Orexin-B
Effect of orexin B saporin induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule
... The rats were divided into two groups. The first group received bilateral lesions of the LHA with the orexin-B-saporin conjugate (OxSap: Advanced Targeted Systems, USA) (n=14). The control group was divided ...
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Functional cardiac orexin receptors : role of orexin B/orexin 2 receptor in myocardial protection
... In the present study, using an OX1R antagonist and an OX2R agonist, we conclude that the primary signalling at the rat heart is mediated via an OR-B/OX2R pathway. OXRs are able to activate certain key ...
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Non-Destructive Determination of Magnetic Audio Tape Degradation for Various Tape Chemistries Using Spectroscopy and Chemometrics
... in orexin receptors as potential therapeutic targets. The two orexin peptides, OxA and orexin-B, act on two G protein-coupled receptors, with the orexin-1 receptor (Ox1R) binding OxA ...
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Novel class of medications, orexin receptor antagonists, in the treatment of insomnia – critical appraisal of suvorexant
... Dual orexin receptor antagonists represent a new class of medications for the treatment of insomnia, which block the binding of wakefulness-promoting neuropeptides orexin A and orexin B to ...
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Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation
... delivered orexin A effects may modulate local (CNS) and/or peripheral immune ...found orexin receptor expression in both CNS and im- mune tissues of naïve ...hypothalamic orexin receptor mRNA ...
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<p>Reduced plasma orexin-A levels in patients with bipolar disorder</p>
... that orexin-A (but not orexin-B) is highly lipophilic and rapidly crosses from the brain to the periphery through the blood-brain barrier (BBB) by means of a nonsaturable ...CSF orexin-A ...
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Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats
... LH orexin neurons or intra-VTA administra- tion of the orexin-A peptide reinstated morphine-seeking as measured by the CPP (Harris, Wimmer, & Aston-Jones, ...investigated orexin-A (non- selective ...
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The role of orexin in post-stroke inflammation, cognitive decline, and depression
... [13,14]. Orexin peptides (orexin-A and orexin-B) pro- duced by the lateral hypothalamus are known to regulate feeding, energy homeostasis, neuroendocrine activities, and the sleep-wake cycle ...
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Unilateral Hypothalamus Inactivation Prevents PTZ Kindling Development through Hippocampal Orexin Receptor 1 Modulation
... in, orexin-A and orexin-B, and orexin receptor is a mem- ber of GPCR family with two receptor subtypes; orexin receptor 1 (OX1R) and orexin receptor 2 ...both orexin ...
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The in vitro effect of progesterone on the orexin system in porcine uterine tissues during early pregnancy
... Background: Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the ...
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Profile of suvorexant in the management of insomnia
... Abstract: Suvorexant, approved in late 2014 in the United States and Japan for the treat- ment of insomnia characterized by difficulty achieving and/or maintaining sleep, is a dual orexin receptor antagonist and ...
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Suvorexant: a promising, novel treatment for insomnia
... of orexin antagonists over other ...specific orexin recep- tors, it is less likely to cause major side effects (residual next-day sleepiness, drowsy driving, and undesired behaviors in ...
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Effect of Resistance Training on Appetite Regulation and Level of Related Peptidesin Sedentary Healthy Men
... and orexin have key roles in appetite ...(8). Orexin or hypocretinis a recently discovered neuropeptide synthetized mainly by neurons located in the posterolateral ...
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The hypocretin/orexin system in sleep disorders: preclinical insights and clinical progress
... Abstract: Much of the understanding of the hypocretin/orexin (HCRT/OX) system in sleep– wake regulation came from narcolepsy–cataplexy research. The neuropeptides hypocretin-1 and -2/orexin-A and -B ...
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Neuroendocrine regulation of feeding behaviour
... Orexin neurons are regulated by metabolic cues, including leptin, glucose, and ghrelin.Orexin mRNA expression is up-regulated by fasting and insulin-induced hypoglycemia.Orexin-A increas[r] ...
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Original Article Orexin A stimulates Foxo1 phosphorylation via OX1R-induced PI3K/AKT and MAPK/ERK signaling pathways in hepatocytes
... by orexin A stimulation is due to ...(U0126), orexin A-induced Foxo1 phosphoryla- tion was ...hepatocytes, orexin A induced Foxo1 phosphorylation is mediated through both PI3K/AKT and MAPK/ ERK ...
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Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
... plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin ...of orexin and corticosterone were ...and orexin significantly ...
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Conditioned place preference training prevents hippocampal depotentiation in an orexin-dependent manner
... that orexin A can attenuate theta bust stimulation (TBS)-induced LTP at micromolar concentrations while prevented LFS-induced depotentiation, namely inducing re-potentiation, at sub-nanomolar concentrations at ...
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Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post laparotomy pain
... The present study showed that intrathecal injection of OXA can relieve the pain state induced by laparotomy, and that this effect was antagonized by the selective OX1R antagonist SB-334867. The OXA analgesia effect of ...
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Formulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies
... treatment B in study I, B) a single 25 mg dose of a liquid-filled hard gelatin capsule developed to increase the absolute bioavailability of almorex- ant, administered as one 25 mg capsule, and C) a single ...
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