orexin receptors
Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103
... hippocampal orexin receptors (OXRs) and GPR103 particularly in the cornu ammonis (CA) subfield from AD patients suffering from early onset familial AD (EOFAD) and late onset familial AD ...
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Functional cardiac orexin receptors : role of orexin B/orexin 2 receptor in myocardial protection
... This phenomenon has been previously described for other GPCRs. In the case of smooth muscle cell CRH-receptors, urocortin, but not CRH, activated the MAPK signal transduction pathway despite similar binding ...
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The in vitro effect of progesterone on the orexin system in porcine uterine tissues during early pregnancy
... in orexin concen- trations in the brain stimulates appetite and food dep- rivation results in an increased expression of the orexin system in the brain ...between orexin receptors in the ...
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Original Article Orexin A stimulates Foxo1 phosphorylation via OX1R-induced PI3K/AKT and MAPK/ERK signaling pathways in hepatocytes
... presents orexin A-induced and OX1R-mediated PI3K/AKT and MAPK/ERK1/2 signaling in ...hepatocytes. Orexin A upregulated ERK1/2 and AKT phosphorylation, in a dose- dependent ...that orexin A stimulates ...
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Non-Destructive Determination of Magnetic Audio Tape Degradation for Various Tape Chemistries Using Spectroscopy and Chemometrics
... in orexin receptors as potential therapeutic targets. The two orexin peptides, OxA and orexin-B, act on two G protein-coupled receptors, with the orexin-1 receptor (Ox1R) binding ...
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Unilateral Hypothalamus Inactivation Prevents PTZ Kindling Development through Hippocampal Orexin Receptor 1 Modulation
... Orexin receptors are distributed in different brain areas and their stimulation results in vigilance and wakeful- ness (Bonnavion & de Lecea, 2010; Boutrel et ...of orexin receptors could ...
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Effect of orexin A on prolactin secretion in lambs born under different photoperiod conditions – in vitro study
... that orexin has a stimulating effect on prolactin secretion (Molik et ...to orexin during the short days was weaker than on long days, most likely because of lactotropic resistance to ...to orexin ...
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The role of orexin in post-stroke inflammation, cognitive decline, and depression
... of orexin A than normal individuals [157,158]. Activation of orexin receptors promotes intracellular calcium influx through various intracellular signaling cascades that induce long- term ...
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Profile of suvorexant in the management of insomnia
... the orexin receptors, phar- maceutical development ...both receptors, providing foundations on which to design molecules with pharmaco- logically important ...
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The orexin/receptor system : molecular mechanism and therapeutic potential for neurological diseases
... Although orexin-containing neurons are distributed only in the LH and adjacent areas, their nerve fibers project widely to multiple brain regions (Chen et ...Furthermore, orexin receptors exhibit a ...
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Orexin neurons suppress narcolepsy via 2 distinct efferent pathways
... of orexin neurons, we selected the serotonergic DR, noradrener- gic LC, histaminergic TMN, and cholinergic PPT for 4 reasons: (a) these monoaminergic and cholinergic nuclei have long been implicated in ...
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Neuroendocrine regulation of feeding behaviour
... related protein was discovered as an endogenously released neuropeptide that acts as an inverse agonist for the melanocortin receptors, MC3R/MC4. AgRP is co-expressed in hunger activated neurons with NPY, another ...
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<p>Reduced plasma orexin-A levels in patients with bipolar disorder</p>
... recently, orexin has been studied extensively in patients with narcolepsy whose cerebrospinal fl uid (CSF) orexin levels were found to be very ...The orexin system plays a role not only in sleep awake ...
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The hypocretin/orexin system in sleep disorders: preclinical insights and clinical progress
... Abstract: Much of the understanding of the hypocretin/orexin (HCRT/OX) system in sleep– wake regulation came from narcolepsy–cataplexy research. The neuropeptides hypocretin-1 and -2/orexin-A and -B (HCRT-1 ...
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Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
... plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin ...of orexin and corticosterone were ...and orexin significantly ...
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Effect of Resistance Training on Appetite Regulation and Level of Related Peptidesin Sedentary Healthy Men
... that orexin promotion plays an important role in perceived appetite after resistance ...with orexin-producing neurons in the rat ...that orexin can respond to energy expenditure in a compensatory ...
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Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
... CSF orexin levels exhibited larger numbers of RSWA epochs than did patients with lower orexin levels, suggesting that preserved orexin drive may be involved in loss of REM ...that orexin ...
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Role of oleoylethanolamide as a feeding regulator in goldfish
... Oleoylethanolamide (OEA) is a bioactive lipid mediator, produced in the intestine and other tissues, which is involved in energy balance regulation in mammals, modulating feeding and lipid metabolism. The purpose of the ...
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Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats
... that orexin trans- mission play a key role in expression, extinction, and re- instatement of drug (Harris, Wimmer, & Aston-Jones, 2005; Smith, See, & Aston Jones, 2009; Guo et ...that orexin ...
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Suvorexant: a promising, novel treatment for insomnia
... novel, orexin receptor antagonist was recently approved by the US Food and Drug Administration for the treatment of sleep onset and sleep maintenance insomnia in August ...
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