Outer membrane vesicle
Combined Administration of Meningococcal Serogroup B Outer Membrane Vesicle Vaccine and Conjugated Serogroup C Vaccine Indicated for Prevention of Meningococcal Disease Is Safe and Immunogenic
... MenBvac and Menjugate are safe and efficacious vaccines. The purpose of this study was to evaluate safety and immunogenicity of the combination (MenB/C) of the lyophilized active components of the conjugated group C ...
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Persisting Immune Responses Indicating Long-Term Protection after Booster Dose with Meningococcal Group B Outer Membrane Vesicle Vaccine
... B outer membrane vesicle (OMV) vaccine, Men- ...on outer membrane proteins in the form of vesicles and is prepared from a clinical isolate repre- sentative of that epidemic ...
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Cellular Immune Responses in Humans Induced by Two Serogroup B Meningococcal Outer Membrane Vesicle Vaccines Given Separately and in Combination
... MenBvac and MeNZB are safe and efficacious outer membrane vesicle (OMV) vaccines against serogroup B meningococcal dis- ease. Antibody responses have previously been investigated in a clinical trial ...
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Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa
... stimulating outer membrane vesicle (OMV) ...the outer membrane, causing expansion of the outer leaflet and consequently inducing ...the outer membrane before it can ...
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Seroprevalence of Bactericidal and Anti-Outer Membrane Vesicle Antibodies to Neisseria meningitidis Group B in England
... Outer membrane vesicle (OMV) and recombinant protein-based vaccines targeted against multiple strains of group B meningococci are under development. The serum bactericidal antibody (SBA) assay has ...
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Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10
... Production and characterization of MSC-derived NVs NVs were isolated from MSCs according to the procedure described in the “Materials and methods” section. Briefly, early passages of MSCs were gathered and serially ex- ...
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Engineered outer membrane vesicle is potent to elicit HPV16E7-specific cellular immunity in a mouse model of TC-1 graft tumor
... OMVs increased, the fluorescence intensity of the cells and the ratio of positive cells augmented. Similarly, Dio-labeled OMVs exhibited fluorescence in cells, revealing that the OMVs themselves were internalized ...
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A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine
... ABSTRACT MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningo- coccal vaccine for capsular B strains. The vaccine contains detergent-extracted outer membrane vesicles (dOMV) and three ...
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Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization
... the vesicle remained non-ag- gregated during storage for both products, changes in tertiary structure were more pronounced in the liquid omvPV compared to the spray dried omvPV indicating enhanced storage ...
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Sodium taurocholate stimulates Campylobacter jejuni outer membrane vesicle production via down-regulation of the maintenance of lipid asymmetry pathway
... the membrane of an OMV contains either LOS or LPS, it has been suggested OMVs can confer protection against compounds that target or bind to this component of the bacterial membrane, such as bacteriophage ...
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Outer Membrane Vesicle Production Facilitates LPS Remodeling and Outer Membrane Maintenance in Salmonella during Environmental Transitions
... ABSTRACT The ability of Gram-negative bacteria to carefully modulate outer membrane (OM) composition is essential to their survival. However, the asymmetric and heterogeneous structure of the Gram-negative ...
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Effectiveness of a Group B outer Membrane Vesicle Meningococcal Vaccine in Preventing Hospitalization from Gonorrhea in New Zealand: a Retrospective Cohort Study
... meningococcal outer membrane vesicles (OMV) vaccines in Cuba,[8] New Zealand (NZ), 10 and to a limited extent, Norway [9,10], suggested that meningococcal B OMV vaccines may reduce the risk of ...
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High dissolved oxygen tension triggers outer membrane vesicle formation by Neisseria meningitidis
... Our initial results show that OMV size was not affected although oxidative stress can cause damage to bacteria. In general, increased oxygen concentrations could affect bacterial growth and the production of biological ...
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A Bilayer Couple Model of Bacterial Outer Membrane Vesicle Biogenesis
... a membrane stress response in Escherichia coli (24), most Gram-negative bacteria naturally produce OMVs while growing under perceived optimal, stress-free conditions ...the membrane (18, 40); PQS possesses ...
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A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Protection against Lethal Sepsis
... The environmental Gram-negative encapsulated bacillus Burkholderia pseudomallei is the causative agent of melioidosis, a dis- ease associated with high morbidity and mortality rates in areas of Southeast Asia and ...
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Immunogenicity and Safety of a Combination of Two Serogroup B Meningococcal Outer Membrane Vesicle Vaccines
... After the booster dose the proportions of subjects with SBA titers of ⱖ 4 against strain 44/76 ranged from 67% in the group receiving three doses of MeNZB plus one dose of MenBvac to 85%[r] ...
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Immunogenicity, Reactogenicity, and Safety of a P1.7b,4 Strain-Specific Serogroup B Meningococcal Vaccine Given to Preteens
... New Zealand (NZ) has experienced a Neisseria meningitidis serogroup B epidemic since 1991. MeNZB, a strain-specific outer membrane vesicle vaccine made using an NZ epidemic strain isolate, NZ98/254 ...
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Genetic Similarity of Gonococcal Homologs to Meningococcal Outer Membrane Proteins of Serogroup B Vaccine
... IMPORTANCE Gonorrhea, a sexually transmitted disease, causes substantial global morbidity and economic burden. New prevention and control measures for this dis- ease are urgently needed, as strains resistant to almost ...
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Three Doses of an Experimental Detoxified L3-Derived Lipooligosaccharide Meningococcal Vaccine Offer Good Safety but Low Immunogenicity in Healthy Young Adults
... This open, randomized phase I study evaluated the safety and reactogenicity of an experimental meningo- coccal serogroup B (MenB) vaccine obtained from outer membrane vesicle detoxified L3-derived ...
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PubMedCentral-PMC4797321.pdf
... complicating the molecular pathways involved in neuronal membrane trafficking. One key group of interacting proteins is the Sec1/Munc18 (SM) family, which regulates synaptic vesicle exocytosis mediated by ...
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