Otic placode
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
... the otic placode, but does not eliminate it entirely. The otic placode also forms in mice lacking other crucial components of the Notch pathway, such as Pofut1 or Rbpj/Rbsuh/CSL (Oka et ...the ...
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A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue specific paralogs
... The otic placode, a specialized region of ectoderm, gives rise to components of the inner ear and shares many characteristics with the neural crest, including expression of the key transcription factor ...
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The first steps towards hearing: mechanisms of otic placode induction
... presumptive otic ectoderm (Hume and Dodd, 1993, Bouillet et ...presumptive otic ectoderm is exposed to Wnt ...a placode- epidermis fate decision, β -catenin, a downstream molecule neces- sary for ...
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Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm
... the otic placode ...The otic epithelium appeared enlarged and failed to close ...the otic placode resulted in a flat or opened otic pit (29/42) rather than closed otic ...
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Wnt signals mediate a fate decision between otic placode and epidermis
... the otic placode and its ...early otic markers such as Pax8 and Dlx5, and an expansion of epidermal markers such as ...early otic markers, and concomitant loss of epidermal ...interconnected ...
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Competence of cranial ectoderm to respond to Fgf signaling suggests a two step model of otic placode induction
... an otic placode when grafted adjacent to the posterior hindbrain (Groves and Bronner-Fraser, ...express otic placode markers in the presence of Fgf2, while other populations of competent ...
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Fgf and Hh signalling act on a symmetrical pre pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle
... the otic rudiment with respect to the hindbrain rhombomeres alters over time in the zebrafish embryo, consistent with the proposed sequential roles of r4-derived Fgf signalling in otic induction and AP ...
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Specification of the otic placode depends on Sox9 function in Xenopus
... developing otic placode and vesicle by whole-mount in situ ...prospective otic placode that appears to be confined to the sensory layer of the ectoderm ...presumptive otic ...
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Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode
... the otic placode and pronephros in these species (Pfeffer et ...However, otic development in Pax2/Pax8-deficient mouse embryos has not yet been ...the otic placode during late ...
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Fate map of the chicken otic placode
... avian otic placode at the 10-somite stage, using the well-known chick-quail grafting model (Alvarado-Mallart and Sotelo, 1984; Le Douarin, 1969), with an experimental operating grid of 12 sectors [three ...
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Essential role for PDGF signaling in ophthalmic trigeminal placode induction
... alternative placode fates (Bailey et al., 2006). For olfactory placode, FGF from the anterior neural ridge as well as an unidentified inhibitory factor from neural crest cells is required for suppression of ...
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Exploring the developmental roles of plk4
... The expression of Plk4 during frog and mouse development has some similarities. For example, in both animals Plk4 is expressed in proliferative tissues such as the brain. Our analysis shows that plk4 expression in ...
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The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle
... Otoliths (in teleost fish) and otoconia (in mammals) are biomineralised structures that form inside the inner ear. They lie over patches of sensory hair cells, where they provide an inertial mass load for sensing gravity ...
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Changes in retinoic acid signaling alter otic patterning
... embryos, otic induction can be rescued but not ...of otic induction but that axin2 is expressed within the preotic region prior to the formation of the otic region (our unpublished ...smaller ...
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Mechanisms of cranial placode assembly
... and otic placode coalescence in ...of placode precursors accompany olfactory placode coalescence between 4s and 18s stages (Harden et ...the otic placode next ...
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Sensational placodes: Neurogenesis in the otic and olfactory systems
... The otic placode becomes subdivided into an anterior neuro- genic and posterior non-neurogenic ...the otic vesicle (Haddon and Lewis, ...the otic-epibranchial precursor ...all otic ...
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Hindbrain signals in otic regionalization: walk on the wild side
... the placode and vesicle from 14 ss (16 hpf) onwards (Adamska et ...The otic placode is pink, the neuroblasts and SAG are yellow, the sensory cristae are blue, the sensory maculae are orange and the ...
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Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
... the otic placode, the primordium of the hearing organ 20,21 ...in placode signaling have been identified as FGF3 and FGF10 22,23 , we hypothesized that exposure to these factors would trigger ...
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Sensational placodes: Neurogenesis in the otic and olfactory systems.
... The otic placode becomes subdivided into an anterior neuro- genic and posterior non-neurogenic ...the otic vesicle (Haddon and Lewis, ...the otic-epibranchial precursor ...all otic ...
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Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
... and otic placodes by the beginning of somitogenesis (Akimenko et ...of otic tissue even in the presence of functional Fgf signaling (Solomon and Fritz, 2002; Liu et ...presumptive otic ...
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