Osteochondral Defect
Effects of osteochondral defect size on cartilage regeneration using a double network hydrogel
... animal osteochondral defect models ...repair osteochondral defects by using the ar- tificially synthesized hydrogel without any cultured cells or mammalian-derived ...the defect size, it would ...
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Influence of the gel thickness on in vivo hyaline cartilage regeneration induced by double network gel implanted at the bottom of a large osteochondral defect: Short term results
... the defect so that a 2- to 3-mm deep vacant space was left in the defect, the evaluation scores were found to be the ...large osteochondral defect, at least, in a range between ...
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Spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect created in the femoral condyle using a novel double network hydrogel
... an osteochondral defect by creating many thin holes that penetrate the subchondral bone at the base of the defect in order to create bleeding from the bone marrow and subsequent clot formation ...
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Unravelling the Role of Mechanical Stimuli in Regulating Cell Fate During Osteochondral Defect Repair
... In a previous study we developed a computational mechanobiological model which predicted cell fate during the spontaneous repair process within an osteochondral defect. While this model successfully ...
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Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5 year follow up
... large osteochondral defects of the human ...of osteochondral de- fect of the human knee [16, ...an osteochondral defect was promoted by implantation of autologous bone marrow (BM)-MSCs ...
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Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair
... for osteochondral defect repair will have depth-dependant mechanical properties, with a Young’s modulus that reduces in magnitude and a permeability that increases in magnitude from the superficial zone ...
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A Computational Model of Osteochondral Defect Repair Following Implantation of Stem Cell Laden Multiphase Scaffolds
... of osteochondral defects ...an osteochondral defect must be resistant to terminal differentiation in order to prevent the upward migration of the bone plate (10), a phenomena which has been ...
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rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model
... culture, osteochondral defect cultures) were washed twice and maintained for 24 h in serum-free medium previously to the collection of the culture medium ...
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The effect of autologous adipose derived mesenchymal stem cell therapy in the treatment of a large osteochondral defect of the knee following unsuccessful surgical intervention of osteochondritis dissecans – a case study
... with the previous area of OCD (Fig. 1). MRI showed marked abnormality over the weight bearing portion of the medial femoral condyle measuring 2.3 cm × 1.5 cm. The subchondral cyst had successfully been debrided and ...
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Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration
... the defect was covered with fibrous tissue instead of hyaline cartilage in the control group ...the defect regions. In the ECM/GelMA/exosome group, however, the defect area was regenerated with a ...
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Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model
... failure and scaffold engraftment by understanding MRI signal characteristics relating to particular events and have also demonstrated evidence of engraftment of stem cells to the defect site by MRI [14]. In our ...
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Clinical results of multilayered biomaterials for osteochondral regeneration
... multifocal osteochondral de- fects of the medial femoral condyle, trochlea and patella, and concurrently by restoring the correct alignment of a varus knee through a closing-wedge high tibial ...plateau ...
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3D Bioprinting for Cartilage and Osteochondral Tissue Engineering
... MSCs were combined with atelocollagen and BMP-2 in the bone region, and hyaluronic acid and TGF-β3 in the cartilage region. The construct was reinforced using a PCL frame and demonstrated heterogeneous tissue development ...
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Differences in joint morphology between the knee and ankle affect the repair of osteochondral defects in a rabbit model
... There are a few limitations to this study. First, this research did not consider sufficiently the influence of weight bearing. Takahashi et al. reported that loading and unloading in the early phase of cartilage repair ...
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Characterization of a novel polyvinyl alcohol/chitosan porous hydrogel combined with bone marrow mesenchymal stem cells and its application in articular cartilage repair
... performed randomly at the patellar groove of one hind limb of each rabbit. The surgical procedures employed have been reported before [22]. Under general anesthesia, shaving, disinfection, and draping were briefly ...
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The role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects
... an osteochondral defect, the mechanical environment also has a direct influ- ence on tissue formation by affecting the quality of the cartilage tissue as well as the course of endo- chondral ...
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Fabella Syndrome: A Typical Case of Misdiagnosis and Discussion
... DOI: 10.4236/crcm.2019.89032 267 Case Reports in Clinical Medicine often miss diagnosed in radiography [28]. Moreover, its variable size and nature (bone, cartilage, or mixed) [18] [19] may lead to confusion in the ...
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Histological and Gross Evaluation through Second-Look Arthroscopy of Osteochondral Lesions of the Talus after Failed Treatment with Particulated Juvenile Cartilage: A Case Series
... an osteochondral defect of the talus that was initially treated with ankle arthroscopy with debridement and microfracture of the ...for osteochondral allograft transfer and lateral ankle ligament ...
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Mechano regulation of stem cell differentiation and tissue regeneration in osteochondral defects
... each defect, and attributed some of this variability to the fact that defects were created in various places over the articular surface and hence subject to different mechanical ...an osteochondral ...
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Mechanobiological models of Skeletal Tissue Differentiation
... Mechanical forces may act within tissues at the cellular level to regulate biological processes, a field of study that has been termed mechanobiology. The aim of computational mechanobiology is to derive sets of ...
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