Oseltamivir resistance
Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro
... of oseltamivir resistance in seasonal H1N1 isolates from 2007 to 2009 ...of resistance with little imped- iment at the genomewide or population ...other resistance mutations in the ...
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Highly Sensitive and Quantitative Detection of the H274Y Oseltamivir Resistance Mutation in Seasonal A/H1N1 Influenza Virus
... showing resistance to oseltamivir (13, ...reported oseltamivir-resistant influenza viruses ...no oseltamivir resistance in Europe ...showed resistance (4). In addition, dur- ing ...
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Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS)
... with oseltamivir (within 48 hours of symptom onset) and vs treated patient with a resistant ...developed resistance during the study plus 9 patients infected with seasonal ...developed oseltamivir ...
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Identification of Oseltamivir Resistance among Pandemic and Seasonal Influenza A (H1N1) Viruses by an His275Tyr Genotyping Assay Using the Cycling Probe Method
... confers resistance to oseltamivir (7, 12, 21, 22, ...of oseltamivir-sensitive and -resistant isolates with H275 and H275Y in NA gene of influenza A (H1N1) ...virus. Oseltamivir- sensitive and ...
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NA segment to detect Oseltamivir-resistance,
... analyzing Oseltamivir-resistance, the PCA features' dimensionality will be tested at 5 to 10 increment intervals, starting at 3 PCA features, so as to find the optimal number of features that enhance ...
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Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into the Mechanisms of Oseltamivir Resistance
... with resistance to the most heavily used influenza drug, ...H274Y resistance may also be possible for some group 2 ...mild oseltamivir resistance for ...
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Development of a quadruple qRT PCR assay for simultaneous identification of highly and low pathogenic H7N9 avian influenza viruses and characterization against oseltamivir resistance
... Background: During the fifth wave of human H7N9 infections, a novel highly pathogenic (HP) H7N9 variant emerged with an insertion of multiple basic amino acids in the HA cleavage site. Moreover, a neuraminidase inhibitor ...
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Published sequences do not support transfer of oseltamivir resistance mutations from avian to human influenza A virus strains
... Discussion The present study, based on analysis of more than 19,700 complete N1 and N2 sequences in specimens from humans infected with H1N1 or H3N2 virus, shows that transfer of avian N[r] ...
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Adamantane and Oseltamivir Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009
... and oseltamivir resistance among influenza viruses is a major concern to public health ...for oseltamivir resistance by a fluorescence- based neuraminidase (NA) inhibition assay along with NA ...
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A two year survey of the oseltamivir resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir
... Background: Oseltamivir is the preferred antiviral drug for influenza, but oseltamivir-resistant A(H1N1) viruses have circulated worldwide since the 2007-2008 influenza ...of oseltamivir ...
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Influenza Antiviral Resistance Testing in New York and Wisconsin, 2006 to 2008: Methodology and Surveillance Data
... adamantane resistance, NAI resistance can de- velop as a result of amino acid-altering mutations in the NA gene of influenza ...NAI resistance muta- tions, distributed throughout the NA gene, result ...
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Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor
... multidrug resistance with enhanced resistance to oseltamivir (27, ...shows oseltamivir resistance ...severe oseltamivir resistance and a milder effect for ...
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Efficacy of oseltamivir peramivir combination therapy compared to oseltamivir monotherapy for Influenza A (H7N9) infection: a retrospective study
... the oseltamivir monotherapy group (39 patients, ...the oseltamivir-peramivir combination group were enrolled in the second H7N9 ...The oseltamivir- resistance is more likely to emerge in ...
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Understanding the cross-resistance of oseltamivir to H1N1 and H5N1 influenza A neuraminidase mutations using multidimensional computational analyses
... of resistance of oseltamivir in H1N1 and ...of resistance is entirely dependent on the type of mutation, relative positioning of such occurrences, and the repercus- sions thereof on the active site ...
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Oseltamivir in pregnancy and birth outcomes
... of oseltamivir or other NAIs [8, ...to oseltamivir during the H1N1 pandemic, re- ported no evidence of an association between prenatal exposure to oseltamivir and preterm birth, low Apgar scores, or ...
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Influenza treatment and prophylaxis with neuraminidase inhibitors: a review
... to oseltamivir and prolonged ...of oseltamivir-resistant strains may be slightly less efficient than that of the wild-type virus, but resistant strain viral titers tend to be comparable to that of the ...
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Determination of Oseltamivir Phosphate in Capsules by Visible Spectrophotometry
... of Oseltamivir Phosphate in pure as well as capsule dosage ...Because Oseltamivir Phosphate (Figure 1) possesses amine group, the protonated form may act as cationic site for anionic dye such as Bromophenol ...
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Evaluation of Influenza A H1N1 infection and antiviral utilization in a tertiary care hospital
... A matched (1:1) case-control study was performed to analyze the factors associated with infection and in-hospital mortality, comparing patients who would have similar ill- ness severity during hospitalization and thus ...
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Prescription of antiviral drugs during the 2009 influenza pandemic: an observational study using electronic medical files of general practitioners in the Netherlands
... In conclusion, this study showed that general practitioners in the Netherlands have been very restrained in prescribing antiviral drugs during the influenza pandemic. Where GPs have used antiviral medication, they have ...
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Formulation and Evaluation of Oseltamivir Phosphate Capsules.
... prodrug oseltamivir phosphate 1 (Tamiflu) and its enantiomer ent-1 starting from cheap, commercially available 2,6-dimethoxyphenol 10 is ...gave oseltamivir phosphate 1 in a total of 10 steps and an overall ...
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