outer medullary collecting duct
Metabolic acidosis stimulates H+ secretion in the rabbit outer medullary collecting duct (inner stripe) of the kidney
... sorption) of the collecting duct segments (7). If this segment were capable of enhancing its rate of transport during meta- bolic acidosis, it could contribute greatly to the restoration of acid–base ...
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Enzymatic Activity of Renal H K ATPase in the Outer Medullary Collecting Duct of Transgenic Mice
... The outer medullary collecting duct (OMCD) plays an important role in acid-base homeostasis by mediating transepithelial bicarbonate transport and urinary ...
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Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct Functional evidence for proton potassium activated adenosine triphosphatase
... We examined the hypothesis that proton-potassium-activated adenosine triphosphatase (H- K-ATPase) mediates K absorption and acidification in the inner stripe of the outer medullary collecting ...
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Mineralocorticoid modulation of apical and basolateral membrane H+/OH /HCO3 transport processes in the rabbit inner stripe of outer medullary collecting duct
... Abstract To examine the mechanism by which mineralocorticoids regulate HCO3- absorption in the rabbit inner stripe of the outer medullary collecting duct, we microfluorometrically measur[r] ...
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Different localization and regulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction
... cortical collecting duct, cortical collecting duct, outer medullary collecting duct, inner medullary collecting duct, and arcuate ...inner ...
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Regulation of rabbit medullary collecting duct cell pH by basolateral Na+/H+ and Cl /base exchange
... The collecting duct of the inner stripe outer medulla (OMCDi) is a major site of distal nephron acidification. Using the pH sensitive fluorescent dye 2'-7'-bis(carboxyethyl)-5,6,- carboxyfluorescein ...
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Medullary collecting duct acidification Effects of potassium, HCO3 concentration, and pCO2
... The medullary collecting duct (MCD) from renal outer medulla possesses significant HCO3 absorptive capacity. In vitro microperfusion studies have shown that HCO3 absorption in this segment is ...
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Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium
... inner medullary collecting ducts (IMCDs) and the papillary surface epithelium (PSE) of the kidney, two determinants of passive transport were measured, namely permeability coefficient and surface ...were: ...
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Intracellular pH regulation and proton transport by rabbit renal medullary collecting duct cells Role of plasma membrane proton adenosine triphosphatase
... renal medullary collecting duct is thought to occur via a luminal ...across medullary collecting duct (MCD) cells membranes, intracellular pH (pHi) regulation and proton ...
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Hormonal regulation of proton secretion in rabbit medullary collecting duct
... the medullary collecting duct from inner stripe of outer ...rabbit medullary collecting ducts before, during, and after exposure to each test ...
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Anion secretion by the inner medullary collecting duct Evidence for involvement of the cystic fibrosis transmembrane conductance regulator
... transmonolayer short circuit current that was not dependent on the presence of Na+ in the apical solution, but was dependent on the presence of Cl- and HCO3-. This current was not inhibited by the loop diuretic ...
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The role of the V ATPase in renal epithelial H+ transport
... In the cortical and outer medullary collecting tubule, proton secretion by the Atype intercalated cells varies with the proton electrochemical gradient across the apical plasma membrane,[r] ...
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The role of the medullary collecting ducts in postobstructive diuresis
... the medullary collecting duct of such ...the medullary collecting duct is the critical nephron segment affected by ureteral obstruction, since postobstructive ...
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Enhancement of electrogenic Na+ transport across rat inner medullary collecting duct by glucocorticoid and by mineralocorticoid hormones
... We have investigated the effect of steroid hormones on Na+ transport by rat renal inner medullary collecting duct (IMCD) cells. These cells, grown on permeable supports in primary culture, grow to ...
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rENaC is the predominant Na+ channel in the apical membrane of the rat renal inner medullary collecting duct
... inner medullary collecting duct (IMCD), absorbs Na+ by an electrogenic process that involves the entry through an apical (luminal) membrane Na+ ...
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Endothelin inhibits vasopressin stimulated water permeability in rat terminal inner medullary collecting duct
... stimulated water permeability (PF) in rat terminal inner medullary collecting duct (IMCD) perfused in vitro. ET caused a rapid, dose-dependent, and reversible fall in AVP- but not cyclic ...
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Atrial natriuretic peptide(31 67) inhibits Na+ transport in rabbit inner medullary collecting duct cells Role of prostaglandin E2
... Atrial natriuretic peptide (ANP)(31-67), a portion of the atrial peptide prohormone, circulates in humans, and its plasma level varies with atrial pressure. Like the more widely studied carboxy-terminal fragment ...
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Functional characterization of three intercalated cell subtypes in the rabbit outer cortical collecting duct
... observed. 39% of intercalated cells had only apical Cl(-)-HCO3- exchange (beta cell), 4% had only basolateral Cl(-)-HCO3- exchange (alpha cell), and 57% had both apical and basolateral Cl(-)-HCO3- exchange (gamma cell). ...
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Cytokine induced expression of a nitric oxide synthase in rat renal tubule cells
... Nitric oxide (NO.) has been implicated in the regulation of renal vascular tone and tubular sodium transport. While the endothelial cell is a well known source of NO(.), recent studies suggest that tubular epithelial ...
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The bradykinin B<sub>2</sub> receptor induces multiple cellular responses leading to the proliferation of human renal carcinoma cell lines
... 7,8 We have reported previously that BK is a potent mitogenic factor for a kidney cell line derived from the inner medullary collecting duct of mice (mIMCD-3 cells), and demonstrat[r] ...
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