Organic cation transporter 1
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
... diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated ...
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Pharmacogenetics of metformin response: a step in the path toward personalized medicine
... in organic cation transporter 1 (OCT1) affects the response to the widely used biguanide metformin (see the related article beginning on page ...
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Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol
... The precise molecular mechanisms underlying met- formin’s action are not well understood. It was initially suggested that one of the key actions of metformin is to activate AMP-activated protein kinase (AMPK) through a ...
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Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide
... overexpressing organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypep- tide 1B1 (OATP1B1), OATP1B3, organic cation transporter 1 (OCT1), OCT2, ...
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DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
... Altered expression of OCT transporters is important for physiological processes and therapeutic responses to drugs. Indeed, many clinically important drugs (for example, metformin, cisplatin) are substrates for OCTs ...
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Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury
... Platinum agents are commonly used for the treatment of solid tumors. While these drugs play an essential role in cancer chemotherapy, the development of severe nephrotoxicity can lead to a poor prognosis. Renal injury ...
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Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case control sample sets reveals multiple ancestral specific effects
... classifi- cation criteria for gout, a superior ascertainment method [30] (although the NZ cases were ascertained by clinical examination whereas the incident ones by a self-adminis- tered questionnaire ...
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Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
... diluted 1:400, rabbit monoclonal anti-Na + /K + ATPase (EP1845Y) diluted 1:200, or rabbit polyclonal anti-Calnexin (ab22595; both obtained from Abcam, Cambridge, UK) diluted ...After 1 h incubation ...
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Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane
... tions. The transport of ions and solutes across the tono- plast is a rapid way to adjust and maintain the required concentrations in the cytoplasm and to avoid the accumu- lation of toxic substances or ion concentrations ...
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calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues
... Discs were dissected in PBS and fixed in 4% paraformaldehyde for 20 min at room temperature. They were subsequently washed in PBS, blocked in blocking buffer (PBS, 0.3% Triton, 1% BSA), and incubated overnight ...
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Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation
... There is variance identified and reported in children who were and were not taking drugs during this study. Future studies need to be designed to address the impact of amino acids on subgroups such as this. A further ...
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Original Article Organic cation transporter 2 and tumor budding as independent prognostic factors in metastatic colorectal cancer patients treated with oxaliplatin-based chemotherapy
... bination therapies. One candidate predictive factor is the excision repair cross-complemen- tation group 1 (ERCC1), a key protein that repairs DNA adducts induced by platinum com- pounds. Indeed, a large number of ...
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Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
... Import and export of PG and cycloguanil (CG) was assessed by single and double transduced HEK293 cells. In short, HEK293 cells seeded in 24-wells plates as described, were transduced separately with eYFP, OCT1, OCT2, ...
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Plant ABC transporters
... antigen transporter (TAP) and the Dro- sophila white and brown gene products each consist of an ATP binding domain fused to a hydrophobic domain; these `half-size' transporters are believed to function as dimers ...
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Effects of galacto-oligosaccharides on growth and gut function of newborn suckling piglets
... A good mechanical barrier can effectively prevent bacteria, endotoxins, and other harmful substances from penetrating the intestinal mucosa, and in terms of infrastructure, it functions as a tight junction be- tween the ...
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The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis
... at 1 and 2 dpf, pos- sibly due to the occurrence of pept1a ( slc15a1a ) mRNA in the maternal RNA pool, significantly de- crease at 3 ...at 1 dpf and then increasing to more than 5 × 10 5 -fold at 7 ...the ...
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The tris(malonato)chromate(III) anion with an organic cation
... and potassium hydroxide in water (molar ratio 1:2:1) on a steam bath. The resulting purple solution was mixed with an aqueous solution of malonic acid and an ethanolic solution of bpe in a 1:1 ...
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Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
... In vitro, the barrier function in brain endothelial cells is promoted by astroglia cocultures. Coculture BBB models were set up with hiPSC-derived astroglia and hiPSC-derived brain endothelial cells (r-iBECs). Bar- rier ...
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Synthesis and Thermal Studies of Polyaniline Stannic Silicate and Its Role in the Removal of Toxic Metal Ions
... the organic ion exchangers have a wide applicability but a few limitations of the organic resins have been ...the organic resins is their poor thermal stability. Since organic ion exchangers ...
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Polymorphic variants of SLCO1B1 in neonatal hyperbilirubinemia in China
... The polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was applied to detect three known variant sites (nucleotides 388, 463 and 521) of the SLCO1B1 gene. The natural or muta- genic ...
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