orexin-A
Original Article Orexin A stimulates Foxo1 phosphorylation via OX1R-induced PI3K/AKT and MAPK/ERK signaling pathways in hepatocytes
... Abstract: Orexin A and B are multifunctional neuropeptides implicated in the regulation of food intake, energy me- tabolism, glucose regulation, and ...(GPCR), orexin receptor 1 and orexin receptor 2 ...
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Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation
... delivered orexin A effects may modulate local (CNS) and/or peripheral immune ...found orexin receptor expression in both CNS and im- mune tissues of naïve ...hypothalamic orexin receptor mRNA ...
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Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
... Ventriculography performed to assist in the proper placement of an electrode in the subthalamic nucleus require the removal of CSF just before the injection of the contrast agent into the ventricle. In each of our ...
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Effect of Orexin-A on Glucose Sensitive Neurons in the Hypothalamus of Rats
... Abstract: Orexin-A is an excitatory neuropeptide that mainly located in the lateral ...hypothalamus(LHA). Orexin-A can regulates multiple physiological activity that include arousal, wakefulness and ...of ...
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Effect of orexin A on prolactin secretion in lambs born under different photoperiod conditions – in vitro study
... (experimental orexin pituitary glands group: Ox1 – May, Ox2 – August, Ox3 – December) was incubated in Parker’s medium containing 1000 ng/ml of orexin-A ...of orexin-A was based both on theoretical ...
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<p>Reduced plasma orexin-A levels in patients with bipolar disorder</p>
... recently, orexin has been studied extensively in patients with narcolepsy whose cerebrospinal fl uid (CSF) orexin levels were found to be very ...The orexin system plays a role not only in sleep awake ...
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Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post laparotomy pain
... OXB [14]. This neuropeptide arrangement functions in multiple physiological processes, such as the regulation of sleep and arousal, feeding behavior, metabolism and noci- ception. Growing evidence from morphological and ...
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Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
... that orexin was involved in the induction of stress ...of orexin A and B and OX1R and OX2R are unknown, but we plan to conduct experiments in the future to determine whether they have separate roles in the ...
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The role of orexin in post-stroke inflammation, cognitive decline, and depression
... [13,14]. Orexin peptides (orexin-A and orexin-B) pro- duced by the lateral hypothalamus are known to regulate feeding, energy homeostasis, neuroendocrine activities, and the sleep-wake cycle by ...
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Unilateral Hypothalamus Inactivation Prevents PTZ Kindling Development through Hippocampal Orexin Receptor 1 Modulation
... Under the mentioned anesthesia, stereotaxic injection of lidocaine 2% was performed into LHA (13 times, each 30 min before PTZ treatment) to inactivate the region, transiently. Orexin-A (10 nM (Aou et al., 2003)) ...
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Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats
... LH orexin neurons or intra-VTA administra- tion of the orexin-A peptide reinstated morphine-seeking as measured by the CPP (Harris, Wimmer, & Aston-Jones, ...investigated orexin-A (non- selective ...
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Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain
... significantly increased the blood levels of glucose, cholesterol, and triglycerides. Fructose modified the sleep-wake cycle of rats increasing the waking duration and conversely decreasing the non-rapid eye movement ...
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Neuroendocrine regulation of feeding behaviour
... Orexin neurons are regulated by metabolic cues, including leptin, glucose, and ghrelin.Orexin mRNA expression is up-regulated by fasting and insulin-induced hypoglycemia.Orexin-A increas[r] ...
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The in vitro effect of progesterone on the orexin system in porcine uterine tissues during early pregnancy
... Background: Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the ...
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The hypocretin/orexin system in sleep disorders: preclinical insights and clinical progress
... Abstract: Much of the understanding of the hypocretin/orexin (HCRT/OX) system in sleep– wake regulation came from narcolepsy–cataplexy research. The neuropeptides hypocretin-1 and -2/orexin-A and -B (HCRT-1 ...
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Dual agonist occupancy of orexin receptor 1 and cholecystokinin A receptor heterodimers decreases G protein dependent signaling and migration in the human colon cancer cell line HT 29
... of orexin receptor and corticotropin-releasing factor receptor serve as targets for cocaine and promote long-term disruption of negative crosstalk between orexin-A and CRF ...by orexin-A ...both ...
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Conditioned place preference training prevents hippocampal depotentiation in an orexin-dependent manner
... that orexin A can attenuate theta bust stimulation (TBS)-induced LTP at micromolar concentrations while prevented LFS-induced depotentiation, namely inducing re-potentiation, at sub-nanomolar concentrations at ...
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Novel class of medications, orexin receptor antagonists, in the treatment of insomnia – critical appraisal of suvorexant
... Dual orexin receptor antagonists represent a new class of medications for the treatment of insomnia, which block the binding of wakefulness-promoting neuropeptides orexin A and orexin B to their ...
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Non-Destructive Determination of Magnetic Audio Tape Degradation for Various Tape Chemistries Using Spectroscopy and Chemometrics
... the orexin/hypocretin (hereafter referred to as orexin) system by two separate laboratories in ...peptides orexin-A/orexin-B (OxA/OxB) after the Latin word ‘orexis’ meaning appetite (Sakurai ...
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Effect of Resistance Training on Appetite Regulation and Level of Related Peptidesin Sedentary Healthy Men
... Inactive lifestyle impairs appetite regulation, whereas exercise training affects nutrition, behavior and energy homeostasis. Resistance training is an essential part of any weight management program. The effectiveness ...
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