ONOO−, peroxynitrite
Effect of Peroxynitrite (ONOO ) on the Function of Murine Perivascular Adipose Tissue
... Perivascular adipose tissue (PVAT) surrounds the exterior of blood vessels and releases numerous substances such as adiponectin which positively modulate blood vessel tone. In some cardiovascular diseases such as ...
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Deciphering the molecular signaling cascade in neuronal death
... ONOO-: peroxynitrite PCD: programmed cell death PCR: polymerase chain reaction PD: Parkinson‘s disease PERK: PKR-like ER kinase PI: propidium iodide PKC: protein kinase C PKG: protein ki[r] ...
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The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells
... of peroxynitrite (ONOO - ) has been linked to atherogenesis and its clinical manifesta- tions ...of ONOO - . Peroxynitrite, a major component of nitroxidative stress, is cytotoxic and can ...
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The pathophysiological role of mitochondrial oxidative stress in lung diseases
... Abbreviations ROS: reactive oxygen species; mtDNA: mitochondrial DNA; O·− 2 : superoxide anion; ·OH: hydroxyl radical; ONOO−: peroxynitrite molecule; SOD: superoxide dismutase; Cl−: chlo[r] ...
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Nitric Oxide and Peroxynitrite: Effects on Cardiovascular Function
... 652 ADP-ribose polymers become attached to a variety of proteins, whose function becomes thereby modulated [116]. The major collateral damage related to PARP activation is the severe depletion of cellular NAD + stores, ...
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Study on the Effect of Several Natural Products on Tyrosine Damage Induced by Peroxynitrite
... stable semiquinone free radical, thereby blocking the free radical reaction, this semiquinone structure can blocks free radical reactions. Intramolecular hydrogen bonding, C=C, and the existence of carbonyl and p-π ...
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Oxidative photoreceptor cell damage in autoimmune uveitis
... by ONOO − which results in mitochondrial oxidative stress ...factors ONOO − and tumor necrosis factor- α (TNF- α ) ...retinal ONOO − initiated damage occurred before there was any histologic or ...
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Nitric Oxide/Peroxynitrite Redox Imbalance in Endothelial Cells Measured with Amperometric Nanosensors
... trode; a silver/silver chloride (Ag/AgCl) as reference electrode, and a platinum wire (diameter 0.1 mm) as a counter electrode. Amperometric measurement was per- formed by using a computer-controlled Gamry VFP600 ...
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Subanesthetic isoflurane relieves zymosan-induced neutrophil inflammatory response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling
... To investigate whether the reduction of lung microvascular injury by isoflurane is dependent on iNOS activation in zymosan-challenged neutrophils in mice, we established a neutrophil-depleted mouse model by ...
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Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D<sub>3</sub> – clinical implications for cardiovascular diseases
... and NADPH oxidase. All of these molecules and their sources may contribute to shift in oxidative/nitroxidative stress and bioavailability of NO. Upregulated expression of these three enzymes may lead to excessive ...
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Evaluating the use of 3'-(p-Aminophenyl) fluorescein for determining the formation of highly reactive oxygen species in particle suspensions
... 3'-( p -Aminophenyl) fluorescein (APF) is a non-fluores- cent molecule until it is reacted with either hydroxyl radi- cals, hypochlorite ( - OCl), peroxynitrite anions (ONOO - ) [21] or [r] ...
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P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
... and ONOO − were diminished in BBG treated ICH rats, indicating that they may be downstream of P2X7R as previously reported [26, ...of ONOO − in NLRP3 inflammasome ...specific ONOO − decom- position ...
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Role of nitric oxide and peroxynitrite in the cytokine induced sustained myocardial dysfunction in dogs in vivo
... that peroxynitrite (as indicated by the ap- pearance of nitrotyrosine) is, indeed, formed in vivo after cere- bral ischemia/reperfusion ...of peroxynitrite could cause sustained myocardial dys- function in ...
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The influence of lipoproteins and peroxides on platelet activation and inhibition
... Incubation of peroxynitrite for Imin prior to addition of thrombin (0.02U/ml) resulted in a concentration- dependent inhibition of platelet aggregation [Figure 4.9]. The[r] ...
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Effects of carbon dioxide on damage of amino acids induced by peroxynitrite
... In addition, we also made a quantitative analysis of the above reaction and the results were shown in Table-2. The detection wavelength was 280 nm and the initial concentration of Tyr was 100.0%. The Table-2 showed that ...
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Amorphus Silica Nanopartilces Aggregate Human Platelets: Potential Implications for Vascular Haemostasis
... .11,12 Indeed, platelet-derived and exogenous ONOO- induce TXA2 formation,31 nitration of tyrosine-containing proteins,32 SELP expression and GPIIb/IIIa activation.12 The activation of [r] ...
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Renal hypoperfusion and impaired endothelium dependent vasodilation in an animal model of VILI: the role of the peroxynitrite PARP pathway
... by peroxynitrite have not been studied ...by peroxynitrite attenuates VILI and renal hypoperfusion and dysfunction, by maintaining endothelium-dependent vasodilation and decreasing inflammation and tissue ...
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Anti-Inflammatory Effect of the Epigallocatechin Gallate Following Spinal Cord Trauma in Rat
... Peroxynitrite, a cytotoxic molecule produced in the spinal cord tissue following trauma, contributes to the post-traumatic inflammatory reaction including tyrosine nitration and lipid peroxidation [26], and also ...
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Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function
... superoxide, peroxynitrite, and H 2 O 2 occupy the center stage in a functional ...of peroxynitrite and H 2 O 2 seems to become excessive, leading to endothelial ...
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Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis
... Timmins, “Oxidative stress response genes in Mycobacterium tuberculosis: role of ahpC in resistance to peroxynitrite and stage-specific survival in macrophages,” Microbiology, vol.. Wayne[r] ...
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