Osteochondral defects
Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats
... engineered tissue with biphase synthetic for osteochondral repair has become one of the hot research fields [6]. Vari- ous advanced scaffolds have been preclinically applied in osteochondral defects ...
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Mechano regulation of stem cell differentiation and tissue regeneration in osteochondral defects
... cartilage defects would be that it provides a sufficiently rigid environment to maintain a viable cell population at the articular surface, with the hope of preventing fibrous tissue formation in this ...
29
In vitro and in vivo studies of a novel bacterial cellulose-based acellular bilayer nanocomposite scaffold for the repair of osteochondral defects
... of osteochondral defects (OCD), we developed and characterized novel BC-based nanocomposite scaffolds, for example, BC-hydroxyapatite (BC-HA) and BC-glycosaminoglycans (BC-GAG) that mimic bone and ...
23
The effect of sodium hyaluronate–chondroitin sulfate combined solution on cartilage formation in osteochondral defects of the rabbit knee: an experimental study
... articular single mesenchymal stem cell injection had a very effective role in the healing of osteochondral defects. In our study, there was significant articular cartilage formation of hyaline and/or ...
10
Pulsed electromagnetic fields after arthroscopic treatment for osteochondral defects of the talus: double blind randomized controlled multicenter trial
... Osteochondral defects (ODs) of the talus often have a severe impact on the quality of life of the patients. The patients are usually young and athletic; most are male (62%) in the third decade of their ...
10
Hyaline Cartilage Regeneration on Osteochondral Defects by Intraarticular Injection of Human Peripheral Blood CD34+ Stem Cells, Hyaluronic Acid and Growth Factor In a Rat Model
... Until now, there is still no satisfying treatment method in repairing cartilage damage that producing hyaline cartilage, both conservative and surgical therapy. Conservative therapy including drugs administration, ...
10
Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental study
... for Testing and Materials International indicate that the critical size of a chondral defect in a rabbit is 3 mm in diameter [18]. Kirschner wire was used to induce a microfracture on all defects. Consequently, 36 ...
8
Regeneration of osteochondral defects using developmentally inspired cartilaginous templates
... control defects, coupled with positive collagen type 1 staining, suggests the development of a fibrocartilaginous ...of osteochondral defects using bone marrow derived stem cells in a collagen gel ...
32
Osteochondral defects of the talus with a focus on platelet rich plasma as a potential treatment option: a review
... To a lesser degree, osteochondral lesions occur in asso- ciation with ischaemic necrosis when there is interference of the blood supply to a given portion of the talus. This is often labelled as ‘Osteochondritis ...
6
The role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects
... an osteochondral defect, the mechanical environment also has a direct influ- ence on tissue formation by affecting the quality of the cartilage tissue as well as the course of endo- chondral ...
16
Biological and functional evaluation of a novel pyrolytic carbon implant for the treatment of focal osteochondral defects in the medial femoral condyle: assessment in a canine model
... All animals underwent bilateral implantation of the de- vices in the medial femoral condyle (pyrolytic carbon in one knee and Co-Cr alloy in the other, Fig. 2). Under ster- ile conditions, the medial capsule of the knee ...
12
Autologous stem cell-derived chondrocyte implantation with bio-targeted microspheres for the treatment of osteochondral defects
... autograft transfer system (OATS), osteochondral allo- grafts, and autologous chondrocyte implantation. Each treatment has advantages and disadvantages. Bone mar- row stimulation techniques, such as microfracture, ...
13
Differences in joint morphology between the knee and ankle affect the repair of osteochondral defects in a rabbit model
... There are a few limitations to this study. First, this research did not consider sufficiently the influence of weight bearing. Takahashi et al. reported that loading and unloading in the early phase of cartilage repair ...
10
Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study
... Exogenous fibrin clots have been used to facilitate healing in canine and equine knee joints [15-17]. Such clots might promote faster and more organized repair of osteochondral defects. Hyperbaric oxygen ...
9
A Computational Model of Osteochondral Defect Repair Following Implantation of Stem Cell Laden Multiphase Scaffolds
... of osteochondral defects ...an osteochondral defect must be resistant to terminal differentiation in order to prevent the upward migration of the bone plate (10), a phenomena which has been ...
29
Tissue specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues
... of osteochondral defects with control scaffolds or bi-layered AC-GP scaffolds after 6 and 12 months, respectively, and b) quantification of the macroscopic appearance of the defects based on repair ...
62
Principles of cartilage tissue engineering in TMJ reconstruction
... or osteochondral tissue (mosaicplasty), routinely used in orthopaedic joint and bone surgery but seldom applied in the TMJ region [4], is aimed to repair mid-size chondral or osteochondral ...
7
3D Bioprinting for Cartilage and Osteochondral Tissue Engineering
... The majority of TE studies to date have focused on treating focal cartilage and osteochondral defects. However diseases such as OA effect the entire joint surface. A number of studies have explored using ...
65
Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo.
... surface defects account for up to 60% of total knee arthroscopies performed in the United States [1, ...joint defects are a clear risk factor for the development of osteoarthritis (OA) when left un- treated ...
13
Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis
... an osteochondral tissue construct is a unique feature of our system and is based on the results of numerous studies describing the important role ECs play in regulating bone biology ...
6