Outer membrane vesicle vaccine
Combined Administration of Meningococcal Serogroup B Outer Membrane Vesicle Vaccine and Conjugated Serogroup C Vaccine Indicated for Prevention of Meningococcal Disease Is Safe and Immunogenic
... C vaccine Menjugate when reconstituted with the full liquid group B outer membrane vesicle vaccine MenBvac compared to MenBvac and Menjugate given ...no vaccine-related serious ...
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Persisting Immune Responses Indicating Long-Term Protection after Booster Dose with Meningococcal Group B Outer Membrane Vesicle Vaccine
... an outer membrane vesicle vaccine against systemic meningococcal disease caused by serogroup B Neisseria ...the vaccine strain and heterologous strains (non-vaccine-type strains) ...
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A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Protection against Lethal Sepsis
... OMV vaccine to eradicate persistent ...OMV vaccine against septicemic melioidosis is promising and provides further incentive to identify, to incorporate, and to deliver critical protec- tive antigens using ...
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Immunogenicity and Safety of Three Doses of a Bivalent (B:4:P1.19,15 and B:4:P1.7-2,4) Meningococcal Outer Membrane Vesicle Vaccine in Healthy Adolescents
... meningococcal outer membrane vesicle (OMV) vaccine ...wide vaccine coverage particularly of the circulating strains in ...OMV vaccine when given to healthy 12- to 18-year-olds on ...
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A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine
... WT vaccine antigen affected the anti-FHbp antibody repertoire and resulted in lower inhibition of FH binding (9, ...NOMV-FHbp vaccine inhibited the binding of FH to FHbp (mean inhibition, 40%; P ⬍ ...
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Immunogenicity, Reactogenicity, and Safety of a P1.7b,4 Strain-Specific Serogroup B Meningococcal Vaccine Given to Preteens
... strain-specific outer membrane vesicle vaccine made using an NZ epidemic strain isolate, NZ98/254 (B:4: ...parent vaccine strain 44/76; ...no vaccine-related serious adverse ...B ...
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Effectiveness of a Group B outer Membrane Vesicle Meningococcal Vaccine in Preventing Hospitalization from Gonorrhea in New Zealand: a Retrospective Cohort Study
... ratios. Vaccine effectiveness estimates were calculated as 1-Hazard Ratio expressed as ...deprivation, vaccine effectiveness (MeNZB™) against hospitalization caused by gonorrhea was estimated to be 24% (95% ...
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Cellular Immune Responses in Humans Induced by Two Serogroup B Meningococcal Outer Membrane Vesicle Vaccines Given Separately and in Combination
... OMV vaccine, consisting of MenBvac and MeNZB (half dose each) ad- sorbed to aluminum hydroxide, were then tested in a clinical trial design consisting of three primary doses given with 6-week inter- vals and a ...
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High dissolved oxygen tension triggers outer membrane vesicle formation by Neisseria meningitidis
... the outer membrane of the bacteria, are non-replicating, and characteristically are full of pathogen associated molecular ...for vaccine design and have been successfully used as such [6, ...rial ...
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Immunogenicity and Safety of a Combination of Two Serogroup B Meningococcal Outer Membrane Vesicle Vaccines
... combined vaccine was immunogenic with regard to both vaccine strains and that the responses were of the same magnitude as the homologous responses observed for each individual vaccine, even though ...
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Proteomic Analysis and Immunogenicity of Mannheimia haemolytica Vesicles
... engineered outer membrane vesicle ...2002. Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen pre- senting cells-impact on ...
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Seroprevalence of Bactericidal and Anti-Outer Membrane Vesicle Antibodies to Neisseria meningitidis Group B in England
... The group B capsule is known to be poorly immunogenic, and previous studies have shown that SBA to group B menin- gococci is primarily directed at noncapsular antigens (8). In MenZB vaccine trials, SBA ...
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Engineered outer membrane vesicle is potent to elicit HPV16E7-specific cellular immunity in a mouse model of TC-1 graft tumor
... the vaccine, we clearly demonstrated that an OMV- based vaccine efficiently induced both specific humoral and cellular immune responses in the current ...a vaccine platform, it will still be of value ...
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In Silico Design and Evaluation of Acinetobacter baumannii Outer Membrane Protein A (OmpA) Antigenic Peptides As Vaccine Candidate in Immunized Mice
... potential vaccine candidate that may prevent these infections is A. baumannii outer membrane protein A ...apoptosis, outer membrane vesicle biogenesis, and serum ...
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Bacterial outer membrane vesicles and vaccine applications
... Summary: Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano- sized structures exhibit remarkable potential for ...
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Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization
... pertussis vaccine formulation, based on OMVs, with increased ther- mostability compared to the liquid ...liquid vaccine when administered via the same ...
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Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa
... gene transfer mediating antibiotic resistance (4, 18), and trafficking of small-molecule communication signals (16). Because of their ability to package and transport such varied cargo, OMVs have been described as a ...
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Three Doses of an Experimental Detoxified L3-Derived Lipooligosaccharide Meningococcal Vaccine Offer Good Safety but Low Immunogenicity in Healthy Young Adults
... (MenB) vaccine obtained from outer membrane vesicle detoxified L3-derived lipooligosac- ...experimental vaccine (provided in five formulations, n ⴝ 25 in each group) or VA-Mengoc-BC ...
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Genetic Similarity of Gonococcal Homologs to Meningococcal Outer Membrane Proteins of Serogroup B Vaccine
... of outer membrane vesicle (OMV) meningococcal serogroup B vaccine (MeNZB) against ...MenB vaccine, MenB-4C, consists of a recombinant FHbp, NhbA, NadA, and the MeNZB ...pressed ...
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Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based
... replicative property and adjuvant effect [105], but they con- tain substantial immunogenic components [1] associated with parent bacteria, which may elicit potent innate and adaptive immune responses against bacterial ...
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