OPLS-DA
Original Article Serum metabonomic analysis of rats with cisplatin-induced nephrotoxicity and panax notoginseng saponins treatment
... and OPLS-DA scores plots of serum samples showed that the normal control group was clearly separated from the cisplatin-only group and the cisplatin- PNS group, while there was a part overlap between the ...
11
NMR Metabolomic Study on Monocultivar and Blend Salento EVOOs including Some from Secular Olive Trees
... As reported in details in the experimental section, three different bucket datasets were generated from NMR spectra: BUCKET-1 was obtained within the range 10.0 - 0.5 ppm, BUCKET-2 was obtained within the range 10.0 - ...
7
A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study
... the OPLS-DA models was determined by iteratively excluding the vari- ables with low regression coefficients and wide confidence intervals derived from jackknifing combined with low variable importance in ...
12
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans
... In a comparison of low HC vs high HC, 23 putative biomarkers (Table S2) passed the 95% CI filter and showed significant change based on FDR corrected p values, and had an AUC above 0.7. These 23 putative biomarkers were ...
10
Metabolic evaluation of the effects of a hyperlipid diet for obesity induction and standard normolipid diet (ain 93) consumption in wistar rats
... For the results of the physical-chemical analysis of the experimental diets and biological data, the Student t-test was used, considering p < 0.05 as the minimum probability between means. For the statistical ...
11
Early prediction of cerebral malaria by 1H NMR based metabolomics
... not appear to play any discriminatory role in CM versus NCM at days 3–4 pi although on day 5 enhanced level of glucose is observed in NCM sera compared to CM. Moreover, serum lactate does not contribute significantly ...
10
Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale
... Raw (unrarefied) OTU abundance data were imported into R for analyses using Phyloseq [34] (Additional files 5 and 6). A phylogenetic tree was generated using MEGA v7.0 [35] and rooted to a random node using the R pack- ...
10
Metabolomic Profiling of Post-Mortem Brain Reveals Changes in Amino Acid and Glucose Metabolism in Mental Illness Compared with Controls
... There are many other differences in the univariate data and it is dif- fi cult to rationalise them all. In order to determine if there are subgroups within the samples, a PCA model was fi tted to the 36 samples used to ...
11
Original Article Potential urinary metabolite markers for diagnosing gastric cancer
... ess the quality of the built OPLS-DA model [14]. The 299-iteration permutation test was ap- plied to check whether there was over-fitting or not. Variable Importance in Projection (VIP) score indicates the ...
8
Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia
... Addtitional file 2: Tables S7-S12 and Figures S11–S13. Table 5 shows the identified biological pathways in- volved, based on the most important metabolites found by NMR and GC-MS analyses, in the diagnosis of H1N1 ...
15
Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients
... an OPLS-DA prediction model was built using subjects in the training set (adenocarcinoma patients (n=12) and control patients (n=11) to predict adenocarcinoma patients (adenocarcinoma patients (n=5) and ...
36
<p>CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia</p>
... osteoglycin; OPLS-DA, orthogonal partial least squares – discriminant analysis; PCA, principal component analysis; PTGDS, pros- taglandin-H2 D-isomerase; S1P, sphingosine-1-phosphate; SCG1, secretogranin-1; ...
15
Metabolomic approach to profile functional and metabolic changes in heart failure
... The OPLS-DA model maximizes the covariance between the measured data of the X-var- iable (peak intensities in NMR spectra) and the response of the Y-variable (class assignment) within the ...the ...
11
A Study for Transition of Vitamin C and Water Through Channel Membrane and Channel Aquaporin
... The accuracy of the method is defined by a random displacement. In this investigation, differences of force fields are shown by comparing the calculated energies using AMBER and OPLS. In this investigation ...
6
Análise espacial da centralidade e da dispersão da riqueza gaúcha de 1970 a 2000: notas preliminares
... Particularmente, a análise espacial focaliza aspectos específicos concernentes aos dados e aos modelos utilizados. Anselin (1988; 1992) denomina esses aspectos de efeitos espaciais sobre os dados e os divide em dois ...
37
High-Temperature unfolding of a trp-Cage mini-protein: a molecular dynamics simulation study
... carry out the 5 ns simulations and similar results were obtained with each. Results presented here correspond to model 1. All simulations were carried out using GROMACS 3.2 [8,9], running on a single Fedora Linux system. ...
5
Da Pena Privativa de Liberdade: Controle da Crimilalidade?
... jurídico da propriedade, todas as práticas populares que se classificavam, seja numa forma silenciosa, cotidiana, tolerada, seja numa forma violenta, na ilegalidade dos direitos, são desviadas à força para a ...
15
Pair configurations to molecular activity coefficients: PAC-MAC
... Therefore, an extensive accuracy test of the OPLS-AA force field is performed in Chapter V by comparing the excess free energy of mixing, calculated using thermodynamic i[r] ...
161
Aspectos desencadeantes da síndrome de burnout em enfermeiros da estratégia saúde da família
... desencadeantes da síndrome de burnout em enfermeiros da ...Dados da Enfermagem (BDENF); Literatura Latino-Americana e do Caribe em Ciências de Saúde ...profissionais da enfermagem, que por ...
5
Reforma da Administração Pública: Antes e Depois da Democracia
... (princípio da procura e não o da oferta ou do controlo) ou, ainda, facilitado no suporte por uso de algum meio de troca e de envio e entrega do próprio ...dimensões da regularidade e concentração, ...
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