Organic anion transporting polypeptides
Characterization of tick organic anion transporting polypeptides (OATPs) upon bacterial and viral infections
... 23. Radulovic Z, Porter LM, Kim TK, Mulenga A. Comparative bioinformatics, temporal and spatial expression analyses of Ixodes scapularis organic anion transporting polypeptides. Ticks Tick ...
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Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene
... elucidated. Organic anion- transporting polypeptides (OATP) appear to be particu- larly important in the disposition of many drugs in clin- ical use ...
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Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets
... of organic anion-transporting polypeptides in a wide range of cancers along with their unique capacity for energy-independent intracellular transport of xenobiotics makes them reasonable ...
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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
... Introduction Organic anion transporting polypeptides (rodents: Oatps, human: OATPs) are important membrane transport pro- teins that mediate the sodium-independent transport of a wide range of ...
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Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions
... Abstract: Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important hepatic transporters that mediate the uptake of many clinically important drugs, including statins from ...
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EFFECT OF PINEAPPLE (ANANAS COMOSUS) AND UZIZA (PIPER GUINEENSE) EXTRACTS ON FEXOFENADINE BIOAVAILABILITY: POSSIBLE ROLE OF P-GLYCOPROTEIN (P-GP) AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs)
... of organic anion transporting polypeptides (OATPs) during the intestinal absorption suggesting that the combined use of pineapple or uziza- containing diet with fexofenadine may require close ...
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Statin Transport by Hepatic Organic Anion-Transporting Polypeptides (OATPs)
... Multiple linear regression analysis indicated that plasma rosuvastatin concentration was higher in individuals with the reduced function hepatic uptake transporter allele SLCO1B1 c.5[r] ...
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Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide
... Because catalposide is an anionic weak acid, it can be speculated that MRP transporters may be involved in its membrane transport. MRP transporters are known to efflux organic anions as well as glucuronidated, ...
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Arthropod Organic Anion Transporting Polypeptides in Tick-Borne Bacterial and Viral Infections
... phagocytophilum modulates a specific tick host organic anion transporting polypeptide (isoatp4056) and kynurenine aminotransferase (kat), a gene responsible for the production of metab[r] ...
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Substrate Dependent Alterations of Organic Anion Transporting Polypeptide 1B3 (OATP1B3)
... membranes. Organic anion transporting polypeptides (OATPs) are multispecific transporters that are expressed in epithelia throughout the body and are largely responsible for the Na + ...
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P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions
... Abstract: Periplocin, an active and toxic component of the traditional Chinese herbal medicine Periploca sepium Bge, is a cardiac glycoside compound that has been implicated in various clinical accidents. This study ...
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Molecular and biological characterization of the Amblyomma americanum organic anion transporter polypeptide
... The organic anion transporting polypeptides (Oatps in rodents and other organism; OATPs in human) are Na + -independent transporters that shuttle a wide range of endogenous and xenobotic ...
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Localization of organic anion transporting polypeptide (Oatp) 1a4 and Oatp1c1 at the rat blood-retinal barrier
... media, polypeptides free of GST were obtained by elution of the cleaved polypeptide after in-column thrombin digestion of fusion proteins bound to glutathione-Sepharose ...
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Effects of Organic Anion Transporting Polypeptide (OATP1B1/SLCO1B1) Genetic Polymorphism on Statin Therapy
... Key words: Clinical significance, Genetic polymorphism, OATP1B1, SLCO1B1, Statins. INTRODUCTION The organic anion transporter protein 1B1 (OATP1B1) is the major transporter responsible for hepatic uptake of ...
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Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome
... neoplasms, organic anion transporters, tumor markers, immunohistochemistry Introduction Colorectal cancer is a global public health problem, annually accounting for over 1 million new cases of cancer and ...
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Study on the Expression of Organic Anion Transporting Polypeptide (oatp2a1) in Rat with Spleen Deficiency Syndrome and the Exploration of Clinical Significance
... rat with spleen deficiency syndrome was down-regulated compared to normal group, the expression of oatp2a1 mRNA in intestinal tissue in normal + AA group was down-regulated compared to normal group, while there was no ...
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The Effect of Cangfudaotan Tang on Expression of Organic Anion Transporting Polypeptide (oatp4a1) in Rat Ovary and Uterus Tissues of Obese PCOS
... that Organic Anion Transporting Polypeptide might be the material basis involved in transportation and transformation of ...ganic Anion Transporting Polypeptide is correlated with obese ...
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Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
... In general, the fact that genetic variation in SLCO1A/1B genes is associated with increased levels of UCB (in addition to conjugated bilirubin) might point to possible species diffe[r] ...
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Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers
... Yuchen Sun 1 , Tomomi Furihata 1* , Seiya Ishii 1 , Miki Nagai 1 , Manami Harada 1 , Osamu Shimozato 2 , Takehiko Kamijo 2 , Shinichiro Motohashi 3 , Ichiro Yoshino 4 , Atsuko Kamiichi 1 , Kaoru Kobayashi 1 and Kan Chiba ...
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Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats
... example, organic anion transporter 3 (Oat3) expression in the kidney was shown to be elevated in male mice, upregulated following castration, and downregulated in response to testosterone treatment ...
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