oncolytic virotherapy
Patient-derived mesenchymal stem cells as delivery vehicles for oncolytic virotherapy: novel state-of-the-art technology
... Abstract: Oncolytic virotherapy is gaining interest in the clinic as a new weapon against ...of oncolytic viruses showed important limitations that decrease their effectiveness very significantly: ...
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Bacterial glucuronidase as general marker for oncolytic virotherapy or other biological therapies
... Biological therapies, like e.g. oncolytic virotherapy, are dependend on the expression of genes that are not func- tionally expressed in the respective patient. We recently described the use the rVACV ...
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Oncolytic virotherapy in upper gastrointestinal tract cancers
... times. Oncolytic viruses are being developed to address these malignancies, with a focus on high safety profiles and low off-target ...enhance oncolytic potency and the clinical response to either single- ...
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Thyroid malignant neoplasm-associated biomarkers as targets for oncolytic virotherapy
... of oncolytic virotherapy, until now, the work on the seven TMN biomarkers, except for NIS, has not been studied and clinical trials have not been ...the oncolytic virus to the tumor cell, and in ...
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Oncolytic virotherapy for pediatric malignancies: future prospects
... Abstract: Pediatric solid tumors remain a major health concern, with nearly 16,000 children diagnosed each year. Of those, ~2,000 succumb to their disease, and survivors often suffer from lifelong disability secondary to ...
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Progress in oncolytic virotherapy for the treatment of thyroid malignant neoplasm
... [4]. Oncolytic virotherapy is a promising anti-cancer strategy, because it can provide a local regional control, or eradication of tumors without cross-interference with standard therapies ...[5]. ...
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Chemovirotherapy: combining chemotherapeutic treatment with oncolytic virotherapy
... Abstract: Oncolytic virotherapy has made significant progress in recent years, however, widespread approval of viro therapeutics is still ...of virotherapy with highly geno toxic regimens, such as ...
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Overcoming the limitations of locally administered oncolytic virotherapy
... for oncolytic virotherapy, by having the gel matrix functioning as a protective reser- voir to shield the virus from host immune system while preserving the antitumor immunity of the ...
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Oncolytic virotherapy for human malignant mesothelioma: recent advances
... different oncolytic viruses by direct killing or by immune-mediated ...of oncolytic virotherapy for this specific malignancy and would hope- fully provide a brighter prospect for patients afflicted ...
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Targeting tumor vasculature through oncolytic virotherapy: recent advances
... The oncolytic virotherapy field has made significant advances in the last decade, with a rapidly increasing number of early- and late-stage clinical trials, some of them showing safety and promising ...
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A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma
... tissues irrespective of MEK and PI 3-kinase activities in the tumor cells. This would explain the difference between HF and RH2 in the antitumor effect and virus yield. It should be also stated that the phenotype of RH2, ...
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Mutations in the Glycoprotein of Vesicular Stomatitis Virus Affect Cytopathogenicity: Potential for Oncolytic Virotherapy
... for oncolytic virotherapy due to its capacity to selectively lyse tumor ...multiple oncolytic viruses will be needed to effectively treat most ...
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Emerging role of Natural killer cells in oncolytic virotherapy
... therapies. Oncolytic viruses are novel anticancer agents showing selective tropism for tumor cells and lacking pathogenicity in humans, but the use of oncolytic virotherapy (OVT) presents multiple ...
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Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances
... Abstract: Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have recently passed the randomized Phase III clinical trial ...Single-agent oncolytic virotherapy ...
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Type I Interferon-Sensitive Recombinant Newcastle Disease Virus for Oncolytic Virotherapy
... The genetic malleability, tumor selectivity and high thera- peutic index of NDV are the most desirable properties for an oncolytic virus. With the advent of a reverse-genetics system for NDV, it is now possible to ...
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Oncolytic virotherapy for ovarian cancer
... 2. What are the operative mechanisms for OV-mediated antiovarian cancer effects? The parameters that determine the susceptibility of individual ovarian cancer patients to virotherapy is still not clear in clinical ...
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Oncolytic virotherapy: the questions and the promise
... Abstract: Oncolytic virotherapy is a new strategy to reduce tumor burden through selective virus replication in rapidly proliferating ...cells. Oncolytic viruses are members of at least ten virus ...
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Oncolytic virotherapy for head and neck cancer: current research and future developments
... needed. Oncolytic virotherapy holds promise in this regard as viruses can be injected intratumorally as well as intravenously with excellent safety ...in oncolytic virotherapy, highlighting ...
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MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
... of oncolytic virotherapy for cancer treatment has been well demonstrated, justifying the continued devel- opment of novel oncolytic viruses with enhanced ...novel oncolytic agent. Mengovi- rus ...
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Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients
... mouse cells. Thus, certain permissive cancer cells are grown in immunocompetent animals to study virus replication [121,122]. However, artificial establishment of these tumors as subcutaneous xenografts raises con- cern ...
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