Organic Cation Transporter
Original Article Organic cation transporter 2 and tumor budding as independent prognostic factors in metastatic colorectal cancer patients treated with oxaliplatin-based chemotherapy
... Abstract: Oxaliplatin is currently approved for patients with metastatic colorectal cancer (mCRC). Its uptake and con- sequent cytotoxicity is determined by the levels of organic cation transporter 2 ...
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calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues
... an organic cation transporter expressed in embryonic and imaginal tissues The LP1-Gal4 line was found in an enhancer trap screen performed in the adult fly (Calleja et ...
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Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation
... Background: This paper documents a retrospective pilot study of a novel approach for treating attention deficit hyperactivity disorder (ADHD) with amino acid precursors of serotonin and dopamine in conjunction with ...
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
... diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein ...
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DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
... family. Organic cation transporters (OCTs) are involved in the transport of a variety of endo- genous and exogenous organic cationic compounds ...
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Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
... A selection pressure for the loss of OCT1 activity may exist for example if loss of OCT1 activity protects the liver from toxic organic cations. An interesting example is the case of monocrotaline, a pyrrolizidine ...
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Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane
... tions. The transport of ions and solutes across the tono- plast is a rapid way to adjust and maintain the required concentrations in the cytoplasm and to avoid the accumu- lation of toxic substances or ion concentrations ...
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Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury
... To investigate the change in expression of MATE1/ SLC47A1, human proximal tubular epithelial cells were incubated for 24 hours in serum-free renal epithelial cell [r] ...
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Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
... Background: Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse ...
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Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol
... The precise molecular mechanisms underlying met- formin’s action are not well understood. It was initially suggested that one of the key actions of metformin is to activate AMP-activated protein kinase (AMPK) through a ...
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Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide
... overexpressing organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypep- tide 1B1 (OATP1B1), OATP1B3, organic cation transporter 1 (OCT1), OCT2, ...
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Pharmacogenetics of metformin response: a step in the path toward personalized medicine
... in organic cation transporter 1 (OCT1) affects the response to the widely used biguanide metformin (see the related article beginning on page ...
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Speciation of Nickel, Lead and Cadmium under Different Soil Land Uses of Lesser Himalayas
... oxide, organic and ...by organic and carbonate, Pb with carbonate bound followed by organic and oxide, Cd with oxide followed by residual ...pH, organic carbon and calcium carbonate content ...
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Polymorphic variants of SLCO1B1 in neonatal hyperbilirubinemia in China
... basolateral (sinusoidal) membrane of human hepato- cytes, encoded by the gene of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) [4]. At this point, OATP1B1 is conjugated with ...
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Synthesis and Thermal Studies of Polyaniline Stannic Silicate and Its Role in the Removal of Toxic Metal Ions
... of organic-inorganic composite cation exchange material, a number of samples of organic-inorganic electrically con- ducting composite polyaniline stannic silicate providing a new class of hybrid ion ...
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Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
... identified organic cation transporters to those in rat BBB model cells, hCMEC/D3 cells should be a good in vitro model for further studies on the H + /OC ...acid transporter B 0,+ (SLC6A14) is ...
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Plant ABC transporters
... The ability of MRP to transport glutathione con- jugates and the inducibility of MRP isoforms by her- bicide safeners argues strongly for a role in herbicide metabolism. However, the application of herbicides is a recent ...
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Genome wide association study of antidepressant response: involvement of the inorganic cation transmembrane transporter activity pathway
... The only pathway that survived multiple-test correc- tion in both samples was GO:0022890 related to inorganic cation transmembrane transporter activity (Table 3). This pathway included several genes coding ...
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Review of macadamia orchard nutrition
... In organic matter rich soils, Al can be immobilised, resulting in less Al toxicity than in soil at the same pH with low organic matter (Brady and Weil ...
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Post Flooding Effect on Soil Quality in Nigeria: The Asaba, Onitsha Experience
... total organic carbon, total organic matter, total nitrogen, total phosphorus, cation exchange capacity, moisture content and metals (Cd, Pb, Cu, Mn, Ni and K) which were used as index for as- sessing ...
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