Organic cation transporter 2
Original Article Organic cation transporter 2 and tumor budding as independent prognostic factors in metastatic colorectal cancer patients treated with oxaliplatin-based chemotherapy
... We evaluated the correlation of OCT2 and TB levels with clinicopathological findings (Table 1). High OCT2 levels were significantly associ- ated with depth of invasion (more frequently in tumors with serosal invasion, ...
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Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
... Fig. 2 Non-synonymous OCT1 polymorphisms causing potentially functional amino acid substitutions, and their distribution in different world regions. a The localization of the 21 polymorphisms analyzed in details ...
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DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
... family. Organic cation transporters (OCTs) are involved in the transport of a variety of endo- genous and exogenous organic cationic compounds ...
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Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation
... There has been no previous peer-reviewed literature published addressing the efficacy of amino acid precursors of serotonin and dopamine simultaneously administered in the treatment of ADHD. The immediate amino acid ...
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Pharmacogenetics of metformin response: a step in the path toward personalized medicine
... Type 2 diabetes mellitus affects ...in organic cation transporter 1 (OCT1) affects the response to the widely used biguanide metformin (see the related article beginning on page ...
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Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol
... Type 2 diabetes a chronic degenerative metabolic disease represents a major medical and public health ...studied transporter regarding the impact of genetic variation on metformin action has been ...
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Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide
... overexpressing organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypep- tide 1B1 (OATP1B1), OATP1B3, organic cation transporter 1 (OCT1), OCT2, ...
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Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case control sample sets reveals multiple ancestral specific effects
... classifi- cation criteria for gout, a superior ascertainment method [30] (although the NZ cases were ascertained by clinical examination whereas the incident ones by a self-adminis- tered questionnaire ...
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Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
... AMO (10 mM), ASP (1 mM), CQ (10 mM), PQ (10 mM) and PG (10 mM) were dissolved in MilliQ water. ART (10 mM), ATO (10 mM), DHA (10 mM), LUM (10 mM), MQ (10 mM), NMQ (20 mM), PYR (10 mM), QN (10 mM) were dissolved in DMSO. ...
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
... type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of ...
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Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane
... Arabidopsis thaliana L. ecotype Col-0 was either grown in axenic culture on MS medium [17] supplemented with 2% sucrose or cultured in soil in the greenhouse. Arabi- dopsis plants were transformed using ...
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Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
... identified organic cation transporters to those in rat BBB model cells, hCMEC/D3 cells should be a good in vitro model for further studies on the H + /OC ...acid transporter B 0,+ (SLC6A14) is ...
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Synthesis and Thermal Studies of Polyaniline Stannic Silicate and Its Role in the Removal of Toxic Metal Ions
... The TGA analysis curve (Figure 1) of the material showed continuous weight loss up to 150˚C, which may be due to the removal of external water molecule and a slow weight loss up to 200˚C was observed for the re- moval of ...
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Transport of bile acids in hepatic and non hepatic tissues
... carrier is unknown. Most recently, an alternatively spliced truncated form of Asbt (t-Asbt) was isolated from a rat cholangiocyte cDNA library, and its expression has also been confirmed in rat ileum (Lazaridis et al., ...
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The tris(malonato)chromate(III) anion with an organic cation
... C14A 0.0188 (14) 0.0120 (14) 0.0233 (14) 0.0001 (11) 0.0077 (11) −0.0004 (11) N1B 0.0294 (14) 0.0095 (12) 0.0263 (13) −0.0010 (10) 0.0094 (11) −0.0011 (10) C2B 0.0212 (14) 0.0163 (14) 0.0178 (13) −0.0036 (12) 0.0038 (11) ...
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NHEVNAT: an H+ V ATPase electrically coupled to a Na+:nutrient amino acid transporter (NAT) forms an Na+/H+ exchanger (NHE)
... with transporter-specific antibodies in mosquito larval alimentary canal (Okech et ...a transporter between apical and basal membranes was identified in posterior and anterior epithelial domains ...
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Polymorphic variants of SLCO1B1 in neonatal hyperbilirubinemia in China
... The polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was applied to detect three known variant sites (nucleotides 388, 463 and 521) of the SLCO1B1 gene. The natural or muta- genic ...
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ASSOCIATION OF OCT1 GENE POLYMORPHISM WITH GLYCEMIC STATUS AND SERUM METFORMIN LEVELS IN TYPE II DIABETES MELLITUS PATIENTS
... HbA1c is a standard test for the measure of glycemic status in diabetic patients. As the blood level increases, HbA1c levels also increase. i.e, It directly correlates with the glycemic control of the patient for the ...
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Effects of galacto-oligosaccharides on growth and gut function of newborn suckling piglets
... maternal differences. GOS-90S was obtained from Quantum Hi-Tech Biological Co., Ltd. (China), which con- tained oligosaccharides with a degree of polymerization (DP) of 2–8 with approximately 90% (w/w) GOS, 8.5% ...
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Speciation of Nickel, Lead and Cadmium under Different Soil Land Uses of Lesser Himalayas
... of organic matter ...Soil organic matter was variable, ranging between ...of organic carbon found in the forest soils ...The cation exchange capacity varied between ...
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