Outcomes and progression
Continuing trastuzumab beyond disease progression: outcomes analysis in patients with metastatic breast cancer
... From an efficacy perspective, we were unable to lend clear support to this 'off-label' use of trastuzumab. This is based par- ticularly on the observation that patients retaining trastuzumab for multiple chemotherapy ...
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Predicting disease progression and poor outcomes in patients with moderately active rheumatoid arthritis: a systematic review
... activity progression was typically defined us- ing standard DAS28 thresholds (remission, ...Health Outcomes Questionnaire (HAQ) to de- fine progression in ...‘other outcomes’ category included ...
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Measuring clinical progression in MCI and pre-MCI populations: enrichment and optimizing clinical outcomes over time
... measuring progression in the pre-dementia or mild cognitive impairment (MCI) stage and even pre-symptomatic or pre-MCI stage of ...clinical outcomes that are also sensitive for measuring progression ...
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Patterns, predictors and subsequent outcomes of disease progression in metastatic renal cell carcinoma patients treated with nivolumab
... Several molecular and genetic predictive biomarkers of immunotherapy are under investigation including PD-L1 expression [15], tumor mutational burden [16], gene ex- pression signatures [17] and tumor infiltrating ...
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A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model
... its progression towards ESRD, on society and public healthcare ...disease progression in alternative, real-world clinical examples similarly demonstrated significant ESRD risk over the course of a patient’s ...
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Evaluation of preoperative speed of progression and its association with surgical outcomes in primary congenital glaucoma patients: a retrospective study
... to progression of glaucoma ...rapid progression of ...the progression after presentation or surgery in order to evaluate the surgical outcome instead of regarding SP as a predictive factor of ...
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Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients
... disease progression in general, and of specific sites of metastasis, in a HER-2 negative mBC ...disease progression would be associated with a decrease in composite indicators of HRQoL and worsening of ...
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Effect of Four Approaches to Oral Feeding Progression on Clinical Outcomes in Preterm Infants
... Copyright © 2015 Rita H. Pickler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided ...
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Original Article A high expression of MTERF3 correlates with tumor progression and predicts poor outcomes in patients with brain glioma
... The expressions of the MTERF3 mRNA and protein in human noncancerous brain tissues, and high-grade and low-grade glioma tissues as detected by RT-PCR and Western blot (* P< 0.05 vs.[r] ...
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P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy
... confidence intervals were computed using univariate logistic regression models. PFS and overall survival were analyzed by the method of Kaplan and Meier. PFS while on systemic therapy before referral to the Phase I ...
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Progression of Blood Pressure and Cardiovascular Outcomes in Hypertensive Patients in a Reference Center
... study published in 2010, showed that long-standing hypertension is one of the main reasons for a reduction in life expectancy in subjects with stroke. The present study showed that such complication was more frequent ...
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Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes
... Although the new data provide clarity about Stat5a and Stat5b in breast cancer, several limitations of this study exist. The present study focused on Stat5a and Stat5b expression in normal and malignant cells, but it ...
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RE Progression. RE Progression of Skills and Knowledge Page 1
... ▪ find out about and investigate key concepts and questions of belonging, meaning, purpose and truth, responding creatively ▪ enquire into what enables different individuals and communities to live together respectfully ...
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Women’s Progression in the Workplace
... 4.4 Interventions to address conflict between work and external responsibilities International evidence suggests that a flexibility stigma is likely to affect workers making use of flexible working arrangements, with ...
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RE Skills Progression
... End Outcomes EYFS Children listen attentively in a range of situations. They listen to stories, accurately anticipating key events and respond to what they hear with relevant comments, questions or actions. They ...
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History Progression. Year 3 OUTCOMES
... Know what mummification is and can explain the process, including why it was so important for the Egyptians going to the afterlife Pupils know why and how the pyramids were built. Know[r] ...
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Flotillin 2 is associated with breast cancer progression and poor survival outcomes
... tumor-derived lung metastasis. We therefore hypothesize that FLOT2 may affect the development and progression of breast cancer through modulating certain signaling pathways, which may open new avenues into the ...
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Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes
... MMPs are regulated by different factors such as insulin resistance and obesity. Different components of the metabolic syndrome have been identified as possible stimulus for the synthesis and activity of MMPs. On the ...
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Progression of CKD form pre-dialysis : natural course, risk factors, and outcomes
... Multidisciplinary pre‐dialysis care Ideal preparation for renal replacement therapy comprises of referral to a multidisciplinary team, consisting of a nephrologist, a dietician, and a social worker. The nephrologist is ...
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Clinical course of nonalcoholic fatty liver disease: an assessment of severity, progression, and outcomes
... disease progression than patients without diabetes due to increased monitoring by health care providers; however, the present study was intended to characterize the clinical course of NAFLD in a real-world cohort ...
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