Orphan nuclear receptor
Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells
... The orphan nuclear receptor NR0B1 is highly conserved in evolution from fish to mammals ...estrogen receptor β (ERβ), all of which are essential transcription factors for ES cell self-renewal ...
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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
... (h) orphan nuclear receptor, termed the pregnane X receptor (PXR), that binds to a response element in the CYP3A4 promoter and is activated by a range of drugs known to induce CYP3A4 ...
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Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
... The orphan nuclear receptor 4A2 (NR4A2/NURR1, nuclear receptor related-1) has recently emerged as a novel transcription factor with regulatory roles in in- flammatory arthritis ...the ...
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The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice
... the orphan nuclear receptor small het- erodimer partner (Nr0b2), which is both a target gene and a transcriptional repressor of estrogen receptors, controls testicular function by regulating germ ...
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Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4
... We have used apolipoprotein genes to investigate the signal transduction mechanisms involved in the control of intestinal specific gene expression. The human apoAI, apoCIII, and apoAIV genes are tandemly organized within ...
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The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo
... The results reported here implicate EAR-2 as a player not only in self-renewal of normal HSCs but also as an MDS oncogene. These findings have important practical implications. Nuclear receptors are eminently “ ...
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Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells
... of nuclear receptors represents a good example of the step-by-step detection of further levels of ...The nuclear receptor proteins purified first could be described as transcriptional activators ...
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The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice
... leptin receptor - deficient), KKA y mice and Zucker fatty rats ...the nuclear hor- mone receptor peroxisome proliferator-activated re- ceptor γ (PPARγ) and their antidiabetic actions are believed to ...
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Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis
... the nuclear localization segment (NLS) of TR3 is in the DNA binding domain [16], our results clearly indicate that TR3(S351A), TR3(S351D) and Nur77∆GRR are detected in nuclei (Figure ...
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Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions
... arylhydrocarbon receptor; AICD, activation induced cell death; AP-1, activating protein-1; Bcl6, B-cell lymph- oma 6 protein; BMAL1/ARNTL, aryl hydrocarbon receptor nuclear translocator-like; C/EBP α ...
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Microcantilever based Nanomechanical Studies of the Orphan Nuclear Receptor Pregnane X Receptor Ligand Interactions
... Figure 2 compares the responses of a PXR functional- ized MC when exposed to three analytes in PBS. This figure illustrates that 1.0 M rifampicin is the most po- tent PXR activator in this group. Our experiments in the ...
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Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells
... An increasing number of studies have implied that ApoM may play a critical role in the process of bile acid metabo- lism. It has been demonstrated that ApoM expression can be regulated by some nuclear receptors ...
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The Divergent Orphan Nuclear Receptor ODR-7 Regulates Olfactory Neuron Gene Expression via Multiple Mechanisms in Caenorhabditis elegans
... Willson, T. M., and S. A. Kliewer, 2002 PXR, CAR and drug metab- Zechel, C., X. Q. Shen, P. Chambon and H. Gronemeyer, 1994 olism. Nat. Rev. Drug Disc. 1: 259–266. Dimerization interfaces formed between the DNA binding ...
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Clinical and functional effects of mutations in the DAX-1 gene in patients with adrenal hypoplasia congenita
... the nuclear hormone receptor superfamily (12, 14, ...an orphan nuclear receptor because no specific ligand has been identified to date ...
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Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein
... The yeast two-hybrid analysis indicated an interaction between orphan nuclear receptor NR4A1 and human papillomavirus type 16 E2 regulatory protein. S. cerevisiae MaV203 cells transfromed with ...
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COUP TFI controls activity dependent tyrosine hydroxylase expression in adult dopaminergic olfactory bulb interneurons
... As for other OB interneurons, the generation of DAergic cells initiates during embryonic ages and continues throughout life from spatially restricted pools of stem/progenitor cells (Luskin, 1993; De Marchis et al., 2007; ...
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Ederle, Helena (2018): Identification of the nuclear export pathways of TDP‐43 and FUS. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)
... in nuclear export and neuronal diseases came from work on nucleoporin GLE1, a key component of the mRNA export ...deplete nuclear pore complexes of the GLE1 protein in HeLa ...
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Retinoic acid receptors and nuclear orphan receptors in the development of Xenopus laevis
... Int J Dev lliol 40 255 262 (\ 9%) 255 Retinoic acid receptors and nuclear orphan receptors in the development of Xenopus laevis CHRISTINE DREYER* and HEIDRUN ELLINGER ZIEGELBAUER' Max Planck Institut[.] ...
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Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
... 18. Shabani M, Asgarian Omran H, Farsangi MH, Vossough P, Sharifian RA, Toughe GR, et al. Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid ...
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Involvement of α6β4integrin in the mechanisms that regulate breast cancer progression
... as c-met (a hepatocyte growth factor receptor) to promote invasion [40]. Stimulation with hepatocyte growth factor (c-met kinase) transphosphorylates β 4 , which associates with Shc and PI3K, potentiating ...
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