediated the transgene gene expression regulating by AFP promoter and proved certain efficacies in HCC model [20, ...GOLPH2-regulating oncolytic adenovirus for cancer ...
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A novel bladder cancer specific oncolytic adenovirus by CD46 and its effect combined with cisplatin against cancer cells of CAR negative expression
... cancer-specific oncolytic adenovirus Ad-PSCAE-UPII-E1A [17, 18]. This adenovirus is a dual specific vector which contains prostate stem cell antigen enhancer (PSCAE) and human uroplakin II (hUPII) ...
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Oncolytic adenovirus-mediated therapy for prostate cancer
... conclude oncolytic adenoviruses armed with immune stimulatory factors and cytotoxic transgenes are the most promising way forward to target both early- and late-stage prostate cancers, and with additional capsid ...
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Effect of Preexisting Immunity on Oncolytic Adenovirus Vector INGN 007 Antitumor Efficacy in Immunocompetent and Immunosuppressed Syrian Hamsters
... an oncolytic adenovirus serotype 5 (Ad5)-based vector was ap- proved for cancer therapy in humans for the first time (14, ...42). Oncolytic vectors based on Ad, reovirus, herpes simplex virus type 1 ...
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Designer Oncolytic Adenovirus: Coming of Age
... for oncolytic virotherapy, since it provided unequivocal evidence for the long-touted potential of genetically modified replicating viruses as anti-cancer ...is oncolytic adenovirus (Ad); it’s double ...
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Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells
... To test the effect of the fusion protein on β-catenin local- ization, SW480 cells were infected with the parental and E1A-HD2 viruses. E1A has a strong nuclear localization signal (NLS) [21], and its nuclear localization ...
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Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells
... as adenovirus and human cytomegalovirus stimulate metabolic alternations such as glycolysis in the host cells to generate energy and essential elements for viral repli- cation ...by adenovirus to create a ...
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YB 1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
... contained a RGD motif to increase infectivity in glioma cells. However, brain CSC show high CAR expression; hence the infection of CSC occurs also independent from RGD-fiber modification (data not shown). Here we dem- ...
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Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma
... Abstract: Conditionally replicating adenoviruses have emerged as novel therapeutic agents for cancer. This study aimed to evaluate synergistic antitumor activity of replication-competent adenovirus armed with ...
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Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells
... control adenovirus activity when the 3’UTR of the E1A gene was genetically engineered with miRNA binding sites recognizing miR-148a ...targeted adenovirus regulating the L5 gene by insertion of 8 copies of ...
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Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy
... that adenovirus type 3 [29–31] along with adenoviral type 11 and 35 [32] recognize CD46 as the primary ...of adenovirus type 35 as desmoglein 2 (DSG2). Type 3 adenovirus uses an unknown receptor (X), ...
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