Oseltamivir resistant
Genetic Makeup of Amantadine Resistant and Oseltamivir Resistant Human Influenza A/H1N1 Viruses
... of oseltamivir-susceptible subclade 2B viruses, as re- vealed by the close clustering of these viruses in the phylog- enies of the eight segments, by acquiring the H275Y resistance-conferring mutation in ...
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Spread of Influenza A(H1N1) oseltamivir resistant viruses in Africa in 2008 confirmed by multiple introductions in Senegal
... between oseltamivir-sensitive and oseltamivir-resistant influenza A(H1N1) ...from oseltamivir-sensitive A(H1N1) viruses (predicted size of the major digest pro- duct: 147 ...). ...
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Characteristics of oseltamivir resistant influenza A (H1N1) pdm09 virus during the 2013–2014 influenza season in Mainland China
... H1N1pdm09 viruses isolated from specimens collected from September 1, 2013 through March 31, 2014 were obtained from the Chinese National Influenza Surveil- lance Network, which covers 32 provinces in mainland China ...
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Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets
... the oseltamivir- resistant H275Y ...of oseltamivir-resistant A(H1N1)pdm09 strains in the absence of antiviral treatment also justify this ...of oseltamivir resistance cases were not ...
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Adamantane and Oseltamivir Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009
... and oseltamivir resistance among influenza viruses is a major concern to public health ...for oseltamivir resistance by a fluorescence- based neuraminidase (NA) inhibition assay along with NA gene ...by ...
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Oseltamivir-Resistant Influenza A Viruses Are Transmitted Efficiently among Guinea Pigs by Direct Contact but Not by Aerosol
... inhibitors oseltamivir and ...in oseltamivir-resistant influenza A/H1N1 viruses, predominantly in the northern ...to oseltamivir; in the in- fluenza season of 2007 to 2008, 15% of global H1N1 ...
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Comparable Fitness and Transmissibility between Oseltamivir-Resistant Pandemic 2009 and Seasonal H1N1 Influenza Viruses with the H275Y Neuraminidase Mutation
... after oseltamivir treatment (10, ...an oseltamivir-resistant variant over the sensitive H1N1 ...to oseltamivir usage, suggesting that the transmissibility of the H275Y variant was at least ...
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Circulation of human influenza viruses and emergence of Oseltamivir resistant A(H1N1) viruses in Cameroon, Central Africa
... This study confirmed the circulation of human influenza A(H1N1), A(H3N2) and B viruses in Central Africa and documented the emergence of oseltamivir-resistant H1N1 viruses in Cameroon. Moreover, influenza ...
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Assessing the Viral Fitness of Oseltamivir-Resistant Influenza Viruses in Ferrets, Using a Competitive-Mixtures Model
... that resistant virus variants with the same NA mutation may differ in replication or transmission fitness depending on other viral ...other resistant mutants, it was believed that NAI-resistant ...
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Oseltamivir-Resistant Variants of the 2009 Pandemic H1N1 Influenza A Virus Are Not Attenuated in the Guinea Pig and Ferret Transmission Models
... amantadine/rimantadine resistant, making them of great public health concern ...the resistant novel H1N1 viruses were iso- lated from patients refractory to oseltamivir treatment, and 44% of the ...
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Enhanced Mammalian Transmissibility of Seasonal Influenza A/H1N1 Viruses Encoding an Oseltamivir-Resistant Neuraminidase
... by oseltamivir-resistant Bris- bane/59-like sH1N1 ...these oseltamivir-resistant Brisbane/ 59-like ...the oseltamivir-resistant clade 2B-2 NA (which is characterized by the H275Y ...
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Amino Acid Changes in Hemagglutinin Contribute to the Replication of Oseltamivir-Resistant H1N1 Influenza Viruses
... to oseltamivir but attenuates virus growth in vivo and in vitro (1, 4, 6, 14, ...the oseltamivir-resistant viruses that circulated in 2007 and 2008 were similar to those of sensitive viruses ...
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A two year survey of the oseltamivir resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir
... respectively. Oseltamivir-resis- tant isolates from Yamagata in the 2007-2008 season might have acquired resistance through the use of osel- ...2008-2009 oseltamivir-resistant isolates from Yamagata ...
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Nosocomial outbreak of the pandemic Influenza A (H1N1) 2009 in critical hematologic patients during seasonal influenza 2010 2011: detection of oseltamivir resistant variant viruses
... as oseltamivir (Tamiflu TM) and zanamivir (Relenza TM) that have been used extensively for chemoprophylaxis and treatment in 2009 pandemic ...of oseltamivir-resistant (OST-r) pandemic H1N1pdm09 ...
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Efficacy of oseltamivir peramivir combination therapy compared to oseltamivir monotherapy for Influenza A (H7N9) infection: a retrospective study
... the oseltamivir monotherapy group (39 patients, ...the oseltamivir-peramivir combination group were enrolled in the second H7N9 ...The oseltamivir- resistance is more likely to emerge in severe cases ...
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Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses
... by oseltamivir in the NI assay (32, ...with oseltamivir 5 days after the first ...higher oseltamivir dose appeared to increase the emergence of this variant NA, a finding consistent with a previous ...
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Competitive Fitness of Oseltamivir-Sensitive and -Resistant Highly Pathogenic H5N1 Influenza Viruses in a Ferret Model
... to oseltamivir and zanamivir (12, 24, 26, 35) or were linked to reduced drug susceptibility in avian and human viruses carrying N1 NA ...with oseltamivir resistance (12, 35) and the NA mutations V116I, ...
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Oseltamivir Is Effective against 1918 Influenza Virus Infection of Macaques but Vulnerable to Escape
... 23). Oseltamivir phosphate had previously shown efficacy in mice against infection with recombinant viruses bearing the 1918 influenza HA, NA, and M gene segments (7), but evaluation against the fully reconstructed ...
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NA segment to detect Oseltamivir-resistance,
... detecting Oseltamivir-resistance, when using PCA features, by comparing the performance of neural networks (NNs) & decision trees (DTs) (c) Comparing findings to previous experiments conducted on detecting ...
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Selection for resistance to oseltamivir in seasonal and pandemic H1N1 influenza and widespread co-circulation of the lineages
... are resistant to oseltamivir, initially, pandemic H1N1 strains have been susceptible to ...to oseltamivir in 225 cases of H1N1 pandemic ...to oseltamivir in pandemic H1N1 could be due to point ...
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